Výsledky vyhledávání - "Met, methionine"

Analysis of 2-methylcitric acid, methylmalonic acid, and total homocysteine in dried blood spots by LC-MS/MS for application in the newborn screening laboratory: A dual derivatization approach

Autor: Bojana Rakic, Hilary Vallance, Joshua A. Dubland, Graham Sinclair

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 20, Iss, Pp 1-10 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab

Highlights • Analysis of 2-methylcitric acid, methylmalonic acid, and homocysteine in DBS. • A dual derivatization LC-MS/MS strategy developed for use in second-tier NBS. • Second-tier panel replaces multiple initial follow-up tests. • Improv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50beebd48c7a916d499a13356b9284c0
https://doi.org/10.1016/j.jmsacl.2021.03.001

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In silico study reveals binding potential of rotenone at multiple sites of pulmonary surfactant proteins: A matter of concern

Autor: Prem Rajak, Sumedha Roy, Achintya Kumar Pal, Manas Paramanik, Moumita Dutta, Sayanti Podder, Saurabh Sarkar, Abhratanu Ganguly, Moutushi Mandi, Anik Dutta, Kanchana Das, Siddhartha Ghanty, Salma Khatun

Publikováno v: Current Research in Toxicology, Vol 2, Iss, Pp 411-423 (2021)
Current Research in Toxicology
CURRENT RESEARCH IN TOXICOLOGY

Graphical abstract
Highlights • Inhalation of rotenone exposes lung surfactant proteins (SP) to this pesticide. • SP-A and SP-D provides protection from microbial infection. • SP-B and SP-C maintain structure and respiratory function of lu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f2cd79baf46b999beeed39c977274d
http://www.sciencedirect.com/science/article/pii/S2666027X21000414

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Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed CellsSummary

Autor: Nicolai Lehnert, Dhiman Maitra, Stephen W. Ragsdale, Laure Rittié, M. Bishr Omary, Alexey I. Nesvizhskii, Haoming Zhang, Matthew W. Wolf, Harald Herrmann, Venkatesha Basrur, Rani Richardson, Yoichi Osawa, Eric L. Carter

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 4, Pp 659-682.e1 (2019)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Porphyrias are caused by porphyrin accumulation resulting from defects in the heme biosynthetic pathway that typically lead to photosensitivity and possible end-stage liver disease with an increased risk of hepatocellular carcinoma.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0592cf3cff3ae349fa52696e431bb166
http://www.sciencedirect.com/science/article/pii/S2352345X19300724

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Phytoconstituents from ten natural herbs as potent inhibitors of main protease enzyme of SARS-COV-2: in silico study

Autor: Kavita Bhagat, Preet Mohinder Singh Bedi, Atamjit Singh, Amit Duggal, Puja Gulati, Komalpreet Kaur, Shilpa Dudhal, Harmandeep Kaur Gulati, Jatinder Vir Singh, Jaspreet Kaur, Harbinder Singh, Nitish Kumar

Publikováno v: Phytomedicine Plus
Phytomedicine Plus, Vol 1, Iss 4, Pp 100083-(2021)

Background Lack of treatment of novel Coronavirus disease led to the search of specific antivirals that are capable to inhibit the replication of the virus. The plant kingdom has demonstrated to be an important source of new molecules with antiviral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939ef681815567886f1f3e386c85714b
http://europepmc.org/articles/PMC8180089

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Endocytosis of nutrient transporters in fungi: the ART of connecting signaling and trafficking

Autor: Gabriel Talaia, Margarida Casal, Hernâni Gerós, Sandra Paiva, Rosana Maria Abreu Alves, Cláudia Barata-Antunes, Robert Mans

Publikováno v: Computational and Structural Biotechnology Journal, 19
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1713-1737 (2021)

Plasma membrane transporters play pivotal roles in the import of nutrients, including sugars, amino acids, nucleobases, carboxylic acids, and metal ions, that surround fungal cells. The selective removal of these transporters by endocytosis is one of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632ee65f13d8bd8b6a66921459f5d65f
https://hdl.handle.net/1822/72047

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Lipid remodeling in response to methionine stress in MDA-MBA-468 triple-negative breast cancer cells

Autor: Jue Hou, Oliver Fiehn, Peter K. Kaiser, Dawei Lin, Bruce J. Tromberg, Stacey L. Borrego, Johannes F. Fahrmann

Publikováno v: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100056-(2021)

Methionine (Met) is an essential amino acid and critical precursor to the cellular methyl donor S-adenosylmethionine. Unlike nontransformed cells, cancer cells have a unique metabolic requirement for Met and are unable to proliferate in growth media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5edbc2530f51189a9d514fa0802207d
https://pubmed.ncbi.nlm.nih.gov/33647277

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Redox regulation by reversible protein S-thiolation in Gram-positive bacteria

Autor: Marcel Imber, Agnieszka J. Pietrzyk-Brzezinska, Haike Antelmann

Publikováno v: Redox Biology
Redox Biology, Vol 20, Iss, Pp 130-145 (2019)

Low molecular weight (LMW) thiols play an important role as thiol-cofactors for many enzymes and are crucial to maintain the reduced state of the cytoplasm. Most Gram-negative bacteria utilize glutathione (GSH) as major LMW thiol. However, in Gram-po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f489c6dc700b786fd74ac141fe7a87
http://europepmc.org/articles/PMC6178380

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High incidence of low vitamin B12 levels in Estonian newborns

Autor: Katrin Õunap, Mari-Anne Vals, Kai Muru, Kadi Künnapas, Karit Reinson, Annika Kriisa

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 15, Iss, Pp 1-5 (2018)
Molecular Genetics and Metabolism Reports

Vitamin B12 deficiency seems to be more common worldwide than previously thought. However, only a few reports based on data from newborn screening (NBS) programs have drawn attention to that subject. In Estonia, over the past three years, we have dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a47e8269b32637787776ad61d82292
http://www.sciencedirect.com/science/article/pii/S2214426917301301

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S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice

Autor: Andrew J. Andrews, Yin-Ming Kuo, Warren D. Kruger, Sapna Gupta, Hyung-Ok Lee, Liqun Wang

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 15, Iss, Pp 15-21 (2018)
Molecular Genetics and Metabolism Reports

Elevated plasma total homocysteine (tHcy) is associated with a number of human diseases including coronary artery disease, stroke, osteoporosis and dementia. It is highly correlated with intracellular S-adenosylhomocysteine (SAH). Since SAH is a stro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4f365c5a4c126ef1a98a5aa1560367
http://www.sciencedirect.com/science/article/pii/S2214426918300028

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10-Gingerol as an inducer of apoptosis through HTR1A in cumulus cells: In-vitro and in-silico studies

Autor: Sutiman Bambang Sumitro, Mohammad Aris Widodo, Kiptiyah Kiptiyah, Aulanni'am Aulanni'am, Gatot Ciptadi, Widodo Widodo

Publikováno v: Journal of Taibah University Medical Sciences, Vol 12, Iss 5, Pp 397-406 (2017)
Journal of Taibah University Medical Sciences

Cumulus cells play a crucial role as essential mediators in the maturation of ova. Ginger contains 10-gingerol, which induces apoptosis in colon cancer cells. Based on this hypothesis, this study aimed to determine whether 10-gingerol is able to indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73471c1ea3864afe337bbdf878d1c0a8
http://www.sciencedirect.com/science/article/pii/S165836121730094X

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