Trojan Horse Treatment Based on Peg-Coated Extracellular Vesicles to Deliver Doxorubicin to Melanoma in Vitro and in Vivo

Autor: Lucian Barbu-Tudoran, Laura Patras, Emilia Licarete, Chiroi P, Alina Porfire, Monica Potara, Paul-Adrian Bulzu, Tranca Ra, Lavinia Luput, Valentin Florian Rauca, Negrea G, Alina Sesarman, Hajdu R, Manuela Banciu, Szedlacsek Ss, Munteanu Cva, Artur Ionescu, Meszaros Ms, Kosa Ac

Tailoring extracellular vesicles (EVs) as targeted drug delivery systems to enhance the therapeutic efficacy showed superior advantage over liposomal therapies. Herein, we developed a novel nanotool for targeting B16.F10 murine melanoma, based on EVs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c26a91f69663f9ca47304737d6e623
https://doi.org/10.20944/preprints202105.0229.v1

Trojan horse treatment based on PEG-coated extracellular vesicles to deliver doxorubicin to melanoma in vitro and in vivo .

Autor: Patras L; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Ionescu AE; Department of Enzymology, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania., Munteanu C; Department of Bioinformatics and Structural Biochemistry, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania., Hajdu R; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Kosa A; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Porfire A; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania., Licarete E; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania.; Molecular Biology Centre, Interdisciplinary Research Institute in Bio-Nano-Sciences, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Rauca VF; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Sesarman A; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Luput L; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Bulzu P; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Chiroi P; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Tranca RA; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Meszaros MS; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Negrea G; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Barbu-Tudoran L; 'C.Craciun' Electron Microscopy Center, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Potara M; Nanobiophotonics Center, Interdisciplinary Research Institute in Bio-Nano-Sciences and Faculty of Physics, 'Babes-Bolyai' University, Cluj-Napoca, Romania., Szedlacsek S; Department of Enzymology, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania., Banciu M; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, 'Babes-Bolyai' University, Cluj-Napoca, Romania.

Publikováno v: Cancer biology & therapy [Cancer Biol Ther] 2022 Dec 31; Vol. 23 (1), pp. 1-16. Date of Electronic Publication: 2021 Dec 29.