MDS and AML show elevated fractions of CD34-positive blast cell populations with a high anti-apoptotic versus proliferation ratio.

Autor: Mestrum SGC; Department of Genetics & Cell Biology, GROW-Research Institute for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Clinical Chemistry & Hematology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands., Roanalis BYV; Department of Clinical Chemistry & Hematology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands., de Wit NCJ; Central Diagnostic Laboratory (CDL), Maastricht University Medical Center, Maastricht, the Netherlands., Drent RJM; Department of Clinical Chemistry & Hematology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands., Boonen BT; Department of Orthopedic Surgery, Zuyderland Medical Center, Heerlen, the Netherlands., van Hemert WLW; Department of Orthopedic Surgery, Zuyderland Medical Center, Heerlen, the Netherlands., Hopman AHN; Department of Genetics & Cell Biology, GROW-Research Institute for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, the Netherlands., Ramaekers FCS; Department of Genetics & Cell Biology, GROW-Research Institute for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, the Netherlands; Nordic-MUbio, an Absolute Biotech Company, Susteren, the Netherlands., Leers MPG; Department of Clinical Chemistry & Hematology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands; Department of Environmental Sciences, Faculty of Science, Open Universiteit, Heerlen, the Netherlands. Electronic address: mat.leers@zuyderland.nl.

Publikováno v: Leukemia research [Leuk Res] 2024 Jul; Vol. 142, pp. 107520. Date of Electronic Publication: 2024 May 15.

The Proliferation Index of Erythroid Cells Predicts the Development of Transfusion-dependence in Myelodysplastic Syndrome Patients With Mildly Reduced Hemoglobin Levels at Initial Diagnosis.

Autor: Mestrum SGC; Department of Molecular Cell Biology, GROW-School for Oncology and Reproduction, Maastricht University Medical Center, The Netherlands.; Department of Clinical Chemistry & Hematology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands., de Wit NCJ; Central Diagnostic Laboratory (CDL), Maastricht University Medical Center, The Netherlands., Cremers EMP; Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands., Drent RJM; Department of Clinical Chemistry & Hematology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands., Ramaekers FCS; Department of Molecular Cell Biology, GROW-School for Oncology and Reproduction, Maastricht University Medical Center, The Netherlands.; Nordic-MUbio, Susteren, The Netherlands., Hopman AHN; Department of Molecular Cell Biology, GROW-School for Oncology and Reproduction, Maastricht University Medical Center, The Netherlands., Leers MPG; Department of Clinical Chemistry & Hematology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands.

Publikováno v: HemaSphere [Hemasphere] 2022 Nov 09; Vol. 6 (12), pp. e804. Date of Electronic Publication: 2022 Nov 09 (Print Publication: 2022).

Proliferative and anti-apoptotic fractions in maturing hematopoietic cell lineages and their role in homeostasis of normal bone marrow.

Autor: Mestrum SGC; Department of Molecular Cell Biology, GROW-School for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, The Netherlands.; Department of Clinical Chemistry and Hematology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands., Vanblarcum RBY; Department of Clinical Chemistry and Hematology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands., Drent RJM; Department of Clinical Chemistry and Hematology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands., Boonen BT; Department of Orthopedic Surgery, Zuyderland Medical Center, Heerlen, The Netherlands., van Hemert WLW; Department of Orthopedic Surgery, Zuyderland Medical Center, Heerlen, The Netherlands., Ramaekers FCS; Department of Molecular Cell Biology, GROW-School for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, The Netherlands.; Nordic-MUbio, Susteren, The Netherlands., Hopman AHN; Department of Molecular Cell Biology, GROW-School for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, The Netherlands., Leers MPG; Department of Clinical Chemistry and Hematology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands.

Publikováno v: Cytometry. Part A : the journal of the International Society for Analytical Cytology [Cytometry A] 2022 Jul; Vol. 101 (7), pp. 552-563. Date of Electronic Publication: 2022 Apr 27.

Integration of the Ki-67 proliferation index into the Ogata score improves its diagnostic sensitivity for low-grade myelodysplastic syndromes.

Autor: Mestrum SGC; Department of Molecular Cell Biology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Clinical Chemistry & Hematology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands. Electronic address: sgc.mestrum@maastrichtuniversity.nl., Cremers EMP; Department of Internal Medicine, Division of Hematology, Maastricht University Medical Center, Maastricht, the Netherlands., de Wit NCJ; Central Diagnostic Laboratory (CDL), Maastricht University Medical Center, Maastricht, the Netherlands., Drent RJM; Department of Clinical Chemistry & Hematology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands., Ramaekers FCS; Department of Molecular Cell Biology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands; Nordic-MUbio, Susteren, the Netherlands., Hopman AHN; Department of Molecular Cell Biology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands., Leers MPG; Department of Clinical Chemistry & Hematology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands.

Publikováno v: Leukemia research [Leuk Res] 2022 Feb; Vol. 113, pp. 106789. Date of Electronic Publication: 2022 Jan 11.

The potential of proliferative and apoptotic parameters in clinical flow cytometry of myeloid malignancies.

Autor: Mestrum SGC; Department of Clinical Chemistry and Hematology, Zuyderland Medical Centre, Sittard-Geleen, The Netherlands.; Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands; and., Hopman AHN; Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands; and., Ramaekers FCS; Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands; and.; Nordic-MUbio, Susteren, The Netherlands., Leers MPG; Department of Clinical Chemistry and Hematology, Zuyderland Medical Centre, Sittard-Geleen, The Netherlands.

Publikováno v: Blood advances [Blood Adv] 2021 Apr 13; Vol. 5 (7), pp. 2040-2052.