Amyloid PET detects the deposition of brain Aβ earlier than CSF fluid biomarkers.

Autor: Lowe VJ; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Mester CT; Departments of Radiology and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA., Lundt ES; Departments of Radiology and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA., Lee J; Department of Biomedical Engineering, College of Medicine, Hanyang University, Seoul, Republic of Korea., Ghatamaneni S; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Algeciras-Schimnich A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Campbell MR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Nguyen A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Min HK; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Senjem ML; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.; Department of Information Technology, Mayo Clinic, Rochester, Minnesota, USA., Machulda MM; Department of Psychology, Mayo Clinic, Rochester, Minnesota, USA., Schwarz CG; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Kandimalla KK; Department of Pharmaceutics and Brain Barriers Research Center, University of Minnesota, Minneapolis, Minnesota, USA., Kantarci K; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Boeve B; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Vemuri P; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Jones DT; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Knopman D; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Mielke MM; Department of Epidemiology and Prevention at Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Nov; Vol. 20 (11), pp. 8097-8112. Date of Electronic Publication: 2024 Oct 11.

Evidence against a temporal association between cerebrovascular disease and Alzheimer's disease imaging biomarkers.

Autor: Cogswell PM; Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. Cogswell.petrice@mayo.edu., Lundt ES; Department of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Therneau TM; Department of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Mester CT; Department of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Wiste HJ; Department of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Graff-Radford J; Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Schwarz CG; Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Senjem ML; Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.; Department of Information Technology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Gunter JL; Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Reid RI; Department of Information Technology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Przybelski SA; Department of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Knopman DS; Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Vemuri P; Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Petersen RC; Department of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.; Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Jack CR Jr; Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Publikováno v: Nature communications [Nat Commun] 2023 May 29; Vol. 14 (1), pp. 3097. Date of Electronic Publication: 2023 May 29.

Age of onset moderates the effects of Vascular Risk Factors on Neurodegeneration, Blood-Brain-Barrier permeability, and cognitive decline in Alzheimer's Disease.

Autor: Bonomi, Chiara Giuseppina¹ (AUTHOR), Motta, Caterina¹ (AUTHOR), Di Donna, Martina Gaia¹ (AUTHOR), Poli, Martina¹ (AUTHOR), Nuccetelli, Marzia² (AUTHOR), Bernardini, Sergio² (AUTHOR), Mercuri, Nicola Biagio³ (AUTHOR), Koch, Giacomo^4,5 (AUTHOR), Martorana, Alessandro¹ (AUTHOR) martorana@med.uniroma2.it

Publikováno v: Alzheimer's Research & Therapy. 11/16/2024, Vol. 16 Issue 1, p1-11. 11p.

Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms.

Autor: Khan, Ahmed Faraz, Iturria-Medina, Yasser

Publikováno v: Translational Psychiatry; 9/23/2024, Vol. 14 Issue 1, p1-27, 27p

White matter changes in empirically derived incident MCI subtypes in the Mayo Clinic Study of Aging.

Autor: Machulda, Mary M., Lundt, Emily S., Mester, Carly T., Albertson, Sabrina M., Raghavan, Sheelakumari, Reid, Robert I., Schwarz, Christopher G., Graff‐Radford, Jonathan, Jack, Clifford R., Knopman, David S., Mielke, Michelle M., Kremers, Walter K., Petersen, Ronald C., Bondi, Mark W., Vemuri, Prashanthi

Publikováno v: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring; 2021, Vol. 13 Issue 1, p1-11, 11p