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pro vyhledávání: '"Messer Philipp W"'
Akademický článek
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Publikováno v:
BMC Evolutionary Biology, Vol 7, Iss 1, p 191 (2007)
Abstract Background Insertions and deletions of DNA segments (indels) are together with substitutions the major mutational processes that generate genetic variation. Here we focus on recent DNA insertions and deletions in protein coding regions of th
Externí odkaz:
https://doaj.org/article/a6f0f6dad0504b6380ccd09ad4b2822e
Akademický článek
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Autor:
Champer, Jackson, Yang, Emily, Lee, Esther, Liu, Jingxian, Clark, Andrew G., Messer, Philipp W.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2020 Sep . 117(39), 24377-24383.
Externí odkaz:
https://www.jstor.org/stable/26969546
The role of positive selection in human evolution remains controversial. On the one hand, scans for positive selection have identified hundreds of candidate loci and the genome-wide patterns of polymorphism show signatures consistent with frequent po
Externí odkaz:
http://arxiv.org/abs/1308.4951
Rapid adaptation has been observed in numerous organisms in response to selective pressures, such as the application of pesticides and the presence of pathogens. When rapid adaptation is driven by rare alleles from the standing genetic variation or b
Externí odkaz:
http://arxiv.org/abs/1303.0906
Synonymous sites are generally assumed to be subject to weak selective constraint. For this reason, they are often neglected as a possible source of important functional variation. We use site frequency spectra from deep population sequencing data to
Externí odkaz:
http://arxiv.org/abs/1301.3325
Autor:
Messer, Philipp W.
SLiM is an efficient forward population genetic simulation designed for studying the effects of linkage and selection on a chromosome-wide scale. The program can incorporate complex scenarios of demography and population substructure, various models
Externí odkaz:
http://arxiv.org/abs/1301.3109
Autor:
Messer, Philipp W., Petrov, Dmitri A.
Population genomic studies have shown that genetic draft and background selection can profoundly affect the genome-wide patterns of molecular variation. We performed forward simulations under realistic gene-structure and selection scenarios to invest
Externí odkaz:
http://arxiv.org/abs/1211.0060
Autor:
Messer, Philipp W., Neher, Richard A.
Publikováno v:
Genetics 191:593-605, 2012
Selective sweeps are typically associated with a local reduction of genetic diversity around the adaptive site. However, selective sweeps can also quickly carry neutral mutations to observable population frequencies if they arise early in a sweep and
Externí odkaz:
http://arxiv.org/abs/1206.6768