Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF): a randomised, open-label, phase 2 trial.

Autor: Schreuder FHBM; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands., van Nieuwenhuizen KM; Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands., Hofmeijer J; Department of Neurology, Rijnstate Hospital, Arnhem, Netherlands., Vermeer SE; Department of Neurology, Rijnstate Hospital, Arnhem, Netherlands., Kerkhoff H; Department of Neurology, Albert Schweitzer Hospital, Dordrecht, Netherlands., Zock E; Department of Neurology, Albert Schweitzer Hospital, Dordrecht, Netherlands., Luijckx GJ; Department of Neurology, University Medical Centre Groningen, Groningen, Netherlands., Messchendorp GP; Department of Neurology, University Medical Centre Groningen, Groningen, Netherlands., van Tuijl J; Department of Neurology, Elisabeth-TweeSteden Hospital, Tilburg, Netherlands., Bienfait HP; Department of Neurology, Gelre Hospital, Apeldoorn, Netherlands., Booij SJ; Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, Netherlands., van den Wijngaard IR; Department of Neurology, Haaglanden MC, The Hague, Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, Netherlands., Remmers MJM; Department of Neurology, Amphia, Breda, Netherlands., Schreuder AHCML; Department of Neurology, Zuyderland, Heerlen, Netherlands., Dippel DW; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, Netherlands., Staals J; Department of Neurology, Maastricht University Medical Center, Maastricht, Netherlands., Brouwers PJAM; Department of Neurology, Medisch Spectrum Twente, Enschede, Netherlands., Wermer MJH; Department of Neurology, Leiden University Medical Center, Leiden, Netherlands., Coutinho JM; Department of Neurology, Amsterdam UMC location AMC, Amsterdam, Netherlands., Kwa VIH; Department of Neurology, OLVG, Amsterdam, Netherlands., van Gelder IC; Department of Cardiology, University Medical Centre Groningen, Groningen, Netherlands., Schutgens REG; Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands., Zweedijk B; Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands., Algra A; Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands., van Dalen JW; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands., Jaap Kappelle L; Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands., Rinkel GJE; Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands., van der Worp HB; Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands., Klijn CJM; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands; Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands. Electronic address: karin.klijn@radboudumc.nl.

Publikováno v: The Lancet. Neurology [Lancet Neurol] 2021 Nov; Vol. 20 (11), pp. 907-916.