Výsledky vyhledávání - "Meryem El Ouardi"

Akademický článek

Modulation of the photobehavior of gefitinib and its phenolic metabolites by human transport proteins

Autor: Lorena Tamarit, Meryem El Ouardi, Emilio Lence, Inmaculada Andreu, Concepcion González-Bello, Miguel A. Miranda, Ignacio Vayá

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

The photobiological damage that certain drugs or their metabolites can photosensitize in proteins is generally associated with the nature of the excited species that are generated upon interaction with UVA light. In this regard, the photoinduced dama

Externí odkaz: https://doaj.org/article/84a0dc2636fb4df292a7f01ef5a62ebe

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Akademický článek

Cellular photo(geno)toxicity of gefitinib after biotransformation

Autor: Meryem El Ouardi, Lorena Tamarit, Ignacio Vayá, Miguel A. Miranda, Inmaculada Andreu

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Gefitinib (GFT) is a selective epidermal growth factor receptor (EGFR) inhibitor clinically used for the treatment of patients with non-small cell lung cancer. Bioactivation by mainly Phase I hepatic metabolism leads to chemically reactive metabolite

Externí odkaz: https://doaj.org/article/580e40fbc2804228b98e253c437b9f23

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Switching from ultrafast electron transfer to proton transfer in excited drug-protein complexes upon biotransformation

Autor: Lorena Tamarit, Meryem El Ouardi, Emilio Lence, Inmaculada Andreu, Concepción González-Bello, Ignacio Vayá, Miguel A. Miranda

Publikováno v: CHEMICAL SCIENCE
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Photosensitization by drugs is directly related with the excited species and the photoinduced processes arising from interaction with UVA light. In this context, the ability of gefitinib (GFT), a tyrosine kinase inhibitor (TKI) used for the treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1fa12da151fe672c24ca40d77d61b4
http://hdl.handle.net/10261/303992

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Singlet Oxygen and Radical-Mediated Mechanisms in the Oxidative Cellular Damage Photosensitized by the Protease Inhibitor Simeprevir

Autor: Guillermo Garcia-Lainez, Meryem El Ouardi, Alejandro Moreno, Emilio Lence, Concepción González-Bello, Miguel A. Miranda, Inmaculada Andreu

Hepatitis C, a liver inflammation caused by the hepatitis C virus (HCV), is treated with antiviral drugs. In this context, simeprevir (SIM) is an NS3/4A protease inhibitor used in HCV genotypes 1 and 4. It is orally administered and achieves high vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c2d45aed80e904bf6a3e6d51d6b9b1
https://doi.org/10.2139/ssrn.4185908

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Photoprocesses of the tyrosine kinase inhibitor gefitinib: from femtoseconds to microseconds and from solution to the cell

Autor: Ignacio Vayá, Lorena Tamarit, Meryem El Ouardi, Inmaculada Andreu, Miguel A. Miranda

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Chemical Science
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia

[EN] Gefitinib (GFT) is a tyrosine kinase inhibitor currently used for the treatment of metastatic non-small cell lung cancer. Although it has been suggested that GFT can be phototoxic, there are no systematic studies on this issue. Here, the photose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29423017a8bae1770cb66babdb56ec19
https://doi.org/10.1039/d1sc03154f

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