Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Mervyn Thompson"'
Autor:
David Thornhill, Charles McCartan, Ian George Mervyn Thompson, Stephen Spence, Jonathan Talbot-Weiss
Publikováno v:
SAE International Journal of Engines. 4:1354-1364
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc9c0322d9d63f1193246e433be15a2e
https://doi.org/10.4271/2011-01-1144
https://doi.org/10.4271/2011-01-1144
Autor:
Alison I. Muir, Izzy Boyfield, Kalindi Vaidya, Barry Sidney Orlek, Etienne Fleury, David G. Evans, Jackie S. Scott, Hindy Mok, Victoria J. Bolton, Ward John Gerard, Geoffrey Stemp, Tom D. Heightman, Kim L. Matthews, Kirk Lawless, Gareth J. Sanger, Fiona McKay, Alexander J. Stevens, Emma M. Jarvie, James Matthew Bailey, Susan Marie Westaway, Mervyn Thompson, Jonathan B. Basilla
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6452-6458
Optimisation of a series of benzazepine sulfonamide hit compounds identified from high throughput screening led to the discovery of a new series of tractable, potent motilin receptor agonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f11cdd038a55294786dd33de3ee625
https://doi.org/10.1016/j.bmcl.2009.09.027
https://doi.org/10.1016/j.bmcl.2009.09.027
Autor:
Kim Winborn, Sarah C. Lappin, James S. Wright, Vicky Holland, Martin J. Gunthorpe, Harshad Kantilal Rami, Andrew D. Randall, Sandra Arpino, Graham D Smith, Julie Egerton, Stephen J. Brough, Mervyn Thompson, Jeffrey C. Jerman, Sara Luis Hannan, Darren Smart, John B. Davis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:1183-1192
Vanilloid receptor-1 (TRPV1) is a nonselective cation channel, predominantly expressed by sensory neurons, which plays a key role in the detection of noxious painful stimuli such as capsaicin, acid, and heat. TRPV1 antagonists may represent novel the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519bdcb9b1541b2a29cae2ecf14a8d24
https://doi.org/10.1124/jpet.106.116657
https://doi.org/10.1124/jpet.106.116657
Autor:
Jeffrey C. Jerman, Darren Smart, Andrew D. Randall, Becky Sargent, Steve Fell, Geoffrey Stemp, Harshad Kantilal Rami, Alexander J. Stevens, Dominic Sanderson, Martin J. Gunthorpe, John B. Davis, Mervyn Thompson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3287-3291
Small molecule antagonists of the vanilloid receptor TRPV1 (also known as VR1) are disclosed. Pyrrolidinyl ureas such as 8 and 15 (SB-705498) emerged as lead compounds following optimisation of the previously described urea SB-452533. Pharmacological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527e26b9f96416b854135b87b38bfc6e
https://doi.org/10.1016/j.bmcl.2006.03.030
https://doi.org/10.1016/j.bmcl.2006.03.030
Autor:
Jenifer Powles, Neil Upton, Kim Winborn, Nigel Deeks, Christopher N. Johnson, Tania Buck, Mahmood Ahmed, Brenda K. Trail, Darren Jason Mitchell, Mervyn Thompson, Vicky Holland, Laurie J. Gordon, Michael A. Briggs, Jon T. Seal, Stephen Moss, Ashley Garner, David R. Witty, Steven Mark Bromidge, Lorraine Campbell, Andrew D. Medhurst, Tania O. Stean, Geoffrey Stemp, Dieter Hamprecht
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4867-4871
Starting from the potent and selective but poorly brain penetrant 5-HT6 receptor antagonist SB-271046, a successful strategy for improving brain penetration was adopted involving conformational constraint with concomitant reduction in hydrogen bond c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235a4ea32a843eeea24f410f2584c393
https://doi.org/10.1016/j.bmcl.2005.06.107
https://doi.org/10.1016/j.bmcl.2005.06.107
Autor:
Mark S. Duxon, Peter J. Atkinson, Tracey E. Shaw, David R. Thomas, Kevin M. Thewlis, Michael S. Hadley, Beverley Hammond, Geoffrey Stemp, Gary W. Price, Claire M. Scott, Vong Antonio Kuok Keong, Jeannette M. Watson, Steven Mark Bromidge, Christopher N. Johnson, Graham J. Riley, Derek N. Middlemiss, Harshad Kantilal Rami, Stephanie E. North, Laramie Mary Gaster, Kathryn R. Starr, Mervyn Thompson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:737-741
Starting from a high throughput screening hit, a series of 3,4-dihydro-2H-benzoxazinones has been identified with both high affinity for the 5-HT(1A) receptor and potent 5-HT reuptake inhibitory activity. The 5-(2-methyl)quinolinyloxy derivative comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0251a65c1ec7fac2128405b3379b6c
https://doi.org/10.1016/j.bmcl.2004.11.030
https://doi.org/10.1016/j.bmcl.2004.11.030
Autor:
Michael J. Welsh, Mervyn Thompson, Antony Chadderton, Jennifer L. Leonard, Harshad Kantilal Rami, Qin J. Zhang, Laramie Mary Gaster, Karen A. Augustine-Rauch, Patrick J. Wier
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 70:789-807
BACKGROUND SB-236057 is a potent skeletal teratogen in rodents and rabbits, producing axial and posterior somite malformations in cultured rat embryos. The compound shares some structural similarity to cyclopamine. METHODS M13 phage display was used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc7317f911a57c23eccedce4d3f6938
https://doi.org/10.1002/bdra.20076
https://doi.org/10.1002/bdra.20076
Autor:
S. Nasir, Angela Worby, Catherine H. Gill, Harshad Kantilal Rami, Wyman Paul Adrian, Jeffrey C. Jerman, Andrew D. Randall, John B. Davis, Mervyn Thompson, Darren Smart, Julie Egerton, Ellen M. Soffin, Davina E. Owen, Graham D Smith, Ceri H. Davies, Sarah C. Lappin, Martin J. Gunthorpe, L. Howett, S. Luis Hannan
Publikováno v:
Neuropharmacology. 46:133-149
Vanilloid receptor-1 (TRPV1) is a non-selective cation channel, predominantly expressed by peripheral sensory neurones, which is known to play a key role in the detection of noxious painful stimuli, such as capsaicin, acid and heat. To date, a number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd1e6a3014674523ef11c19bfa10804
https://doi.org/10.1016/s0028-3908(03)00305-8
https://doi.org/10.1016/s0028-3908(03)00305-8
Autor:
Joseph P. Adams, Paul R. Raithby, Catherine J. Smith, Stephen D. Roughley, Ian Thomson Forbes, Andrew B. Holmes, Martin E. Fox, Mervyn Thompson, Geoffrey M. Williams, John E. Davies, Edwin C. Davison, Neil John Press
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1494-1514
An intramolecular hydroxylamine-alkyne cyclisation is used for the enantioselective synthesis of the cyclic nitrones 36 and 44. We have demonstrated the use of a novel nitrone protection strategy by cycloaddition of styrene to the cyclic nitrone 44 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c14119467a435e87d557703647127d5
https://doi.org/10.1039/b200328g
https://doi.org/10.1039/b200328g
Publikováno v:
Synthetic Communications. 32:2555-2563
A simple procedure for the preparation of 1,7-disubstituted-1,2,3,4-tetrahydroisoquinolines from 3,4-dihydroisoquinoline (2) is presented. This strategy overcomes the limitation of cyclisation appr...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22d5352ff6d33b869492e13ade3d76e4
https://doi.org/10.1081/scc-120005939
https://doi.org/10.1081/scc-120005939