Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Mervin LH"'
Autor:
Loeffler HH; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden. hannes.loffler@astrazeneca.com., He J; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Tibo A; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Janet JP; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Voronov A; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Mervin LH; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Engkvist O; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
Publikováno v:
Journal of cheminformatics [J Cheminform] 2024 Feb 21; Vol. 16 (1), pp. 20. Date of Electronic Publication: 2024 Feb 21.
Autor:
Cimini BA; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chandrasekaran SN; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kost-Alimova M; Center for Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Miller L; Center for Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Goodale A; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fritchman B; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Byrne P; Center for Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Garg S; Merck Healthcare KGaA, Darmstadt, Germany., Jamali N; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Logan DJ; Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA., Concannon JB; Chemical Biology & Therapeutics Department, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Lardeau CH; Janssen Pharmaceutica N.V., Beerse, Belgium., Mouchet E; AstraZeneca BioPharmaceuticals R&D, Cambridge, UK., Singh S; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shafqat Abbasi H; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Aspesi P Jr; Chemical Biology & Therapeutics Department, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Boyd JD; Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA., Gilbert T; Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA., Gnutt D; Bayer AG, Research & Development, Pharmaceuticals, Wuppertal, Germany., Hariharan S; Discovery Sciences, Pfizer, Groton, CT, USA., Hernandez D; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hormel G; Merck Healthcare KGaA, Darmstadt, Germany., Juhani K; AstraZeneca BioPharmaceuticals R&D, Cambridge, UK., Melanson M; Center for Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mervin LH; AstraZeneca BioPharmaceuticals R&D, Cambridge, UK., Monteverde T; AstraZeneca BioPharmaceuticals R&D, Cambridge, UK., Pilling JE; AstraZeneca BioPharmaceuticals R&D, Cambridge, UK., Skepner A; Center for Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Swalley SE; Biogen, Inc., Cambridge, MA, USA., Vrcic A; Center for Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Weisbart E; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Williams G; AstraZeneca BioPharmaceuticals R&D, Cambridge, UK., Yu S; Takeda Development Center Americas, Inc., San Diego, CA, USA., Zapiec B; Merck Healthcare KGaA, Darmstadt, Germany., Carpenter AE; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA. anne@broadinstitute.org.
Publikováno v:
Nature protocols [Nat Protoc] 2023 Jul; Vol. 18 (7), pp. 1981-2013. Date of Electronic Publication: 2023 Jun 21.
Autor:
Zhu Y; Department of Clinical Chinese Pharmacy, School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing, China.; Department of Chemistry, Center for Molecular Science Informatics, University of Cambridge, Cambridge, United Kingdom.; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom., Yang H; Department of Chemistry, Center for Molecular Science Informatics, University of Cambridge, Cambridge, United Kingdom., Han L; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology, Shandong Academy of Sciences, Jinan, China.; School of Pharmacy and Pharmaceutical Science, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China., Mervin LH; Department of Chemistry, Center for Molecular Science Informatics, University of Cambridge, Cambridge, United Kingdom., Hosseini-Gerami L; Department of Chemistry, Center for Molecular Science Informatics, University of Cambridge, Cambridge, United Kingdom., Li P; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology, Shandong Academy of Sciences, Jinan, China., Wright P; Department of Chemistry, Center for Molecular Science Informatics, University of Cambridge, Cambridge, United Kingdom., Trapotsi MA; Department of Chemistry, Center for Molecular Science Informatics, University of Cambridge, Cambridge, United Kingdom., Liu K; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology, Shandong Academy of Sciences, Jinan, China., Fan TP; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom., Bender A; Department of Chemistry, Center for Molecular Science Informatics, University of Cambridge, Cambridge, United Kingdom.
Publikováno v:
Frontiers in pharmacology [Front Pharmacol] 2023 Feb 03; Vol. 14, pp. 1116081. Date of Electronic Publication: 2023 Feb 03 (Print Publication: 2023).
Autor:
Mervin, LH
MOTIVATION: In silico approaches often fail to utilize bioactivity data available for orthologous targets due to insufficient evidence highlighting the benefit for such an approach. Deeper investigation into orthologue chemical space and its influenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79f057ccd7d0325fa623d7a59cdc35e
https://www.repository.cam.ac.uk/handle/1810/267938
https://www.repository.cam.ac.uk/handle/1810/267938
Autor:
Fu, X, Mervin, LH, Li, X, Yu, H, Li, J, Mohamad Zobir, SZ, Zoufir, A, Zhou, Y, Song, Y, Wang, Z, Bender, A
One important, however, poorly understood, concept of Traditional Chinese Medicine (TCM) is that of hot, cold, and neutral nature of its bioactive principles. To advance the field, in this study, we analyzed compound-nature pairs from TCM on a large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bfa54c8c16de3e25b1502f28bfdca2
Autor:
Mervin LH; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK. lewis.mervin1@astrazeneca.com., Trapotsi MA; Department of Chemistry, Centre for Molecular Informatics, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Afzal AM; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Barrett IP; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Bender A; Department of Chemistry, Centre for Molecular Informatics, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Engkvist O; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.; Department of Computer Science and Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Publikováno v:
Journal of cheminformatics [J Cheminform] 2021 Aug 19; Vol. 13 (1), pp. 62. Date of Electronic Publication: 2021 Aug 19.
Autor:
Chama MA; Department of Chemistry, School of Physical and Mathematical Sciences, University of Ghana, Ghana. Electronic address: machama@ug.edu.gh., Modos D; Department of Chemistry, University of Cambridge, United Kingdom., Mervin LH; Department of Chemistry, University of Cambridge, United Kingdom., Owusu KB; Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana., Ayine-Tora DM; School of Chemical Sciences, The University of Auckland, New Zealand., Egyir B; Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana., Paemka L; Department of Biochemistry Cell and Molecular Biology, University of Ghana, Ghana; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Ghana., Yankson G; Department of Biochemistry Cell and Molecular Biology, University of Ghana, Ghana; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Ghana., Ohashi M; Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana., Afzal AM; Department of Chemistry, University of Cambridge, United Kingdom., Bender A; Department of Chemistry, University of Cambridge, United Kingdom.
Publikováno v:
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2021 Apr 15; Vol. 193, pp. 28-37. Date of Electronic Publication: 2021 Jan 23.
Autor:
Mervin LH; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK., Mitricheva E; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany., Logothetis NK; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.; Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK., Bifone A; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.; Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy., Bender A; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK., Noori HR; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2021 Apr; Vol. 41 (4), pp. 874-885. Date of Electronic Publication: 2020 Apr 11.
Autor:
Trapotsi MA; Department of Chemistry, Centre for Molecular Informatics, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., Mervin LH; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Afzal AM; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Sturm N; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Gothenburg SE-43183, Sweden., Engkvist O; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Gothenburg SE-43183, Sweden., Barrett IP; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Bender A; Department of Chemistry, Centre for Molecular Informatics, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
Publikováno v:
Journal of chemical information and modeling [J Chem Inf Model] 2021 Mar 22; Vol. 61 (3), pp. 1444-1456. Date of Electronic Publication: 2021 Mar 04.
Autor:
Mervin LH; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK. Electronic address: lewis.mervin1@astrazeneca.com., Johansson S; Department of Computer Science and Engineering, Chalmers University of Technology, Gothenburg, Sweden; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Semenova E; Data Sciences and Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Giblin KA; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK., Engkvist O; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
Publikováno v:
Drug discovery today [Drug Discov Today] 2021 Feb; Vol. 26 (2), pp. 474-489. Date of Electronic Publication: 2020 Nov 27.