Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mervi Vasänge"'
Autor:
Mervi Vasänge
Publikováno v:
Planta Medica. 80:1200-1209
Phenotypic and target-based approaches represent two principal strategies for identifying new bioactive compounds. In this review, differences between these approaches, as well as strengths and limitations thereof, are described by examples from the
Autor:
Can Slivo, Jonas Malmström, Mervi Vasänge, Mickaël Maudet, Stefan Geschwindner, Gösta Hiller, Yafeng Xue, Jenny Viklund, Catrin Sandelin, Lise-Lotte Olsson, Ana Rodrigues Costa, Anna Aagaard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5919-5923
4-(1,3-Benzothiazol-2-yl)thiophene-2-sulfonamide (4a) was found to be a moderately potent inhibitor of cyclin-dependent kinase 5 (cdk5) from a HTS screen. The synthesis and SAR around this hit is described. The X-ray coordinates of ligand 4a with cdk
Autor:
Gösta Hiller, Jan Ottervald, Gang Liu, Ann-Cathrin Radesäter, Mervi Vasänge, Karin Agerman, Anne Jämsä, Jonas Malmström
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 16, Iss 1, p 55 (2009)
Journal of Biomedical Science, Vol 16, Iss 1, p 55 (2009)
Background Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is the lack of reproducible and wel
Publikováno v:
Neuroreport. 17(9)
The hallmarks of Alzheimer's disease include extracellular plaques primarily consisting of amyloid-beta peptide and intracellular neurofibrillary tangles composed of highly phosphorylated tau protein. We report that exposure of organotypic hippocampa
Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells
Autor:
Nodi Dehvari, Anders Bäckström, Elin Gustafsson, Richard F. Cowburn, Gösta Hiller, Anne Jämsä, Mervi Vasänge
Publikováno v:
Biochemical and biophysical research communications. 345(1)
Neurofibrillary tangles (NFT) of hyperphosphorylated tau protein are a major pathological hallmark of Alzheimer’s disease (AD). One of the tau phosphorylating kinases with pathological relevance in AD has been suggested to be the cyclin-dependent k
Autor:
Per-Göran Gillberg, Ali-Reza Modiri, Mervi Vasänge, Staffan Sundquist, S. S. Jossan, Peteris Alberts
Publikováno v:
European journal of pharmacology. 451(2)
The present study was done to characterize a new compound, PNU-171990, 2-diisopropyl aminoethyl 1-phenylcyclopentane carboxylate hydrochloride, with functional smooth muscle selectivity at least as high as tolterodine. In vitro homogenates of guinea