Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Mervi Detorio"'
Autor:
Hetal K Patel, Sunday Ikpe, Megan Bronson, Sehin Birhanu, Alash'le Abimiku, Ibrahim Jahun, Mervi Detorio, Kathryn Lupoli, Daniel Yavo, Orji O Bassey, Tapdiyel D Jelpe, Brian Kagurusi, Nnaemeka C Iriemenam, Divya Patel, McPaul I Okoye, Ibrahim T Dalhatu, Stephen Ohakanu, Andrew C Voetsch, Sani Aliyu, Gregory Ashefor, Aliyu Gambo, Gabriel O Ikwulono, Charles Nzelu, Isaac F Adewole, Mahesh Swaminathan, Bharat Parekh
Publikováno v:
PLOS Global Public Health, Vol 2, Iss 7, p e0000466 (2022)
BackgroundThe Nigeria AIDS Indicator and Impact Survey (NAIIS), a cross-sectional household survey, was conducted in 2018 with primary objectives to estimate HIV prevalence, HIV-1 incidence, and status of UNAIDS 90-90-90 cascade. We conducted retrosp
Externí odkaz:
https://doaj.org/article/283f65e153ac455c9e5a4970eab74b1d
Autor:
Ernest L Yufenyuy, Mervi Detorio, Trudy Dobbs, Hetal K Patel, Keisha Jackson, Shanmugam Vedapuri, Bharat S Parekh
Publikováno v:
PLOS Global Public Health, Vol 2, Iss 5, p e0000316 (2022)
We previously described development of a rapid test for recent infection (RTRI) that can diagnose HIV infection and detect HIV-1 recent infections in a single device. This technology was transferred to a commercial partner as Asante Rapid Recency Ass
Externí odkaz:
https://doaj.org/article/26784b061ce84b889f35d05a7a68d60c
Autor:
Frehywot Eshetu, Hetal Patel, Ernest L. Yufenyuy, Assegid Mengistu, Yohannes Mengistu, Andrew C. Voetsch, Paul Stupp, Kristin Brown, Owen Mugurungi, Daniel B Williams, Godfrey Musuka, Fred Asiimwe, Munyaradzi Pasipamire, Emily Kainne Dokubo, John N Kiiru, Mervi Detorio, Stephen McCracken, Prisca Chikwanda, Roger Lobognon, Dorothy Aibo, Andrew Kabala, George S Mgomella, Sam Biraro, Clement B. Ndongmo, Shirish Balachandra, Sindisiwe Dlamini, Bharat Parekh, Optatus Malewo, Jennifer Ward, Anne-Cécile Zoung-Kanyi Bissek, Harriet Nuwagaba-Biribonwoha, Elizabeth Kampira, Belete Tegbaru, Laura T. Eno, Judith Shang, Frieda S Winterhalter, Muthoni Junghae, Yen T Duong, Richard C N Mwesigwa, Trudy Dobbs, Leonard Kingwara, Jeremiah Mushi, Suzue Saito, Danielle Payne
Publikováno v:
J Acquir Immune Defic Syndr
Background HIV-1 incidence calculation currently includes recency classification by HIV-1 incidence assay and unsuppressed viral load (VL ≥ 1000 copies/mL) in a recent infection testing algorithm (RITA). However, persons with recent classification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff25626f1cbe94350c36ee8fc7629630
https://doi.org/10.1097/qai.0000000000002707
https://doi.org/10.1097/qai.0000000000002707
Autor:
Raymond F. Schinazi, Mervi Detorio, Catherine Montero, Masood Parvez, Zunera Khalid, Sana Aslam, Matloob Ahmad, Munawar Ali Munawar
Publikováno v:
Med Chem Res
A series of fifteen new 2-[3-(3-chlorophenyl)-5,5-dioxidobenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(2H)-yl]-N′-arylmethyleneacetohydrazides (5a–o) were synthesized and screened for their anti-HIV-1 and cytotoxicity activity. Out of fifteen pyrazoloben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c29e06f77e3456b19d1af9c75678f45
https://pubmed.ncbi.nlm.nih.gov/34316244
https://pubmed.ncbi.nlm.nih.gov/34316244
Autor:
Steven J. Coats, Grigorii G. Sivets, Tami R. McBrayer, Mervi Detorio, Tony Whitaker, Raymond F. Schinazi, Franck Amblard
Publikováno v:
Heterocycl Comm
The synthesis of new 2,6-disubstituted purine 2′,3′-dideoxy-2′,3′-difluoro-D-arabino nucleosides is reported. Their ability to block HIV and HCV replication along with their cytotoxicity toward Huh-7 cells, human lymphocyte, CEM and Vero cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c3f8e6aa1e957352e21bc96e41fe23
https://pubmed.ncbi.nlm.nih.gov/34316093
https://pubmed.ncbi.nlm.nih.gov/34316093
Autor:
Tafadzwa Dzinamarira, Paul Rubinstein, Sehin Birhanu, Daniel Yavo, Ernest L. Yufenyuy, Shanmugam Vedapuri, Andrew C. Voetsch, Karampreet Sachathep, Yen T Duong, Katrina Sleeman, Kristin Brown, Floris Wray-Gordon, Melissa Metz, Clement B. Ndongmo, Trudy Dobbs, Suzue Saito, Robert A. Domaoal, Keisha Jackson, Kathryn Lupoli, Mervi Detorio, Carole Moore, Hetal Patel, Herbert Longwe, Bharat Parekh, Julius Manjengwa, Francis M Ogollah
Publikováno v:
Journal of acquired immune deficiency syndromes (1999). 87(Suppl 1)
BACKGROUND Conducting HIV surveys in resource-limited settings is challenging because of logistics, limited availability of trained personnel, and complexity of testing. We described the procedures and systems deemed critical to ensure high-quality l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0967c4932c79328ff7c54be742340c
https://pubmed.ncbi.nlm.nih.gov/34166309
https://pubmed.ncbi.nlm.nih.gov/34166309
Autor:
Catherine Montero, James H. Nettles, Mervi Detorio, Emily T. Hammond, Michel Feraud, Raymond F. Schinazi, Richard A. Stanton, Robert A. Domaoal, Maryam Ehteshami, Xiao Lu
Publikováno v:
Bioorg Med Chem Lett
A library of 585 compounds built off a 7-azaindole core was evaluated for anti-HIV-1 activity, and ten hits emerged with submicromolar potency and therapeutic index >100. Of these, three were identified as non-nucleoside reverse transcriptase (RT) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396e39f3d7a0a94beb69b0ca239ac7c8
https://doi.org/10.1016/j.bmcl.2016.06.065
https://doi.org/10.1016/j.bmcl.2016.06.065
Autor:
Mervi Detorio, Vicente Planelles, Raymond F. Schinazi, Catherine Montero, Christina Gavegnano, Alberto Bosque
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:1977-1986
The JAK-STAT pathway is activated in both macrophages and lymphocytes upon human immunodeficiency virus type 1 (HIV-1) infection and thus represents an attractive cellular target to achieve HIV suppression and reduced inflammation, which may impact v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb7af6a34efcc5fd4092865d3b12392
https://doi.org/10.1128/aac.02496-13
https://doi.org/10.1128/aac.02496-13
Autor:
John M. Gardiner, Sana Aslam, Usman Ali Ashfaq, Muhammad Makshoof Athar, Matloob Ahmad, Catherine Montero, Raymond F. Schinazi, Mervi Detorio, Masood Parvez
Publikováno v:
Medicinal Chemistry Research. 23:2930-2946
N′-Substitutedbenzylidene-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazides (7a–u) were synthesized through a multistep reaction. The final compounds were screened for anti-HIV-1 and cytotoxic activities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab847f91b30ce8f76f51421eca810765
https://doi.org/10.1007/s00044-013-0879-7
https://doi.org/10.1007/s00044-013-0879-7
Autor:
Catherine Montero, Sana Aslam, Masood Parvez, Mujahid Hussain Bukhari, Matloob Ahmad, Mervi Detorio, Raymond F. Schinazi
Publikováno v:
Medicinal Chemistry Research. 23:1309-1319
A new series of pyrazolobenzothiazine-based carbohydrazides was prepared in a facile way, starting with commercially available sodium saccharine. The final products were sufficiently characterized by spectroscopic techniques. In addition, compound 5k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ce7908cc9377f065ba05c88a34f1055
https://doi.org/10.1007/s00044-013-0718-x
https://doi.org/10.1007/s00044-013-0718-x