Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mervat Z, Mohamed"'
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-5 (2024)
The possible protective effect of sitagliptin (SIT) against nephrotoxicity induced by a single dose 5-fluorouracil (5-FU) (150 mg/kg, i.p.) was investigated in rats. SIT treatment (5 and 10 mg/kg/day, p.o.) was given for 7 days, starting 5 days befor
Externí odkaz:
https://doaj.org/article/370f09ec151a4595a344de267fac2814
Autor:
Mohamed A. Morsy, Seham A. Abdel-Gaber, Sahar A. Mokhemer, Mahmoud Kandeel, Wael F. Sedik, Anroop B. Nair, Katharigatta N. Venugopala, Hany Ezzat Khalil, Bandar E. Al-Dhubiab, Mervat Z. Mohamed
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 665 (2023)
The clinical usefulness of doxorubicin (DOX) is limited by its serious adverse effects, such as cardiotoxicity. Pregnenolone demonstrated both anti-inflammatory and antioxidant activity in animal models. The current study aimed to investigate the car
Externí odkaz:
https://doaj.org/article/9fa69729efb9480dbde210f6f11d1777
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 100:176-183
Acute pancreatitis (AP) is an abrupt inflammatory disorder causing high morbidity and mortality. As AP is an insidious medical emergency, a curative modality is required instead of a preventive measure. Thus, we investigated the possible curative eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f049e46cf9009debc153b800a870b51d
https://doi.org/10.1139/cjpp-2021-0330
https://doi.org/10.1139/cjpp-2021-0330
Publikováno v:
Life sciences. 294
Aprepitant, a neurokinin-1 (NK1) receptor antagonist, is a clinically approved anti-emetic drug. Recently, inhibition of the NK1 receptor has been reported as a potential nephroprotective strategy. We aimed to assess the pharmacological mechanisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1fe3b73ef849df196c14d4fb90b842
https://pubmed.ncbi.nlm.nih.gov/35143828
https://pubmed.ncbi.nlm.nih.gov/35143828
Autor:
Mervat Z. Mohamed, Hanaa H. Mohammed
Publikováno v:
Drug and chemical toxicology. 45(6)
Fluorouracil (5-FU) is a widely used chemotherapeutic agent in various malignant tumors. However, intestinal toxicity is considered the irritant unavoidable adverse effect during the course therapy. The aim of the current study was to screen the effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c54f4de71a236f7eb6c6a8551e2c44e
https://pubmed.ncbi.nlm.nih.gov/34747284
https://pubmed.ncbi.nlm.nih.gov/34747284
Publikováno v:
Toxicology and Applied Pharmacology. 457:116313
Cadmium (Cd) has potential hazards on human beings. Consequently, this study was performed to explore the protective effects of agomelatine (AGO), a melatonin receptor agonist, against Cd-induced toxicity in rats. AGO (40 mg/kg/day) was administered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effaaae3716c32af41e6783abd3686ba
https://doi.org/10.1016/j.taap.2022.116313
https://doi.org/10.1016/j.taap.2022.116313
Publikováno v:
Environmental Toxicology and Pharmacology. 95:103940
Bleomycin is a well-recognized antineoplastic drug. However, pulmonary fibrosis (PF) is considered to be the principal drawback that greatly limits its use. Here, we sought to investigate ability of the neurokinin receptor 1 blocker, aprepitant, to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb71a4e794759fc2b81f71f30986147
https://doi.org/10.1016/j.etap.2022.103940
https://doi.org/10.1016/j.etap.2022.103940
Autor:
Nagwa M. Zenhom, Heba M. Hafez, Mohamad A Ibrahim, Hend M Abd Elghany, Mervat Z. Mohamed, Marwa Hassan
Publikováno v:
Current Clinical Pharmacology. 14:61-67
Background:Cilostazol, a phosphodiesterase 3 inhibitor (PDE3I), is a platelet aggregation inhibitor and vasodilator that is useful for treating intermittent claudication. Experimental studies have shown that cilostazol has potent anti-inflammatory, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5b62c23c2db51336eddda9c7e7ea4b
https://doi.org/10.2174/1574884713666180903163558
https://doi.org/10.2174/1574884713666180903163558
Publikováno v:
Canadian journal of physiology and pharmacology. 99(3)
Activation of hepatic stellate cells is a central event in hepatic fibrogenesis that offers multiple potential sites for therapeutic interventions. Peroxisome proliferator-activated receptors are implicated in liver fibrosis. We aimed to evaluate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cca6aa7d24589b54f7956dbf8d55df
https://pubmed.ncbi.nlm.nih.gov/32721217
https://pubmed.ncbi.nlm.nih.gov/32721217
Publikováno v:
Humanexperimental toxicology. 39(9)
Endometrial hyperplasia (EH) is a medical condition that affects many females as it increases their uterine carcinogenic potential. EH results from entangling hormonal imbalance and inflammatory response. The study examined the role of a xanthine oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63df8f4b83e0913727f50c4eb92af9d5
https://pubmed.ncbi.nlm.nih.gov/32228192
https://pubmed.ncbi.nlm.nih.gov/32228192