Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Meruyert Kudaibergenova"'
Autor:
Meruyert Kudaibergenova, Jiqing Guo, Hanif M. Khan, Farhan Zahid, James Lees-Miller, Sergei Yu. Noskov, Henry J. Duff
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Human-ether-a-go-go-related channel (hERG1) is the pore-forming domain of the delayed rectifier K+ channel in the heart which underlies the IKr current. The channel has been extensively studied due to its propensity to bind chemically diverse group o
Externí odkaz:
https://doaj.org/article/879c8e1fbdac4643966727b7d6174254
Autor:
Meruyert Kudaibergenova, Jiqing Guo, Hanif M. Khan, James Lees-Miller, Mahdi Mousaei, Williams Miranda, Van A. Ngo, Sergei Yu Noskov, D. Peter Tieleman, Henry J. Duff
Publikováno v:
Biophysical Journal. 121:4585-4599
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::895d852b87ba1d2943131dcfe5ebfb59
https://doi.org/10.1016/j.bpj.2022.10.032
https://doi.org/10.1016/j.bpj.2022.10.032
Publikováno v:
J Chem Inf Model
Drug-induced cardiotoxicity is a potentially lethal and yet one of the most common side effects with the drugs in clinical use. Most of the drug-induced cardiotoxicity is associated with an off-target pharmacological blockade of K(+) currents carried
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fd1b425bceef5f819a9d2a4066ddfb
https://europepmc.org/articles/PMC7839320/
https://europepmc.org/articles/PMC7839320/
Autor:
German L. Perlovich, Laura L. Perissinotti, James Paul Lees-Miller, Meruyert Kudaibergenova, Marina V. Ol’khovich, Sergei Y. Noskov, Jiqing Guo, Angelica V. Sharapova, Daniel A. Muruve, Henry J. Duff, Brenda Gerull
Publikováno v:
Mol Pharmacol
Abnormal cardiac electrical activity is a common side effect caused by unintended block of the promiscuous drug target human ether-à-go-go-related gene (hERG1), the pore-forming domain of the delayed rectifier K(+) channel in the heart. hERG1 block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9541e3deb855479138090ca2c4d1bcb3
https://pubmed.ncbi.nlm.nih.gov/31182542
https://pubmed.ncbi.nlm.nih.gov/31182542
Autor:
Haydee Mesa Galloso, Valentina Corradi, Nandhitha Subramanian, Peter Tieleman, Sara I. Liin, Meruyert Kudaibergenova, Mario E. Valdés-Tresanco, Peter Larsson, Sergei Y. Noskov, Williams E. Miranda
Publikováno v:
Biophysical Journal. 118:555a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b18c1f7f6450909ead40931692a3b34c
https://doi.org/10.1016/j.bpj.2019.11.3032
https://doi.org/10.1016/j.bpj.2019.11.3032
Publikováno v:
Neuroscience letters. 700
Human-ether-a-go-go-related channel (hERG) is a voltage gated potassium channel (Kv11.1) abundantly expressed in heart and brain tissues. In addition to playing an important role in mediation of repolarizing K+ currents (IKr) in Action Potential (AP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e00bbeaf242383744cf5e0eed78291
https://pubmed.ncbi.nlm.nih.gov/29758301
https://pubmed.ncbi.nlm.nih.gov/29758301
Publikováno v:
Biophysical Journal. 114:293a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aabd54ac0e223ac83591c9ed5baa209b
https://doi.org/10.1016/j.bpj.2017.11.1676
https://doi.org/10.1016/j.bpj.2017.11.1676