Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis.

Autor: Wang S; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Rao W; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Hoffman A; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Lin J; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Li J; AccuraScience, Johnston, IA 50131, USA., Lin T; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Liew AA; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Vincent M; Nuwa Medical Systems, Houston, TX 77479, USA., Mertens TCJ; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Karmouty-Quintana H; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Crum CP; Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02215, USA., Metersky ML; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Connecticut School of Medicine, Farmington, CT 06032, USA., Schwartz DA; Departments of Medicine and Microbiology and Immunology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Davies PJA; Texas A&M Health Institute of Biotechnology, Houston, TX 77030, USA., Stephan C; Texas A&M Health Institute of Biotechnology, Houston, TX 77030, USA., Jyothula SSK; Lung Transplant Center at Memorial Hermann-Texas Medical Center, Houston, TX 77030, USA., Sheshadri A; Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Suarez EE; Department of Medicine, Houston Methodist Hospital, Houston, TX 77030, USA., Huang HJ; Department of Medicine, Houston Methodist Hospital, Houston, TX 77030, USA., Engelhardt JF; Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Dickey BF; Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Parekh KR; Department of Surgery, Division of Cardiothoracic Surgery, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., McKeon FD; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Xian W; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Apr 26; Vol. 15 (693), pp. eabp9528. Date of Electronic Publication: 2023 Apr 26.

Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis.

Autor: Rao W; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Wang S; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Duleba M; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Niroula S; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Goller K; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Xie J; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Mahalingam R; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Neupane R; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Liew AA; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA., Vincent M; Nüwa Medical Systems, Houston, TX 77479, USA., Okuda K; Marsico Lung Center, University of North Carolina, Chapel Hill, NC 27599, USA., O'Neal WK; Marsico Lung Center, University of North Carolina, Chapel Hill, NC 27599, USA., Boucher RC; Marsico Lung Center, University of North Carolina, Chapel Hill, NC 27599, USA., Dickey BF; Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wechsler ME; Department of Medicine, National Jewish Health, Denver, CO 80206, USA., Ibrahim O; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Connecticut School of Medicine, Farmington, CT 06032, USA., Engelhardt JF; Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Mertens TCJ; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Wang W; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Jyothula SSK; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Crum CP; Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02215, USA., Karmouty-Quintana H; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Parekh KR; Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Department of Surgery, Division of Cardiothoracic Surgery, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Metersky ML; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Connecticut School of Medicine, Farmington, CT 06032, USA., McKeon FD; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA. Electronic address: fdmckeon@uh.edu., Xian W; Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA. Electronic address: wxian@uh.edu.

Publikováno v: Cell [Cell] 2020 May 14; Vol. 181 (4), pp. 848-864.e18. Date of Electronic Publication: 2020 Apr 15.

Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells.

Autor: Ali MN; Respiratory Medicine & Allergology, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden. Mohamad.Ali@med.lu.se., Mori M; Unit of Airway Inflammation, Department of Experimental Medical Sciences, Lund University and Skåne University Hospital, Lund, Sweden., Mertens TCJ; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX, USA., Siddhuraj P; Unit of Airway Inflammation, Department of Experimental Medical Sciences, Lund University and Skåne University Hospital, Lund, Sweden., Erjefält JS; Unit of Airway Inflammation, Department of Experimental Medical Sciences, Lund University and Skåne University Hospital, Lund, Sweden., Önnerfjord P; Rheumatology & Molecular Skeletal Biology, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden., Hiemstra PS; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands., Egesten A; Respiratory Medicine & Allergology, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden.

Publikováno v: Scientific reports [Sci Rep] 2019 Oct 29; Vol. 9 (1), pp. 15566. Date of Electronic Publication: 2019 Oct 29.

Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema.

Autor: Collum SD; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Molina JG; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Hanmandlu A; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Bi W; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Pedroza M; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA., Mertens TCJ; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Wareing N; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Wei W; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Wilson C; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Sun W; Biomaterials and Advanced Drug Delivery Lab, Stanford University School of Medicine, Stanford, CA 94304, USA., Rajadas J; Biomaterials and Advanced Drug Delivery Lab, Stanford University School of Medicine, Stanford, CA 94304, USA., Bollyky PL; Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Philip KM; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Ren D; Houston Methodist DeBakey Transplant Center, Houston Methodist Hospital, Houston, TX 77030, USA., Thandavarayan RA; Houston Methodist DeBakey Transplant Center, Houston Methodist Hospital, Houston, TX 77030, USA., Bruckner BA; Houston Methodist DeBakey Transplant Center, Houston Methodist Hospital, Houston, TX 77030, USA., Xia Y; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Blackburn MR; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Karmouty-Quintana H; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA harry.karmouty@uth.tmc.edu.

Publikováno v: Disease models & mechanisms [Dis Model Mech] 2019 May 15; Vol. 12 (5). Date of Electronic Publication: 2019 May 15.

Low-dose administration of bleomycin leads to early alterations in lung mechanics.

Autor: Headley L; Department of Biochemistry and Molecular Biology, McGovern Medical School, UTHealth, Houston, TX, USA.; Department of Pharmacology and Therapeutics, King's College London, London, UK., Bi W; Department of Biochemistry and Molecular Biology, McGovern Medical School, UTHealth, Houston, TX, USA., Wilson C; Department of Biochemistry and Molecular Biology, McGovern Medical School, UTHealth, Houston, TX, USA., Collum SD; Department of Biochemistry and Molecular Biology, McGovern Medical School, UTHealth, Houston, TX, USA., Chavez M; Department of Biochemistry and Molecular Biology, McGovern Medical School, UTHealth, Houston, TX, USA., Darwiche T; Department of Biochemistry and Molecular Biology, McGovern Medical School, UTHealth, Houston, TX, USA., Mertens TCJ; Department of Biochemistry and Molecular Biology, McGovern Medical School, UTHealth, Houston, TX, USA., Hernandez AM; Department of Biochemistry and Molecular Biology, McGovern Medical School, UTHealth, Houston, TX, USA., Siddiqui SR; Department of Pediatrics, Division of Critical Care Medicine, McGovern Medical School, UTHealth, Houston, TX, USA., Rosenbaum S; SCIREQ, an Emka technologies company, Montreal, QC, Canada., Johnston RA; Department of Pediatrics, Division of Critical Care Medicine, McGovern Medical School, UTHealth, Houston, TX, USA., Karmouty-Quintana H; Department of Biochemistry and Molecular Biology, McGovern Medical School, UTHealth, Houston, TX, USA.

Publikováno v: Experimental physiology [Exp Physiol] 2018 Dec; Vol. 103 (12), pp. 1692-1703. Date of Electronic Publication: 2018 Oct 17.