Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats

Autor: Alan S. Verkman, Cristina Esteva-Font, Sadik Taskin Tas, Tao Su, Marc O. Anderson, Sujin Lee, Onur Cil, Mert Ertunc

Publikováno v: Kidney international
Verkman, Alan; Cil, O; Esteva-Font, C; Tas, ST; Su, T; Lee, S; et al.(2015). Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6gv4v75n

Inhibitors of kidney urea transporter (UT) proteins have potential use as salt-sparing diuretics (‘urearetics’) with a different mechanism of action than diuretics that target salt transporters. To study UT inhibition in rats, we screened about 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0a9be2c4e134111093fa5236015aaf
https://doi.org/10.1038/ki.2015.138

Exercise and suspension hypokinesia-induced alterations in mechanical properties of rat fast and slow-twitch skeletal muscles

Autor: Rustu Onur, Mert Ertunc, Murat Yildirim, A. Atalay

Publikováno v: Acta Physiologica Hungarica. 97:316-325

Physical activity has a modulatory role on regulatory steps of excitation-contraction coupling (ECC) determining skeletal muscle contractility. We evaluated and compared the contractile responsiveness and caffeine-induced contractures of fast (extens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a9c04dda590e22748fca64e3860af1
https://doi.org/10.1556/aphysiol.97.2010.3.8

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

Autor: Rhonda Bassel-Duby, John McAnally, Mi Sung Kim, James A. Richardson, Ana C. Barbosa, Ege T. Kavalali, Megumi Adachi, Eric N. Olson, Erika D. Nelson, Mert Ertunc, Lisa M. Monteggia

Publikováno v: Proceedings of the National Academy of Sciences. 105:9391-9396

Learning and memory depend on the activity-dependent structural plasticity of synapses and changes in neuronal gene expression. We show that deletion of the MEF2C transcription factor in the CNS of mice impairs hippocampal-dependent learning and memo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e58fa7c2c392304b1d3809cc87b3e70
https://doi.org/10.1073/pnas.0802679105

Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving KATP channels

Autor: Ulkem Erkent, Alper B. Iskit, Rustu Onur, Mustafa Ilhan, M. Oguz Guc, Mert Ertunc

Publikováno v: Vascular Pharmacology. 46:129-136

The role of KATP channels in the antiarrhythmic effect of Escherichia coli endotoxin-induced nitric oxide synthase (iNOS) was examined in an anesthetised rat model of myocardial ischemia and reperfusion arrhythmia by using glibenclamide (1 mg kg− 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f57fc7df3f3c52e089474af2dbc1b06
https://doi.org/10.1016/j.vph.2006.08.415

The role of nitric oxide on contractile impairment during endotoxemia in rat diaphragm muscle

Autor: Yildirim Sara, Mert Ertunc, Rustu Onur

Publikováno v: European Journal of Pharmacology. 505:177-186

We examined the contribution of nitric oxide (NO) on the contractile impairment in diaphragm muscles of endotoxemic rats. Force-frequency relationship was depressed 24 h after lipopolysaccharide administration. 7-Nitroindazole, aminoguanidine and 1H-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd60388c4944961cbf5b5e0a38d2c3b
https://doi.org/10.1016/j.ejphar.2004.10.014