Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mert Burak Ozturk"'
Autor:
Xueyong Xu, Yinghui Li, Sakshibeedu R. Bharath, Mert Burak Ozturk, Matthew W. Bowler, Bryan Zong Lin Loo, Vinay Tergaonkar, Haiwei Song
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Incessant telomere synthesis in cancer cells depends on specific mutations in the TERT promoter, enabling its activation by transcription factors ETS1 and p52. Here, the authors elucidate the structural basis for p52/ETS1 binding to mutant TERT, sugg
Externí odkaz:
https://doaj.org/article/26d841da334f432d89039230bd2c2068
Autor:
Bilge Debelec-Butuner, Mert Burak Ozturk, Ozgur Tag, Ismail Hakki Akgun, Erdal Bedir, Kemal Sami Korkmaz
Publikováno v:
Proceedings, Vol 1, Iss 10, p 985 (2017)
Inhibition of inflammation-induced carcinogenesis is an efficient therapeutic strategy for cancer chemoprevention as use of anti-inflammatories was reported to decrease the cancer risk. In this study, we aimed to investigate the inhibition potential
Externí odkaz:
https://doaj.org/article/acce2ce237574feeae1db16a1328b3fa
Publikováno v:
Antioxidants, Vol 6, Iss 1, p 17 (2017)
The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and senescence of normal somatic cells as well as cancer cells. This complex is comprised mainly of telomerase reverse transcriptase (TERT), telomerase RNA co
Externí odkaz:
https://doaj.org/article/743b9a2785074932bc0a03be22c50433
Autor:
Sebastian Maurer-Stroh, Ashar Malik, Dimitar Kenanov, Cheng-Shoong Chong, Mert Burak Ozturk, Maxime Hebrard, Ying Swan Ho, Zhenxun Wang, Vachiranee Limviphuvadh, Jhoann Miyajima, Roberto Magallanes, Xueling Sim, Jin Fang Chai, Sonia Davila, Khung Keong Yeo, Khai Pang Leong, Liuh Ling Goh, Neerja Karnani, Johan Gunnar Eriksson, Ching-Yu Cheng, Tien Wong, Marie Loh, Rinkoo Dalan, Chiea Chuen Khor, Guo-Liang Chew, Weng Khong Lim, Joanne Ngeow, John Chambers, E Shyong Tai, Nicolas Bertin, Chris Soon Heng Tan, Judice Koh, Patrick Tan, Chandra Verma
One of the promises of precision medicine is to understand and act on inter-individual genetic differences in drug responses. SNPdrug3D contains the complete genomic landscape of missense single nucleotide variants (SNV) across the human proteome and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dea066a53ae7a448d8ac2483b836a175
https://doi.org/10.21203/rs.3.rs-2377190/v1
https://doi.org/10.21203/rs.3.rs-2377190/v1
Autor:
Raghuvaran Shanmugam, Mert Burak Ozturk, Joo-Leng Low, Semih Can Akincilar, Joelle Yi Heng Chua, Matan Thangavelu Thangavelu, Giridharan Periyasamy, Ramanuj DasGupta, Vinay Tergaonkar
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Mutations in hTERT promoter are seen in over 19% of human cancers, irrespective of the cancer type. Understanding the molecular players that regulate Mut-hTERT promoters may help the design of effective targeting strategies to inhibit te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50d8619f3a4f5939ed7d95981748539
http://europepmc.org/articles/PMC8784157
http://europepmc.org/articles/PMC8784157
Autor:
Çiğdem Yengin, Bintuğ Öztürk, Bilge Debeleç Bütüner, Fadime Aydoğan, Sura Baykan, Mert Burak Ozturk
FerulaL. is representedby 23 taxa in Turkish flora. Most of the species are known as “Caksır” and roots are used as aphrodisiac in Anatolia. the aim of this study is to investigate the cytotoxic potential of roots of twelve different FerulaL. sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d14b55a7c3c3249a5dc7b12a3f85185
https://hdl.handle.net/11454/80953
https://hdl.handle.net/11454/80953
Autor:
Matthew W. Bowler, Haiwei Song, Vinay Tergaonkar, Bryan Zong Lin Loo, Xueyong Xu, Yat Li, Sakshibeedu R. Bharath, Mert Burak Ozturk
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
'Nature Communications ', vol: 9, pages: 3183-1-3183-10 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
'Nature Communications ', vol: 9, pages: 3183-1-3183-10 (2018)
Transcriptional factors ETS1/2 and p52 synergize downstream of non-canonical NF-κB signaling to drive reactivation of the −146C>T mutant TERT promoter in multiple cancer types, but the mechanism underlying this cooperativity remains unknown. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e417b5643d501c28e5a24d7041a43c5f
http://europepmc.org/articles/PMC6085347
http://europepmc.org/articles/PMC6085347
Autor:
Xavier Bisteau, Nayana Prabhu, Radoslaw M. Sobota, Pär Nordlund, Johan Lengqvist, Vinay Tergaonkar, Lingyun Dai, Yan Ting Lim, Lekshmy Sreekumar, Chern Han Yong, Philipp Kaldis, Chris Soon Heng Tan, Ka Diam Go, Mert Burak Ozturk
Publikováno v:
Science, 359 (6380
Proteins differentially interact with each other across cellular states and conditions, but an efficient proteome-wide strategy to monitor them is lacking. We report the application of thermal proximity coaggregation (TPCA) for high-throughput intrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286bb3fc6116b23f68d95095bfde77d8
http://hdl.handle.net/10220/48481
http://hdl.handle.net/10220/48481
Autor:
Kemal Sami Korkmaz, Ismail Hakki Akgun, Erdal Bedir, Ozgur Tag, Mert Burak Ozturk, Bilge Debelec-Butuner, Gunay Yetik-Anacak
PubMed: 29678446
2-s2.0-85046477155
Chronic inflammation is associated to 25% of cancer cases according to epidemiological data. Therefore, inhibition of inflammation-induced carcinogenesis can be an efficient therapeutic approach for cance
2-s2.0-85046477155
Chronic inflammation is associated to 25% of cancer cases according to epidemiological data. Therefore, inhibition of inflammation-induced carcinogenesis can be an efficient therapeutic approach for cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f62d90af317fc4d453f24ad20e07b5c
https://aperta.ulakbim.gov.tr/record/33299
https://aperta.ulakbim.gov.tr/record/33299
Autor:
Erdal Bedir, Kemal Sami Korkmaz, Mert Burak Ozturk, Ozgur Tag, Ismail Hakki Akgun, Bilge Debelec-Butuner
Publikováno v:
Proceedings, Vol 1, Iss 10, p 985 (2017)
Inhibition of inflammation-induced carcinogenesis is an efficient therapeutic strategy for cancer chemoprevention as use of anti-inflammatories was reported to decrease the cancer risk. In this study, we aimed to investigate the inhibition potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffaf4ece4601d5582c2839d45ad12e8
https://www.mdpi.com/2504-3900/1/10/985
https://www.mdpi.com/2504-3900/1/10/985