Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Merryl D. Cramer"'
Autor:
Mark W. Holladay, Shripad S. Bhagwat, Michael Williams, Bruce D. Dorsey, Raffaella Faraoni, Julius L. Apuy, Mark A. Ator, Darren E. Insko, Mehran Yazdanian, Dana Gitnick, Mangeng Cheng, Ronald R. Nepomuceno, Kathryn Hunter, Merryl D. Cramer, Hugh Zhao, Michael F. Gardner, Pawel Dobrzanski, Ruwanthi N. Gunawardane, Susan Jones-Bolin, Martin W. Rowbottom, Robert C. Armstrong, Bruce Ruggeri, Joyce James
PDF file - 74K, CEP-32496 Supplemental Data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e595ddea4dcb7e0d0c551afc2da871ae
https://doi.org/10.1158/1535-7163.22498993.v1
https://doi.org/10.1158/1535-7163.22498993.v1
Autor:
Michael J. Hadd, Helen Hua, Gang Liu, Dana Gitnick, Troy D. Vickers, Lan Tran, Janice A. Sindac, Joyce James, Zdravko V. Milanov, Robert C. Armstrong, Daniel K. Treiber, Mark W. Holladay, Julia M. Ford Pulido, Merryl D. Cramer, Barbara Belli, Shripad Bhagwat, Alan Dao, Sunny Abraham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5296-5300
The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound 1 resulted in analogs with high cellular activity and improved rat PK p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97442310ba09dc49a99ab34d58bc3932
https://doi.org/10.1016/j.bmcl.2011.07.027
https://doi.org/10.1016/j.bmcl.2011.07.027
Autor:
Hitesh K. Patel, Kelly G. Sprankle, Michael F. Gardner, Shripad Bhagwat, Qi Chao, Ruwanthi N. Gunawardane, Patrick P. Zarrinkar, Gabriel Pallares, Keith W. Pratz, Robert C. Armstrong, Barbara Belli, Joyce James, Daniel Brigham, Mark J. Levis, Merryl D. Cramer, Mazen W. Karaman
Publikováno v:
Blood. 114:2984-2992
Activating mutations in the receptor tyrosine kinase FLT3 are present in up to approximately 30% of acute myeloid leukemia (AML) patients, implicating FLT3 as a driver of the disease and therefore as a target for therapy. We report the characterizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba019ff310639591bcc5e2721360aa6
https://doi.org/10.1182/blood-2009-05-222034
https://doi.org/10.1182/blood-2009-05-222034
Autor:
Shripad Bhagwat, Anne Marie Velasco, Joyce James, Qi Chao, Todd A. Carter, Andiliy G. Lai, Robert M. Grotzfeld, Michael F. Gardner, Patrick P. Zarrinkar, Ruwanthi N. Gunawardane, Kelly G. Sprankle, Hitesh K. Patel, Merryl D. Cramer
Publikováno v:
Journal of Medicinal Chemistry. 52:7808-7816
Treatment of AML patients with small molecule inhibitors of FLT3 kinase has been explored as a viable therapy. However, these agents are found to be less than optimal for the treatment of AML because of lack of sufficient potency or suboptimal oral p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d07278cca9360272f2bfbb8f901e2b1
https://doi.org/10.1021/jm9007533
https://doi.org/10.1021/jm9007533
Autor:
Brian T. Campbell, Arup K. Ghose, Helen Hua, Ronald R. Nepomuceno, Joyce James, Mark A. Ator, Brian Struss, Torsten Herbertz, Ruwanthi N. Gunawardane, Mark W. Holladay, Michael Williams, Darren E. Insko, Eduardo Setti, Susan Jones-Bolin, Ianina Valenta, Julius L. Apuy, Sunny Abraham, Martin W. Rowbottom, Michael F. Gardner, Robert C. Armstrong, Merryl D. Cramer, Michael Gibney, Lan Tran, Kelly G. Sprankle, Maiko Ezawa, Bruce D. Dorsey, Raffaella Faraoni, Dana Gitnick, Shripad Bhagwat, Qi Chao, Andiliy G. Lai, Bruce Ruggeri
Publikováno v:
Journal of medicinal chemistry. 55(3)
The Ras/RAF/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathway plays a central role in the regulation of cell growth, differentiation, and survival. Expression of mutant BRAF(V600E) results in constitutive activation of the MAPK pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b9a154f5ee6c6a53767b6f49b9b014
https://pubmed.ncbi.nlm.nih.gov/22168626
https://pubmed.ncbi.nlm.nih.gov/22168626
Autor:
Michael Williams, Kelly G. Sprankle, Mark W. Holladay, Shripad Bhagwat, Qi Chao, Raffaella Faraoni, Dana Gitnick, Lan Tran, Joyce James, Sunny Abraham, Andiliy G. Lai, Brian T. Campbell, Martin W. Rowbottom, Ruwanthi N. Gunawardane, Bruce R. Ruggeri, Michael F. Gardner, Robert C. Armstrong, Mark A. Ator, Bruce D. Dorsey, Eduardo Setti, Merryl D. Cramer
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ce7e41c9edb64b7e28a4e6f99bd14a
https://pubmed.ncbi.nlm.nih.gov/21807507
https://pubmed.ncbi.nlm.nih.gov/21807507
Autor:
Qi, Chao, Kelly G, Sprankle, Robert M, Grotzfeld, Andiliy G, Lai, Todd A, Carter, Anne Marie, Velasco, Ruwanthi N, Gunawardane, Merryl D, Cramer, Michael F, Gardner, Joyce, James, Patrick P, Zarrinkar, Hitesh K, Patel, Shripad S, Bhagwat
Publikováno v:
Journal of medicinal chemistry. 52(23)
Treatment of AML patients with small molecule inhibitors of FLT3 kinase has been explored as a viable therapy. However, these agents are found to be less than optimal for the treatment of AML because of lack of sufficient potency or suboptimal oral p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b50b3db1bf4749a86da8e8c12622655
https://pubmed.ncbi.nlm.nih.gov/19754199
https://pubmed.ncbi.nlm.nih.gov/19754199