Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Merry-Lynn N. McDonald"'
Autor:
Joe W. Chiles III, Ava C. Wilson, Rachel Tindal, Kaleen Lavin, Samuel Windham, Harry B. Rossiter, Richard Casaburi, Anna Thalacker‐Mercer, Thomas W. Buford, Rakesh Patel, J. Michael Wells, Marcas M. Bamman, Beatriz Y. Hanaoka, Mark Dransfield, Merry‐Lynn N. McDonald
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 3, Pp 1016-1029 (2024)
Abstract Background Skeletal muscle dysfunction is a common extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD). Alterations in skeletal muscle myosin heavy chain expression, with reduced type I and increased type II myosin h
Externí odkaz:
https://doaj.org/article/99dd0682e3b04698b9b4d4d0f849e08b
Autor:
Kirsten Voorhies, Kendra Young, Fang-Chi Hsu, Nicholette D. Palmer, Merry-Lynn N. McDonald, Sanghun Lee, Georg Hahn, Julian Hecker, Dmitry Prokopenko, Ann Chen Wu, Elizabeth A. Regan, Dawn DeMeo, Greg L. Kinney, James D. Crapo, Michael H. Cho, Edwin K. Silverman, Christoph Lange, Matthew J. Budoff, John E. Hokanson, Sharon M. Lutz
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 11, Iss 7, p 194 (2024)
Background: Coronary artery calcium (CAC) is a marker of subclinical atherosclerosis and is a complex heritable trait with both genetic and environmental risk factors, including sex and smoking. Methods: We performed genome-wide association (GWA) ana
Externí odkaz:
https://doaj.org/article/0abf222a64e34bfb919a8d586d67f502
Autor:
Ava C. Wilson, Joe Chiles, Shah Ashish, Diptiman Chanda, Preeti L. Kumar, James A. Mobley, Enid R. Neptune, Victor J. Thannickal, Merry-Lynn N. McDonald
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Fibrosis is a leading cause of morbidity and mortality worldwide. Although fibrosis may involve different organ systems, transforming growth factor-β (TGFβ) has been established as a master regulator of fibrosis across organs. Pirfenidone
Externí odkaz:
https://doaj.org/article/9701304c485e469590dc260ebd8077b2
Autor:
Preeti Lakshman Kumar, Ava C. Wilson, Alison Rocco, Michael H. Cho, Emily Wan, Brian D. Hobbs, George R. Washko, Victor E. Ortega, Stephanie A. Christenson, Xingnan Li, J. Michael Wells, Surya P. Bhatt, Dawn L. DeMeo, Sharon M. Lutz, Harry Rossiter, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Wassim W. Labaki, Ruth Tal‐Singer, Russel P. Bowler, Craig P. Hersh, Hemant K. Tiwari, Mark Dransfield, Anna Thalacker‐Mercer, Deborah A. Meyers, Edwin K. Silverman, Merry‐Lynn N. McDonald, COPDGene, ECLIPSE and SPIROMICS investigators
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1803-1817 (2021)
Abstract Background Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. COPD patients with cachexia or weight loss have increased risk of death independent of body mass index (BMI) and lung function. We tested t
Externí odkaz:
https://doaj.org/article/bf76ffb6e2b4400fa7635ccceb291578
Autor:
Zhe Wang, Shing Wan Choi, Nathalie Chami, Eric Boerwinkle, Myriam Fornage, Susan Redline, Joshua C. Bis, Jennifer A. Brody, Bruce M. Psaty, Wonji Kim, Merry-Lynn N. McDonald, Elizabeth A. Regan, Edwin K. Silverman, Ching-Ti Liu, Ramachandran S. Vasan, Rita R. Kalyani, Rasika A. Mathias, Lisa R. Yanek, Donna K. Arnett, Anne E. Justice, Kari E. North, Robert Kaplan, Susan R. Heckbert, Mariza de Andrade, Xiuqing Guo, Leslie A. Lange, Stephen S. Rich, Jerome I. Rotter, Patrick T. Ellinor, Steven A. Lubitz, John Blangero, M. Benjamin Shoemaker, Dawood Darbar, Mark T. Gladwin, Christine M. Albert, Daniel I. Chasman, Rebecca D. Jackson, Charles Kooperberg, Alexander P. Reiner, Paul F. O’Reilly, Ruth J. F. Loos
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Polygenic risk scores (PRSs) aggregate the effects of genetic variants across the genome and are used to predict risk of complex diseases, such as obesity. Current PRSs only include common variants (minor allele frequency (MAF) ≥1%), whereas the co
Externí odkaz:
https://doaj.org/article/de45b04570754641bfdd84ce9401d02c
Autor:
Silva Kasela, Victor E. Ortega, Molly Martorella, Suresh Garudadri, Jenna Nguyen, Elizabeth Ampleford, Anu Pasanen, Srilaxmi Nerella, Kristina L. Buschur, Igor Z. Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Russell P. Bowler, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Gerard J. Criner, Jeffrey L. Curtis, MeiLan K. Han, Nadia N. Hansel, Eric A. Hoffman, Robert J. Kaner, Jerry A. Krishnan, Fernando J. Martinez, Merry-Lynn N. McDonald, Deborah A. Meyers, Robert Paine, Stephen P. Peters, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John V. Fahy, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, Xingnan Li, Wendy C. Moore, Sally E. Wenzel, Joe Zein, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Charles Langelier, Prescott G. Woodruff, Tuuli Lappalainen, Stephanie A. Christenson
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background The large airway epithelial barrier provides one of the first lines of defense against respiratory viruses, including SARS-CoV-2 that causes COVID-19. Substantial inter-individual variability in individual disease courses is hypot
Externí odkaz:
https://doaj.org/article/87ab72a86e144f1c976576cc59d3efd7
Autor:
Ava C. Wilson, Preeti L. Kumar, Sool Lee, Margaret M. Parker, Itika Arora, Jarrett D. Morrow, Emiel F. M. Wouters, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Alvar Agusti, Ruth Tal-Singer, Mark T. Dransfield, J. Michael Wells, Surya P. Bhatt, George Washko, Victor J. Thannickal, Hemant K. Tiwari, Craig P. Hersh, Peter J. Castaldi, Edwin K. Silverman, Merry-Lynn N. McDonald
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Introduction Cachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify differential gene ex
Externí odkaz:
https://doaj.org/article/8fe83349e7e14355b35989dbedb0784d
Autor:
Merry-Lynn N. McDonald, Emiel F. M. Wouters, Erica Rutten, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Marcas Bamman, Bartolome Celli, Alvar Agusti, Ruth Tal-Singer, Craig P. Hersh, Mark Dransfield, Edwin K. Silverman
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Cachexia is associated with increased mortality risk among chronic obstructive pulmonary disease (COPD) patients. However, low body mass index (BMI) as opposed to cachexia is often used, particularly when calculating the BODE (BMI
Externí odkaz:
https://doaj.org/article/1c85ba11211d49cea84cde762645e8ec
Autor:
Kaleen M. Lavin, Yongchao Ge, Stuart C. Sealfon, Venugopalan D. Nair, Katarzyna Wilk, Jeremy S. McAdam, Samuel T. Windham, Preeti Lakshman Kumar, Merry-Lynn N. McDonald, Marcas M. Bamman
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Parkinson’s disease (PD) is the most common motor neurodegenerative disease, and neuromuscular function deficits associated with PD contribute to disability. Targeting these symptoms, our laboratory has previously evaluated 16-week high-intensity r
Externí odkaz:
https://doaj.org/article/7e10fa3bb8e5477faab9386fb5c19532
Autor:
Merry-Lynn N. McDonald, Preeti Lakshman Kumar, Vinodh Srinivasasainagendra, Ashwathy Nair, Alison P. Rocco, Ava C. Wilson, Joe W. Chiles, Joshua S. Richman, Sarah A. Pinson, Richard A. Dennis, Vivek Jagadale, Cynthia J. Brown, Saiju Pyarajan, Hemant K. Tiwari, Marcas M. Bamman, Jasvinder A. Singh
Publikováno v:
Nature Genetics. 54:1816-1826