Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Merry Jo Oursler"'
Autor:
Megan M. Weivoda, Chee Kian Chew, David G. Monroe, Joshua N. Farr, Elizabeth J. Atkinson, Jennifer R. Geske, Brittany Eckhardt, Brianne Thicke, Ming Ruan, Amanda J. Tweed, Louise K. McCready, Robert A. Rizza, Aleksey Matveyenko, Moustapha Kassem, Thomas Levin Andersen, Adrian Vella, Matthew T. Drake, Bart L. Clarke, Merry Jo Oursler, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy s
Externí odkaz:
https://doaj.org/article/801d47b97fd94e109d4d6b51b08d8de3
Autor:
Gongsheng Yuan, Shuting Yang, Andrew Ng, Chuanyun Fu, Merry Jo Oursler, Lianping Xing, Shuying Yang
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101172- (2020)
Summary: Rheumatoid arthritis (RA) is the most common inflammatory disease, which currently lacks effective treatment. Here, we discovered that the Regulator of G Protein Signaling 12 (RGS12) plays a key role in regulating inflammation. Transcription
Externí odkaz:
https://doaj.org/article/4a5830d2ce714f8eb0de51b614da0fb7
Autor:
Andrew Ying Hui Ng, Ziqing Li, Megan M Jones, Shuting Yang, Chunyi Li, Chuanyun Fu, Chengjian Tu, Merry Jo Oursler, Jun Qu, Shuying Yang
Publikováno v:
eLife, Vol 8 (2019)
Regulators of G-protein Signaling are a conserved family of proteins required in various biological processes including cell differentiation. We previously demonstrated that Rgs12 is essential for osteoclast differentiation and its deletion in vivo p
Externí odkaz:
https://doaj.org/article/ebacf9da185844bbaac5f0282d71be3b
Autor:
John R Hawse, Muzaffer Cicek, Sarah B Grygo, Elizabeth S Bruinsma, Nalini M Rajamannan, Andre J van Wijnen, Jane B Lian, Gary S Stein, Merry Jo Oursler, Malayannan Subramaniam, Thomas C Spelsberg
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19429 (2011)
Deletion of TIEG1/KLF10 in mice results in a gender specific osteopenic skeletal phenotype with significant defects in both cortical and trabecular bone, which are observed only in female animals. Calvarial osteoblasts isolated from TIEG1 knockout (K
Externí odkaz:
https://doaj.org/article/c3b2d29944cd4ce390182c32fdb11d6f
Autor:
Muzaffer Cicek, Anne Vrabel, Catherine Sturchio, Larry Pederson, John R Hawse, Malayannan Subramaniam, Thomas C Spelsberg, Merry Jo Oursler
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17522 (2011)
TGF-β Inducible Early Gene-1 (TIEG1) is a Krüppel-like transcription factor (KLF10) that was originally cloned from human osteoblasts as an early response gene to TGF-β treatment. As reported previously, TIEG1(-/-) mice have decreased cortical bon
Externí odkaz:
https://doaj.org/article/08f87d151b71472e8234f49a058e9ead
Autor:
Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Brittany Eckhardt, Stephanie Vos, Sarah Grain, Kveta Kroupova, Ming Ruan, Megan Weivoda, Merry Jo Oursler, Joshua N. Farr, David G. Monroe, Sundeep Khosla
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 37(9)
Estrogen is known to regulate bone metabolism in both women and men, but substantial gaps remain in our knowledge of estrogen and estrogen receptor alpha (ERα) regulation of adult bone metabolism. Studies using global ERα-knockout mice were confoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a1ca971724306a9305746f3ce92bc7
https://pubmed.ncbi.nlm.nih.gov/35789113
https://pubmed.ncbi.nlm.nih.gov/35789113
Autor:
Vishwa Deepak, Shu-ting Yang, Ziqing Li, Xinhua Li, Andrew Ng, Ding Xu, Yi-Ping Li, Merry Jo Oursler, Shuying Yang
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Excess bone loss due to increased osteoclastogenesis is a significant clinical problem. Intraflagellar transport (IFT) proteins have been reported to regulate cell growth and differentiation. The role of IFT80, an IFT complex B protein, in osteoclast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4255359aae6ab63d572e16ed0eccb1
https://doi.org/10.1073/pnas.2201490119
https://doi.org/10.1073/pnas.2201490119
Autor:
Elizabeth W. Bradley, Anna M. Mattson, Merry Jo Oursler, David H. H. Molstad, Jennifer J. Westendorf, Margaret A. Meyer, Dana L. Begun
Publikováno v:
J Biol Chem
Enhanced osteoclast-mediated bone resorption and diminished formation may promote bone loss. Pleckstrin homology (PH) domain and leucine-rich repeat protein phosphatase 1 (Phlpp1) regulates protein kinase C (PKC) and other proteins in the control of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b640fb07aca8fca566aa8049f38cda4
https://doi.org/10.1074/jbc.ra119.007660
https://doi.org/10.1074/jbc.ra119.007660
Autor:
Yi-Ping Li, Shuting Yang, Ziqing Li, Merry Jo Oursler, Alyssa Gilmore, Claire H. Mitchell, Shuying Yang, Tongjun Liu, Chuanyun Fu, Nestor Mas Gomez, Jormay Lim
Publikováno v:
Journal of Bone and Mineral Research. 34:752-764
Bone homeostasis intimately relies on the balance between osteoblasts (OBs) and osteoclasts (OCs). Our previous studies have revealed that regulator of G protein signaling protein 12 (Rgs12), the largest protein in the Rgs super family, is essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d56af66a05eee4fcb2ae0395672c3fa0
https://doi.org/10.1002/jbmr.3645
https://doi.org/10.1002/jbmr.3645
Autor:
Andrew Ng, Lianping Xing, Shuting Yang, Shuying Yang, Gongsheng Yuan, Merry Jo Oursler, Chuanyun Fu
Publikováno v:
iScience
iScience, Vol 23, Iss 6, Pp 101172-(2020)
iScience, Vol 23, Iss 6, Pp 101172-(2020)
Summary Rheumatoid arthritis (RA) is the most common inflammatory disease, which currently lacks effective treatment. Here, we discovered that the Regulator of G Protein Signaling 12 (RGS12) plays a key role in regulating inflammation. Transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac472265774790dcf7cdca93610cd9b
http://europepmc.org/articles/PMC7281782
http://europepmc.org/articles/PMC7281782