Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells

Autor: Jia Tong Loh, Thomas Jun Feng Lim, Kyoko Ikumi, Takuma Matoba, Baptiste Janela, Merry Gunawan, Tatsuya Toyama, Maegan Bunjamin, Lai Guan Ng, Michael Poidinger, Akimichi Morita, Florent Ginhoux, Sayuri Yamazaki, Kong-Peng Lam, I-hsin Su

Publikováno v: iScience, Vol 10, Iss , Pp 23-39 (2018)

Summary: Ezh2, a well-established epigenetic repressor, can down-regulate leukocyte inflammatory responses, but its role in cutaneous health remains elusive. Here we demonstrate that Ezh2 controls cutaneous tolerance by regulating Langerhans cell (LC

Externí odkaz: https://doaj.org/article/20cb73c3b3dc42908530f65184e738a4

The Role of Autophagy in Chemical Proteasome Inhibition Model of Retinal Degeneration

Autor: Choonbing Low, Kurt Neo, Anita Sookyee Chan, Veluchamy A Barathi, Merry Gunawan, Masaaki Kageyama, Candice Ho, Najam A. Sharif, Siawey Yeo

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7271, p 7271 (2021)
Volume 22
Issue 14

We recently demonstrated that chemical proteasome inhibition induced inner retinal degeneration, supporting the pivotal roles of the ubiquitin–proteasome system in retinal structural integrity maintenance. In this study, using beclin1-heterozygous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fabb100327d5edf4e9fe6706e498736
http://europepmc.org/articles/PMC8303873

Donor monocyte–derived macrophages promote human acute graft-versus-host disease

Autor: A. J. Simpson, Gary Reynolds, Xiao-Nong Wang, Sarah Pagan, Laura Jardine, Graham H. Jackson, Urszula Cytlak, Smeera Nair, Merry Gunawan, Matthew Collin, Anna Long, Kile Green, Erin Hurst, Amy Publicover, Christopher A. Lamb, Muzlifah Haniffa, Venetia Bigley, Maharani Paramitha

Publikováno v: Jardine, L, Cytlak, U, Gunawan, M, Reynolds, G, Green, K, Wang, X-N, Pagan, S, Paramitha, M, Lamb, C A, Long, A K, Hurst, E, Nair, S, Jackson, G H, Publicover, A, Bigley, V, Haniffa, M, Simpson, A J & Collin, M 2020, ' Donor monocyte–derived macrophages promote human acute graft-versus-host disease ', Journal of Clinical Investigation, pp. 4574-4586 . https://doi.org/10.1172/JCI133909
The Journal of Clinical Investigation

Myelopoiesis is invariably present and contributes to pathology in animal models of graft-versus-host disease (GVHD). In humans, a rich inflammatory infiltrate bearing macrophage markers has also been described in histological studies. In order to de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b8ae9539dc73a2de539c4782b629e9
https://doi.org/10.1172/JCI133909

Bat-mouse bone marrow chimera: a novel animal model for dissecting the uniqueness of the bat immune system

Autor: Xue Ying Chan, Merry Gunawan, Min Liu, Kylie Su Mei Yong, Randy Foo, Justin H. J. Ng, Sergio Erdal Irac, Lin-Fa Wang, Charles-Antoine Dutertre, Wilson Wei Sheng Tan, Ian H. Mendenhall, Ying Ying Hey, Qingfeng Chen, Yok Teng Chionh, Dolyce H. W. Low, Zhisheng Her, Sue Yee Tan

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)

Bats are an important animal model with long lifespans, low incidences of tumorigenesis and an ability to asymptomatically harbour pathogens. Currently, in vivo studies of bats are hampered due to their low reproduction rates. To overcome this, we tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f372e424e53bbef2a5e7b659d11c621
http://europepmc.org/articles/PMC5856848

Mapping the human DC lineage through the integration of high-dimensional techniques

Autor: Kaibo Duan, Qingfeng Chen, Evan W. Newell, Marc Beyer, Francesca Zolezzi, Muzlifah Haniffa, Patrick Günther, Charles-Antoine Dutertre, Tony Kiat Hon Lim, Nicolas Ruffin, Mabel Jouve, Jinmiao Chen, Andreas Schlitzer, Ester Gea-Mallorquí, Charlene Foong Shu Fen, Sergio Erdal Irac, Peter See, Raoul C.M. Hennekam, Nurhidaya Binte Shadan, Josephine Lum, Joachim L. Schultze, Philippe Benaroch, Ming Wen, Merry Gunawan, Laurent Rénia, Florent Ginhoux, Chan Chung Yip, Kristian Händler, Ivy Low, Hermi Sumatoh, Michael Poidinger, Jerry Kok Yen Chan, Anis Larbi, Benoit Malleret, Alicia Tay, Naomi McGovern

Publikováno v: BASE-Bielefeld Academic Search Engine
Science
Science / Science now 356(6342), eaag3009 (2017). doi:10.1126/science.aag3009
Science, 356(6342), 1044-+. American Association for the Advancement of Science

INTRODUCTION Dendritic cells (DC) are professional antigen-presenting cells that orchestrate immune responses. The human DC population comprises multiple subsets, including plasmacytoid DC (pDC) and two functionally specialized lineages of convention

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81b5fb328e0b4ae88201d4338ec4807
https://doi.org/10.1126/science.aag3009