Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Merritt Maduke"'
Autor:
Mengyuan Xu, Torben Neelands, Alexander S Powers, Yan Liu, Steven D Miller, Grigore D Pintilie, J Du Bois, Ron O Dror, Wah Chiu, Merritt Maduke
Publikováno v:
eLife, Vol 12 (2024)
CLC-2 is a voltage-gated chloride channel that contributes to electrical excitability and ion homeostasis in many different tissues. Among the nine mammalian CLC homologs, CLC-2 is uniquely activated by hyperpolarization, rather than depolarization,
Externí odkaz:
https://doaj.org/article/ff8936247b544286b1d7a57aab5b1a3c
Autor:
Tanmay S Chavan, Ricky C Cheng, Tao Jiang, Irimpan I Mathews, Richard A Stein, Antoine Koehl, Hassane S Mchaourab, Emad Tajkhorshid, Merritt Maduke
Publikováno v:
eLife, Vol 9 (2020)
Among coupled exchangers, CLCs uniquely catalyze the exchange of oppositely charged ions (Cl– for H+). Transport-cycle models to describe and explain this unusual mechanism have been proposed based on known CLC structures. While the proposed models
Externí odkaz:
https://doaj.org/article/b749e602edbc4f7ab3d6e58d1b99d2b3
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 3, p e1007530 (2020)
This work reports a dynamical Markov state model of CLC-2 "fast" (pore) gating, based on 600 microseconds of molecular dynamics (MD) simulation. In the starting conformation of our CLC-2 model, both outer and inner channel gates are closed. The first
Externí odkaz:
https://doaj.org/article/08fcf7558bfb4ff5b38844dd1262fdfc
Autor:
Chandra M Khantwal, Sherwin J Abraham, Wei Han, Tao Jiang, Tanmay S Chavan, Ricky C Cheng, Shelley M Elvington, Corey W Liu, Irimpan I Mathews, Richard A Stein, Hassane S Mchaourab, Emad Tajkhorshid, Merritt Maduke
Publikováno v:
eLife, Vol 5 (2016)
CLC secondary active transporters exchange Cl- for H+. Crystal structures have suggested that the conformational change from occluded to outward-facing states is unusually simple, involving only the rotation of a conserved glutamate (Gluex) upon its
Externí odkaz:
https://doaj.org/article/412dc066a96c480c9b531c04b7b4fecb
Autor:
Gilbert Q Martinez, Merritt Maduke
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2746 (2008)
BACKGROUND: ClC-Kb and ClC-Ka are homologous chloride channels that facilitate chloride homeostasis in the kidney and inner ear. Disruption of ClC-Kb leads to Bartter's Syndrome, a kidney disease. A point mutation in ClC-Kb, R538P, linked to Bartter'
Externí odkaz:
https://doaj.org/article/9a6468fa257c44a48525c0f0b7555939
Autor:
Keri A. McKiernan, J. Du Bois, Yuri A. Kuryshev, Austin L. Reese, John R. Huguenard, Merritt Maduke, Xianlan Wen, Caiyun Wu, Anna K. Koster, Erin E. Gray
Publikováno v:
Proc Natl Acad Sci U S A
CLC-2 is a voltage-gated chloride channel that is widely expressed in many mammalian tissues. In the central nervous system (CNS), CLC-2 is expressed in neurons and glia. Studies to define how this channel contributes to normal and pathophysiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f76bda7caae528ac1e2742ad4cab3c
https://doi.org/10.1073/pnas.2009977117
https://doi.org/10.1073/pnas.2009977117