Výsledky vyhledávání - "Merrill R. Osheroff"

Pharmacokinetics of MMB4 DMS in Rats, Rabbits, and Dogs Following a Single IV Administration

Autor: Jerry D. Johnson, S. Peter Hong, Merrill R. Osheroff, Dean J. Kobs, Seth Gibbs, Brian L. Burback

Publikováno v: International Journal of Toxicology. 32:30S-37S

Organophosphorus (OP) nerve agents pose tremendous threats to both military and civilian populations. The substance 1,1′-methylenebis[4-[(hydroxyimino)methyl]-pyridinium] (MMB4) is being developed as a replacement for the currently fielded 2-pyridi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77347e7b9a10b93a550f31ddd616f914
https://doi.org/10.1177/1091581813488954

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Efficacy and Pharmacokinetic/Pharmacodynamic Study of 1,1′-Methylenebis{4-[(hydroxyimino)methyl] pyridinium} Dimethanesulfonate in Guinea Pigs and Rhesus Macaques Exposed to Cyclosarin

Autor: Jill A. Harvilchuck, Jerry D. Johnson, Jamie S. Richey, Merrill R. Osheroff, S. Peter Hong

Publikováno v: International Journal of Toxicology. 32:108S-117S

Male Hartley guinea pigs and male rhesus macaques were used to determine an efficacious dose of 1,1′-methylenebis{4-[(hydroxyimino)methyl] pyridinium} dimethanesulfonate (MMB4 DMS) that would result in 80% survival, 24 hours following a single expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0f015dff43e7d49184394745e2a1ff
https://doi.org/10.1177/1091581813498425

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Nonclinical Safety Assessment of Intravenous Optison®: A Perfluoropropane (PFP)-Filled Albumin Microspheres Contrast Agent for Ultrasonography

Autor: Yigal Greener, Stephen T. Cornell, Anne L. Killam, Suzanne T. Wolford, Merrill R. Osheroff

Publikováno v: International Journal of Toxicology. 17:631-662

OPTISON (FS069), an ultrasonic diagnostic contrast agent, is a suspension of perfluoropropane (PFP)-filled album in microspheres of 2.0-4.5 microns average diameter and 5.0-8.O x 108 microspheresl ml. The following non clinical safety assessment stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bed1409a0b069c50c61e2861af95f891
https://doi.org/10.1080/109158198225892

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Comparative toxicology studies in Sprague-Dawley rats, rhesus monkeys, and New Zealand White rabbits to determine a no observed adverse effect level for 1,1'-methylenebis[4-[(hydroxyimino)methyl]-pyridinium] dimethanesulfonate

Autor: Claire R. Croutch, Dean J. Kobs, Matthew Buccellato, Merrill R. Osheroff, Laura E. Elcock, Brian L. Burback, Jerry D. Johnson

Publikováno v: International journal of toxicology. 32

Studies were conducted in Sprague-Dawley rats, New Zealand White (NZW) rabbits, and rhesus monkeys to characterize the toxicity of 1,1′-methylenebis[4-[(hydroxyimino)methyl]-pyridinium] dimethanesulfonate (MMB4 DMS) following intramuscular administ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b4c2323625215669622784ce8f6fed
https://pubmed.ncbi.nlm.nih.gov/23929451

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In vivo acetylcholinesterase reactivation in male guinea pigs and rhesus macaques following cyclosarin exposure and treatment with 1,1'-methylenebis{4-[(hydroxyimino)methyl] pyridinium} dimethanesulfonate

Autor: Jerry D. Johnson, Jamie S. Richey, Merrill R. Osheroff, Jill A. Harvilchuck, S. Peter Hong

Publikováno v: International journal of toxicology. 32

Acetylcholinesterase (AChE) reactivation studies were conducted in guinea pigs (GPs) and nonhuman primates (NHPs) to determine the 1,1′-methylenebis{4-[(hydroxyimino)methyl] pyridinium} dimethanesulfonate (MMB4 DMS) dose that reactivated at least 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c0ae420d3332d156f20298f1f438d8
https://pubmed.ncbi.nlm.nih.gov/23929454

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MMB4 DMS: cardiovascular and pulmonary effects on dogs and neurobehavioral effects on rats

Autor: Tom Vinci, Merrill R. Osheroff, Craig R. Hassler, Glenn D. Ritchie, David T. Pressburger, Michael A. Hawk, Brian L. Burback, Brian M. Roche

Publikováno v: International journal of toxicology. 32

The objectives of these studies were to determine the cardiopulmonary effects of a single intramuscular administration of 1,1′-methylenebis[4-[(hydroxyimino)methyl]-pyridinium] dimethanesulfonate (MMB4 DMS) on dogs and on the central nervous system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750755725de62ef43d2669d92676ef21
https://pubmed.ncbi.nlm.nih.gov/23929450

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Comparative toxicokinetics of MMB4 DMS in rats, rabbits, dogs, and monkeys following single and repeated intramuscular administration

Autor: Seth Gibbs, Merrill R. Osheroff, Brian L. Burback, Dean J. Kobs, Claire R. Croutch, Michael A. Hawk, Jerry D. Johnson, S. Peter Hong

Publikováno v: International journal of toxicology. 32

1,1′-Methylenebis[4-[(hydroxyimino)methyl]-pyridinium] (MMB4) dimethanesulfonate (DMS) is a bisquaternary pyridinium aldoxime that reactivates acetylcholinesterase inhibited by organophosphorus nerve agent. Time courses of MMB4 concentrations in pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bda83c39817b4cf2c371fa9a0fbb007
https://pubmed.ncbi.nlm.nih.gov/23929448

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Toxicology and carcinogenesis studies of dietary titanium dioxide-coated mica in male and female Fischer 344 rats

Autor: John H. Mennear, Bruce K. Bernard, Merrill R. Osheroff, Andreas Hofmann

Publikováno v: Journal of toxicology and environmental health. 29(4)

Male and female Fischer 344 rats were fed diets containing 0, 1.0, 2.0, or 5.0% titanium dioxide (TiO2) coated mica for up to 130 wk. This dosage regimen produced no consistent or biologically important changes in survival, body weight gains, hematol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd239756207d257151a0b11c9a840846
https://pubmed.ncbi.nlm.nih.gov/2325155

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