Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Merrick G. Ekins"'
Autor:
Kelsey S. Ramage, Aaron Lock, Jonathan M. White, Merrick G. Ekins, Milton J. Kiefel, Vicky M. Avery, Rohan A. Davis
Publikováno v:
Marine Drugs, Vol 22, Iss 1, p 33 (2024)
The known oxygenated polyhalogenated diphenyl ether, 2-(2′,4′-dibromophenoxy)-3,5-dibromophenol (1), with previously reported activity in multiple cytotoxicity assays was isolated from the sponge Lamellodysidea sp. and proved to be an amenable sc
Externí odkaz:
https://doaj.org/article/b542577dbc8c4ff787036ada173fd849
Autor:
Dale W. Prebble, Safak Er, Mingming Xu, Irena Hlushchuk, Andrii Domanskyi, Mikko Airavaara, Merrick G. Ekins, George D. Mellick, Anthony R. Carroll
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100472- (2022)
The neuronal protein α-synuclein (α-syn) is one of the main constituents of intracellular amyloid aggregations found in the post-mortem brains of Parkinson’s disease (PD) patients. Recently, we screened the MeOH extracts obtained from 300 sub-tro
Externí odkaz:
https://doaj.org/article/ebdbe234d624481a967c223a4a7ebfda
Autor:
Dale W. Prebble, Tanja M. Voser, Safak Er, Irena Hlushchuk, Andrii Domanskyi, Mikko Airavaara, Merrick G. Ekins, George D. Mellick, Anthony R. Carroll
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100302- (2022)
During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Clathria (Thalysias) cf. hesperia was identified with α-synuclein binding activity. The bioassay-guided purification of this extract res
Externí odkaz:
https://doaj.org/article/d9b1edf9ef4c4f8cb9d92ed987c40d02
Autor:
Kelsey S. Ramage, Aya C. Taki, Kah Yean Lum, Sasha Hayes, Joseph J. Byrne, Tao Wang, Andreas Hofmann, Merrick G. Ekins, Jonathan M. White, Abdul Jabbar, Rohan A. Davis, Robin B. Gasser
Publikováno v:
Marine Drugs, Vol 19, Iss 12, p 698 (2021)
High-throughput screening of the NatureBank marine extract library (n = 7616) using a phenotypic assay for the parasitic nematode Haemonchus contortus identified an active extract derived from the Australian marine sponge Citronia sp. Bioassay-guided
Externí odkaz:
https://doaj.org/article/e0f9e8a7604a44ed878ad946b9b762cb
Autor:
Aya C. Taki, Joseph J. Byrne, Abdul Jabbar, Kah Yean Lum, Sasha Hayes, Russell S. Addison, Kelsey S. Ramage, Andreas Hofmann, Merrick G. Ekins, Tao Wang, Bill C. H. Chang, Rohan A. Davis, Robin B. Gasser
Publikováno v:
Molecules, Vol 26, Iss 19, p 5846 (2021)
Widespread resistance in parasitic nematodes to most classes of anthelmintic drugs demands the discovery and development of novel compounds with distinct mechanisms of action to complement strategic or integrated parasite control programs. Products f
Externí odkaz:
https://doaj.org/article/3ab82a1dae5441f481e7c1235d4a3dd0
Publikováno v:
European Journal of Taxonomy, Iss 529 (2019)
A new species of Tethya Lamarck, 1815 is described from a depth of 1000 m on the continental slope of the Great Australian Bight (GAB), southern Australia. The GAB slope was explored as part of systematic benthic surveys to understand unexplored comm
Externí odkaz:
https://doaj.org/article/d8f2c11109f9494792307b456bfa29f9
Autor:
H. M. P. Dilrukshi Herath, Sarah Preston, Abdul Jabbar, Jose Garcia-Bustos, Aya C. Taki, Russell S. Addison, Sasha Hayes, Karren D. Beattie, Sean L. McGee, Sheree D. Martin, Merrick G. Ekins, John N. A. Hooper, Bill C. H. Chang, Andreas Hofmann, Rohan A. Davis, Robin B. Gasser
Publikováno v:
Marine Drugs, Vol 17, Iss 11, p 598 (2019)
There is an urgent need to discover and develop new anthelmintics for the treatment of parasitic nematodes of veterinary importance to circumvent challenges linked to drug resistant parasites. Being one of the most diverse natural ecosystems, the mar
Externí odkaz:
https://doaj.org/article/3e28cf7ce12e43adb4bcb94d81ae4d7a
Autor:
Tanja M. Voser, Joshua B. Hayton, Dale W. Prebble, Ju Jin, Gary Grant, Merrick G. Ekins, Anthony R. Carroll
Publikováno v:
Journal of Natural Products. 86:475-481
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::962cc9c145691360f8804eb7194118fd
https://doi.org/10.1021/acs.jnatprod.2c01125
https://doi.org/10.1021/acs.jnatprod.2c01125
Autor:
Sasha Hayes, Aya C. Taki, Kah Yean Lum, Joseph J. Byrne, Jonathan M. White, Merrick G. Ekins, Robin B. Gasser, Rohan A. Davis
Publikováno v:
Journal of Natural Products. 85:1723-1729
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb5f35a92e4981e1f31c47c4bbcebb7
https://doi.org/10.1021/acs.jnatprod.2c00229
https://doi.org/10.1021/acs.jnatprod.2c00229
Autor:
Dale W. Prebble, Safak Er, Irena Hlushchuk, Andrii Domanskyi, Mikko Airavaara, Merrick G. Ekins, George D. Mellick, Anthony R. Carroll
Publikováno v:
Bioorganicmedicinal chemistry letters. 64
Preventing the aggregation of certain amyloid proteins has the potential to slow down the progression of diseases like Alzheimer's, Parkinson's, and type 2 diabetes mellitus. During a high-throughput screen of 300 Australian marine invertebrate extra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55f9bf96889390842c0d3006aeaedc3
https://pubmed.ncbi.nlm.nih.gov/35301136
https://pubmed.ncbi.nlm.nih.gov/35301136