Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Merribeth J. Morin"'
Autor:
Prasun Kundu, Anthony Semesi, Matthijs M. Jore, Merribeth J. Morin, Virginia L. Price, Alice Liang, Jingxing Li, Kazutoyo Miura, Robert W. Sauerwein, C. Richter King, Jean-Philippe Julien
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Malaria protein Pfs48/45 is a promising transmission-blocking antigen targeted by antibodies. Here, the authors determine the structure of its transmission-blocking epitope I, and generate a humanized monoclonal antibody that binds Pfs48/45 with high
Externí odkaz:
https://doaj.org/article/f164d6aeda444b7184cfe6f2d8f3cc0d
Autor:
Maarten Eldering, Anaïs Bompard, Kazutoyo Miura, Will Stone, Isabelle Morlais, Anna Cohuet, Geert-Jan van Gemert, Patrick M. Brock, Sanna R. Rijpma, Marga van de Vegte-Bolmer, Wouter Graumans, Rianne Siebelink-Stoter, Dari F. Da, Carole A. Long, Merribeth J. Morin, Robert W. Sauerwein, Thomas S. Churcher, Teun Bousema
Publikováno v:
Parasites & Vectors, Vol 10, Iss 1, Pp 1-10 (2017)
Abstract Background With the increasing interest in vaccines to interrupt malaria transmission, there is a demand for harmonization of current methods to assess Plasmodium transmission in laboratory settings. Potential vaccine candidates are currentl
Externí odkaz:
https://doaj.org/article/04a1a119a28d46e6b50fa9eaf991961c
Autor:
Isabella A. Quakyi, Edward Essuman, Victoria Majam, Kazutoyo Miura, Ankit Puri, Kazuyo Takeda, Richard A. Skelton, Nitin Verma, Miranda S. Oakley, Godfree Mlambo, Abhai K. Tripathi, Hong Zheng, Merribeth J. Morin, Carole A. Long, Emily Locke, Scott Meredith, Sanjai Kumar
Publikováno v:
Science Translational Medicine. 13
Malaria vaccines that disrupt the Plasmodium life cycle in mosquitoes and reduce parasite transmission in endemic areas are termed transmission-blocking vaccines (TBVs). Despite decades of research, there are only a few Plasmodium falciparum antigens
Autor:
Jordan L. Plieskatt, Thao P. Pham, Shwu-Maan Lee, Bingbing Deng, Carole A. Long, Luwen Zhou, Chia-Kuei Wu, Yimin Wu, Kazutoyo Miura, Merribeth J. Morin, Ababacar Diouf
Publikováno v:
Vaccine. 37:2073-2078
The standard membrane-feeding assay (SMFA) is a functional assay that has been used to inform the development of transmission-blocking vaccines (TBV) against Plasmodium falciparum malaria. For Pfs230, a lead target antigen for TBV development, a few
Autor:
Wendy Painter, Nicola C. J. E. Eraut, Jim A. Bush, Laura J. Szewczyk, Hamzah Malik, Merribeth J. Morin, Wayne Holman, Firas Almazedi, George R. Painter
Publikováno v:
Antimicrobial Agents and Chemotherapy
Molnupiravir (EIDD-2801/MK-4482), the prodrug of the active antiviral ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931), has activity against a number of RNA viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Autor:
Horatiu V. Vinerean, Steven Richter, Douglas Marthaler, Barry Smith, Christine Maclean, Melanie L. Graham, Robert W. Holdcraft, Merribeth J. Morin, Daniel Galbraith, Euan W. Milne, Melissa A. Laramore, Richard D. Hall, John H. Black, James E. Collins, Lawrence S. Gazda, Michelle M. Michalak, Archie Lovatt, Deborah Hoffer
Publikováno v:
Xenotransplantation
Background The use of porcine islets to replace insulin-producing islet β-cells, destroyed during the diabetogenic disease process, presents distinct challenges if this option is to become a therapeutic reality for the treatment of type 1 diabetes.
Autor:
Leanna M. Upton, Thomas S. Churcher, Merribeth J. Morin, Azra C. Ghani, Ellie Sherrard-Smith, Andrew M. Blagborough, Katarzyna A. Sala, Fiona Angrisano, Michael Betancourt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a47d8dcaa42d12ff58f5fdac81d56da
https://doi.org/10.7554/elife.35213.013
https://doi.org/10.7554/elife.35213.013
Autor:
Jessica A, Chichester, Brian J, Green, R Mark, Jones, Yoko, Shoji, Kazutoyo, Miura, Carole A, Long, Cynthia K, Lee, Christian F, Ockenhouse, Merribeth J, Morin, Stephen J, Streatfield, Vidadi, Yusibov
Publikováno v:
Vaccine. 36(39)
Malaria continues to be one of the world's most devastating infectious tropical diseases, and alternative strategies to prevent infection and disease spread are urgently needed. These strategies include the development of effective vaccines, such as
Autor:
Godfree Mlambo, Abhai K. Tripathi, Merribeth J. Morin, Sanjai Kumar, Hong Zheng, Nitin Verma, Miranda S. Oakley, Timothy G. Myers, Emily Locke
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
The Plasmodium life cycle within the mosquito involves the gamete, zygote, motile ookinete, and the oocyst stage that supports sporogony and sporozoite formation. We mapped the P. falciparum transcriptome as the parasite progresses through the oocyst
Autor:
Azra C. Ghani, Merribeth J. Morin, Andrew M. Blagborough, Katarzyna A. Sala, Ellie Sherrard-Smith, Leanna M. Upton, Thomas S. Churcher, Fiona Angrisano, Michael Betancourt
Publikováno v:
eLife, Vol 7 (2018)
Anti-malarial pre-erythrocytic vaccines (PEV) target transmission by inhibiting human infection but are currently partially protective. It has been posited, but never demonstrated, that co-administering transmission-blocking vaccines (TBV) would enha