IDO2 Drives Autoantibody Production and Joint Inflammation in a Preclinical Model of Arthritis by Repressing Runx1 Function in B Cells.

Autor: Peng W; Lankenau Institute for Medical Research, Wynnewood, PA., Merlo LMF; Lankenau Institute for Medical Research, Wynnewood, PA., Grabler S; Lankenau Institute for Medical Research, Wynnewood, PA., Montgomery JD; Lankenau Institute for Medical Research, Wynnewood, PA., Mandik-Nayak L; Lankenau Institute for Medical Research, Wynnewood, PA.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Dec 01; Vol. 213 (11), pp. 1595-1604.

The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism.

Autor: Merlo LMF; Lankenau Institute for Medical Research, Wynnewood, PA., Peng W; Lankenau Institute for Medical Research, Wynnewood, PA., DuHadaway JB; Lankenau Institute for Medical Research, Wynnewood, PA., Montgomery JD; Lankenau Institute for Medical Research, Wynnewood, PA., Prendergast GC; Lankenau Institute for Medical Research, Wynnewood, PA.; Department of Pathology, Anatomy, and Cell Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA; and.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA., Muller AJ; Lankenau Institute for Medical Research, Wynnewood, PA., Mandik-Nayak L; Lankenau Institute for Medical Research, Wynnewood, PA; mandik-nayakl@mlhs.org.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Feb 01; Vol. 208 (3), pp. 571-581. Date of Electronic Publication: 2021 Dec 29.

Application of simultaneous selective pressures slows adaptation.

Autor: Merlo LMF; Lankenau Institute for Medical Research Wynnewood Pennsylvania USA., Sprouffske K; Disease Area Oncology Novartis Institutes for BioMedical Research Basel Switzerland., Howard TC; Department of Pathology and Laboratory Medicine UC Davis Health Sacramento California USA., Gardiner KL; School of Veterinary Medicine University of Pennsylvania Philadelphia Pennsylvania USA., Caulin AF; PEEL Therapeutics, Inc. Salt Lake City Utah USA., Blum SM; Department of Medical Oncology Dana-Farber Cancer Institute Broad Institute at MIT and Harvard Harvard Medical School, and Massachusetts General Hospital Cancer Center Boston Massachusetts USA., Evans P; Department of Biomedical and Health Informatics Children's Hospital of Philadelphia Philadelphia Pennsylvania USA., Bedalov A; Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington USA., Sniegowski PD; Department of Biology University of Pennsylvania Philadelphia Pennsylvania USA., Maley CC; Arizona State University School of Life Sciences Biodesign Institute Tempe Arizona USA.

Publikováno v: Evolutionary applications [Evol Appl] 2020 Aug 15; Vol. 13 (7), pp. 1615-1625. Date of Electronic Publication: 2020 Aug 15 (Print Publication: 2020).

IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.

Autor: Metz R; New Link Genetics Corporation, Ames, IA, USA., Smith C; Lankenau Institute for Medical Research, Wynnewood, PA, USA., DuHadaway JB; Lankenau Institute for Medical Research, Wynnewood, PA, USA., Chandler P; Immunotherapy Center, Georgia Regents University, Augusta, GA, USA., Baban B; Immunotherapy Center, Georgia Regents University, Augusta, GA, USA., Merlo LMF; Lankenau Institute for Medical Research, Wynnewood, PA, USA., Pigott E; Lankenau Institute for Medical Research, Wynnewood, PA, USA., Keough MP; Lankenau Institute for Medical Research, Wynnewood, PA, USA., Rust S; New Link Genetics Corporation, Ames, IA, USA., Mellor AL; Immunotherapy Center, Georgia Regents University, Augusta, GA, USA., Mandik-Nayak L; Lankenau Institute for Medical Research, Wynnewood, PA, USA.; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, USA., Muller AJ; Lankenau Institute for Medical Research, Wynnewood, PA, USA.; Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Prendergast GC; Lankenau Institute for Medical Research, Wynnewood, PA, USA.; Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.; Department of Pathology, Anatomy and Cell Biology, Jefferson Medical School, Thomas Jefferson University, Philadelphia, PA, USA.

Publikováno v: International immunology [Int Immunol] 2019 Mar 05; Vol. 31 (3), pp. 181-182.

IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis.

Autor: Merlo LMF; Lankenau Institute for Medical Research, Wynnewood PA USA., Pigott E; Lankenau Institute for Medical Research, Wynnewood PA USA., DuHadaway JB; Lankenau Institute for Medical Research, Wynnewood PA USA., Grabler S; Lankenau Institute for Medical Research, Wynnewood PA USA., Metz R; New Link Genetics Corporation, Ames IA USA., Prendergast GC; Lankenau Institute for Medical Research, Wynnewood PA USA.; Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia PA USA.; Kimmel Cancer Center, Thomas Jefferson University, Philadelphia PA USA., Mandik-Nayak L; Lankenau Institute for Medical Research, Wynnewood PA USA.; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia PA USA.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Mar 01; Vol. 192 (5), pp. 2082-2090. Date of Electronic Publication: 2014 Jan 31.