Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Merlin Nithya Gnanapragasam"'
Autor:
Kaustav Mukherjee, Li Xue, Antanas Planutis, Merlin Nithya Gnanapragasam, Andrew Chess, James J Bieker
Publikováno v:
eLife, Vol 10 (2021)
Erythroblastic islands are a specialized niche that contain a central macrophage surrounded by erythroid cells at various stages of maturation. However, identifying the precise genetic and transcriptional control mechanisms in the island macrophage r
Externí odkaz:
https://doaj.org/article/114d6be5ad1f4424b421c4eb34c01a2e
Autor:
Raymond Liang, Genís Campreciós, Yan Kou, Kathleen McGrath, Roberta Nowak, Seana Catherman, Carolina L Bigarella, Pauline Rimmelé, Xin Zhang, Merlin Nithya Gnanapragasam, James J Bieker, Dmitri Papatsenko, Avi Ma'ayan, Emery Bresnick, Velia Fowler, James Palis, Saghi Ghaffari
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005526 (2015)
Circulating red blood cells (RBCs) are essential for tissue oxygenation and homeostasis. Defective terminal erythropoiesis contributes to decreased generation of RBCs in many disorders. Specifically, ineffective nuclear expulsion (enucleation) during
Externí odkaz:
https://doaj.org/article/2134fbafa7e7401d87bf26964b801aab
Expression of the β-like globin genes is under strict developmental control, with both direct and indirect inputs responsible for this effect. One of the major players regulating their transition is KLF1/EKLF, where even a two-fold difference in its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f31f7fdab649cd24c6c39ac4f045bfa1
https://doi.org/10.1101/2021.11.22.469597
https://doi.org/10.1101/2021.11.22.469597
Autor:
Antanas Planutis, James J. Bieker, Merlin Nithya Gnanapragasam, Kaustav Mukherjee, Andrew Chess, Li Xue
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Erythroblastic islands are a specialized niche that contain a central macrophage surrounded by erythroid cells at various stages of maturation. However, identifying the precise genetic and transcriptional control mechanisms in the island macrophage r
Author response: EKLF/KLF1 expression defines a unique macrophage subset during mouse erythropoiesis
Autor:
Andrew Chess, Kaustav Mukherjee, Merlin Nithya Gnanapragasam, Antanas Planutis, James J. Bieker, Li Xue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22e3a2eeb755058abb764f2a01c789fa
https://doi.org/10.7554/elife.61070.sa2
https://doi.org/10.7554/elife.61070.sa2
Publikováno v:
Current Opinion in Hematology. 24:183-190
PURPOSE OF REVIEW Transcriptional regulators provide the molecular and biochemical basis for the cell specific properties and characteristics that follow from their central role in establishing tissue-restricted expression. Precise and sequential con
Autor:
Seana C. Catherman, Kathleen E. McGrath, Merlin Nithya Gnanapragasam, Li Xue, James J. Bieker, James Palis
Publikováno v:
Blood. 128:1631-1641
The mechanisms regulating the sequential steps of terminal erythroid differentiation remain largely undefined, yet are relevant to human anemias that are characterized by ineffective red cell production. Erythroid Kruppel-like Factor (EKLF/KLF1) is a
Autor:
Merlin Nithya Gnanapragasam, Rona Singer Weinberg, John D. Crispino, James J. Bieker, Azra Raza, Ronald Hoffman, Abdullah Mahmood Ali
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Erythroid Krüppel-like Factor (EKLF/KLF1) is an erythroid-enriched transcription factor that plays a global role in all aspects of erythropoiesis, including cell cycle control and differentiation. We queried whether its mutation might play a role in
Publikováno v:
Development. 141:2245-2254
The erythroblastic island provides an important nutritional and survival support niche for efficient erythropoietic differentiation. Island integrity is reliant on adhesive interactions between erythroid and macrophage cells. We show that erythroblas
Autor:
Surya V. Seshan, James J. Bieker, Connie M. Westhoff, Merlin Nithya Gnanapragasam, Deepa Manwani, W. Beau Mitchell, Julie Jaffray, Xinhuo Guo
Publikováno v:
Blood Cells, Molecules, and Diseases. 51:71-75
KLF1 is an erythroid specific transcription factor that is involved in erythroid lineage commitment, globin switching and terminal red blood cell maturation. Various mutations of KLF1 have been identified in humans, which have led to both benign and