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pro vyhledávání: '"Merlin Klußmann"'
Publikováno v:
Molecules, Vol 26, Iss 6, p 1591 (2021)
This review summarizes recent developments in conjugation techniques for the synthesis of cell-penetrating peptide (CPP)–drug conjugates targeting cancer cells. We will focus on small organic molecules as well as metal complexes that were used as c
Externí odkaz:
https://doaj.org/article/497aed6745e34ef3a8c5976bc8ec0885
Autor:
Silja Lucia Salscheider, Sarah Gerlich, Alfredo Cabrera‐Orefice, Esra Peker, Robin Alexander Rothemann, Lena Maria Murschall, Yannik Finger, Karolina Szczepanowska, Zeinab Alsadat Ahmadi, Sergio Guerrero‐Castillo, Alican Erdogan, Mark Becker, Muna Ali, Markus Habich, Carmelina Petrungaro, Nele Burdina, Guenter Schwarz, Merlin Klußmann, Ines Neundorf, David A Stroud, Michael T Ryan, Aleksandra Trifunovic, Ulrich Brandt, Jan Riemer
Publikováno v:
EMBO Journal, 41, 17
EMBO Journal, 41
EMBO Journal, 41
The mitochondrial intermembrane space protein AIFM1 has been reported to mediate the import of MIA40/CHCHD4, which forms the import receptor in the mitochondrial disulfide relay. Here, we demonstrate that AIFM1 and MIA40/CHCHD4 cooperate beyond this
Publikováno v:
Nanoscale Advances. 2:453-462
The capability of cell-penetrating peptides (CPPs) to enable translocation of cargos across biological barriers shows promising pharmaceutical potential for the transport of drug molecules, as well as nanomaterials, into cells. Herein, we report on t
Autor:
Ines Neundorf, Takuya Hashimoto, Daisuke Fujiwara, Merlin Klußmann, Ikuhiko Nakase, Kosuke Noguchi, Kenta Morimoto, Tomoka Takatani-Nakase, Ikuo Fujii, Haruka Sumi, Momoko Obuki, Eiji Yuba, Shinya Nakai
Publikováno v:
Molecular pharmaceutics. 18(9)
The antimicrobial protein CAP18 (approximate molecular weight: 18 000), which was first isolated from rabbit granulocytes, comprises a C-terminal fragment that has negatively charged lipopolysaccharide binding activity. In this study, we found that C
Autor:
Ines Neundorf, Joachim Jose, Anna Nickelsen, Merlin Klußmann, Claudia Götz, D. Lindenblatt, V.M. Applegate, Karsten Niefind
Publikováno v:
Journal of medicinal chemistry. 65(2)
CK2α and CK2α' are paralogous catalytic subunits of CK2, which belongs to the eukaryotic protein kinases. CK2 promotes tumorigenesis and the spread of pathogenic viruses like SARS-CoV-2 and is thus an attractive drug target. Efforts to develop sele
Publikováno v:
Molecules, Vol 26, Iss 1591, p 1591 (2021)
Molecules
Molecules
This review summarizes recent developments in conjugation techniques for the synthesis of cell-penetrating peptide (CPP)–drug conjugates targeting cancer cells. We will focus on small organic molecules as well as metal complexes that were used as c