Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Merlijn J P M T Meens"'
Autor:
Ramesh Chennupati, Merlijn J P M T Meens, Vincent Marion, Ben J Janssen, Wouter H Lamers, Jo G R De Mey, S Eleonore Köhler
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102264 (2014)
Argininosuccinate synthetase (ASS) is essential for recycling L-citrulline, the by-product of NO synthase (NOS), to the NOS substrate L-arginine. Here, we assessed whether disturbed arginine resynthesis modulates endothelium-dependent vasodilatation
Externí odkaz:
https://doaj.org/article/84224269fcdb4318b5c33f291ce9fdb4
Autor:
Léon J A Spijkers, Ben J A Janssen, Jelly Nelissen, Merlijn J P M T Meens, Dayanjan Wijesinghe, Charles E Chalfant, Jo G R De Mey, Astrid E Alewijnse, Stephan L M Peters
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29222 (2011)
We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and marked alterations in sphingolipid biology. Pharmacological elevation of ceramide in isolate
Externí odkaz:
https://doaj.org/article/46004c2b269246d28a6a3d335037f686
Autor:
Merlijn J P M T Meens, Matthijs G Compeer, Tilman M Hackeng, Marc A van Zandvoort, Ben J A Janssen, Jo G R De Mey
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10917 (2010)
BACKGROUND: Endothelin-1 (ET-1), a long-acting paracrine mediator, is implicated in cardiovascular diseases but clinical trials with ET-receptor antagonists were not successful in some areas. We tested whether the quasi-irreversible receptor-binding
Externí odkaz:
https://doaj.org/article/362b3f3584494c208b7774510d6e5d4f
Publikováno v:
Swiss Medical Weekly, Vol 142, Iss 1314 (2012)
Atherosclerosis, a progressive disease of medium- and large-sized arteries, constitutes the major cause of death in developed countries, and is becoming increasingly prevalent in developing countries as well. The main consequences of atherosclerosis
Externí odkaz:
https://doaj.org/article/4e7e3c4bf9e14435814cac70f908a884