Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Merlijn Bazuine"'
Autor:
Merlijn Bazuine, Sheelarani Karunanithi, Maeran Uhm, Tingting Xiong, Louise Chang, Alan R. Saltiel, Shian Huey Chiang, Peng Zhao
Publikováno v:
Science signaling. 10(471)
Insulin stimulates glucose uptake through the translocation of the glucose transporter GLUT4 to the plasma membrane. The exocyst complex tethers GLUT4-containing vesicles to the plasma membrane, a process that requires the binding of the G protein (h
Publikováno v:
Endocrinology. 154:3525-3538
Lipocalin 2 (Lcn2) has previously been characterized as an adipokine/cytokine playing a role in glucose and lipid homeostasis. In this study, we investigate the role of Lcn2 in adipose tissue remodeling during high-fat diet (HFD)-induced obesity. We
Autor:
Teresa Liu, Ebe D'Adamo, Anna M. G. Cali, Deepak Narayan, Markus Eszlinger, Melissa Shaw, Romy Kursawe, Arthur Sherman, Bridget Pierpont, Sonia Caprio, Gerald I. Shulman, Samuel W. Cushman, Merlijn Bazuine
Publikováno v:
Diabetes
Diabetes, 59(9), 2288-2296. American Diabetes Association Inc.
Diabetes, 59(9), 2288-2296. American Diabetes Association Inc.
OBJECTIVE We explored whether the distribution of adipose cell size, the estimated total number of adipose cells, and the expression of adipogenic genes in subcutaneous adipose tissue are linked to the phenotype of high visceral and low subcutaneous
Autor:
Jennifer B. DelProposto, Jonathan Mowers, Fiona E. Yull, Jie Zhou, Alan R. Saltiel, Daniel J. Westcott, Merlijn Bazuine, Nicole M. White, Timothy S. Blackwell, Carey N. Lumeng, Shian Huey Chiang, Jing Tyan Ma, Nathan Qi, Lynn M. Geletka
Publikováno v:
Cell. 138(5):961-975
Obesity is associated with chronic low-grade inflammation that negatively impacts insulin sensitivity. Here, we show that high-fat diet can increase NF-kappaB activation in mice, which leads to a sustained elevation in level of IkappaB kinase epsilon
Autor:
Rob C. G. van de Ven, J. Antonie Maassen, Peter J.A. van den Broek, Gerard C.M. van der Zon, Merlijn Bazuine
Publikováno v:
Biochemical pharmacology, 68(1), 105-112. Elsevier Inc.
Recently, it was shown that rottlerin inhibits insulin-stimulated glucose uptake and reduces intracellular adenosine triphosphate (ATP) levels in 3T3-L1 adipocytes, suggesting that these two events are causally linked. However, several other reports
Autor:
Merlijn Bazuine, Françoise Carlotti, Philippe Pognonec, Tuija Kekarainen, J. Antonie Maassen, Jurgen Seppen, Rob C. Hoeben
Publikováno v:
Molecular therapy, 9(2), 209-217. Nature Publishing Group
Obesity is associated with many serious afflictions such as cardiovascular disease, cancer, and diabetes. One of the main cellular systems used to study the underlying physiological and biological processes is the 3T3-L1 preadipocyte differentiation
Autor:
Merlijn Bazuine, J. Antonie Maassen, Remko R. Bosch, Cees J. Tack, Ad R. M. M. Hermus, Paul N. Span, André J. Olthaar, Helga van Rennes, Peter H.G.M. Willems, C.G.J. Sweep
Publikováno v:
Biochemical journal, 384(Part 2), 349-355. Portland Press Ltd.
Biochemical Journal, 384, 349-55
Biochemical Journal, 384, Pt 2, pp. 349-55
Biochemical Journal, 384, 349-55
Biochemical Journal, 384, Pt 2, pp. 349-55
Contains fulltext : 57749.pdf (Publisher’s version ) (Open Access) Members of the PKC (protein kinase C) superfamily play key regulatory roles in glucose transport. How the different PKC isotypes are involved in the regulation of glucose transport
Autor:
Françoise Carlotti, Rob C. Hoeben, Roos Jahangir Tafrechi, J. Antonie Maassen, Merlijn Bazuine
Publikováno v:
Molecular endocrinology (Baltimore, Md.), 18(7), 1697-1707. The Endocrine Society
Prolonged use of glucocorticoids induces pronounced insulin resistance in vivo. In vitro, treatment of 3T3-L1 adipocytes with dexamethasone for 48 h reduces the maximal level of insulin- and stress (arsenite)-induced glucose uptake by approximately 5
Publikováno v:
European Journal of Biochemistry. 270:3891-3903
The protein-modifying agent arsenite stimulates glucose uptake in 3T3-L1 adipocytes. In the current study we have analysed the signalling pathways that contribute to this response. By subcellular fractionation we observed that arsenite, like insulin,
Autor:
Gail Yee, Alice Y.-C. Liu, Tracey McLaughlin, Merlijn Bazuine, Philip S. Tsao, Matilde Arroyo, Arthur Sherman, Samuel W. Cushman, Alper Sonmez, Gerald M. Reaven
Publikováno v:
Diabetes & vascular disease research, 7(4), 311-318. SAGE Publications Ltd
We recently reported that a preponderance of small adipose cells, decreased expression of cell differentiation markers, and enhanced inflammatory activity in human subcutaneous whole adipose tissue were associated with insulin resistance. To test the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cb643557452c03e1e04c16c58101c6
https://europepmc.org/articles/PMC3462589/
https://europepmc.org/articles/PMC3462589/