Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Merle M. Nicolai"'
Autor:
Viktoria K. Wandt, Nicola Winkelbeiner, Kristina Lossow, Johannes F. Kopp, Maria Schwarz, Wiebke Alker, Merle M. Nicolai, Luise Simon, Caroline Dietzel, Barbara Hertel, Gabriele Pohl, Franziska Ebert, Lutz Schomburg, Julia Bornhorst, Hajo Haase, Anna P. Kipp, Tanja Schwerdtle
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102083- (2021)
Trace elements (TEs) are essential for diverse processes maintaining body function and health status. The complex regulation of the TE homeostasis depends among others on age, sex, and nutritional status. If the TE homeostasis is disturbed, negative
Externí odkaz:
https://doaj.org/article/53491caa78094dea953409458899b2b4
Autor:
Airton C. Martins, Priscila Gubert, Jung Li, Tao Ke, Merle M. Nicolai, Alexandre Varão Moura, Julia Bornhorst, Aaron B. Bowman, Michael Aschner
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1396 (2022)
Caenorhabditis elegans (C. elegans) is a nematode present worldwide. The worm shows homology to mammalian systems and expresses approximately 40% of human disease-related genes. Since Dr. Sydney Brenner first proposed C. elegans as an advantageous ex
Externí odkaz:
https://doaj.org/article/48e5bb429ac24afba6a152a2ac0ddb1e
Autor:
Merle M. Nicolai, Marcello Pirritano, Gilles Gasparoni, Michael Aschner, Martin Simon, Julia Bornhorst
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10748 (2022)
Manganese (Mn) is an essential ubiquitous transition metal and, when occupationally or environmentally overexposed, a well-known risk factor for several neurological pathologies. However, the molecular mechanisms underlying Mn-induced neurotoxicity a
Externí odkaz:
https://doaj.org/article/b7973a9bdcac4873b1550e8ca4278df7
Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans
Autor:
Merle M. Nicolai, Ann-Kathrin Weishaupt, Jessica Baesler, Vanessa Brinkmann, Anna Wellenberg, Nicola Winkelbeiner, Anna Gremme, Michael Aschner, Gerhard Fritz, Tanja Schwerdtle, Julia Bornhorst
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 10905 (2021)
Although manganese (Mn) is an essential trace element, overexposure is associated with Mn-induced toxicity and neurological dysfunction. Even though Mn-induced oxidative stress is discussed extensively, neither the underlying mechanisms of the potent
Externí odkaz:
https://doaj.org/article/d3307c0e15894106b547e00213dc8b52
Publikováno v:
Free Radical Biology and Medicine. 162:216-224
The investigation of neurodegenerative and age-related diseases is a highly relevant topic in current research. Especially oxidative stress is thought to be the common underlying mechanism in diseases such as Parkinson's or Alzheimer's disease. The n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b4fb621b1c68688164ecd8d256528d
https://doi.org/10.1016/j.freeradbiomed.2020.10.019
https://doi.org/10.1016/j.freeradbiomed.2020.10.019
Autor:
Karin Tuschl, Priscila Gubert, Somshuvra Mukhopadhyay, Donald R. Smith, Cherish A. Taylor, Julia Bornhorst, Alexandre M Varão, Merle M. Nicolai, Michael Aschner
Publikováno v:
J Nutr
Manganese is an essential metal, but elevated brain Mn concentrations produce a parkinsonian-like movement disorder in adults and fine motor, attentional, cognitive, and intellectual deficits in children. Human Mn neurotoxicity occurs owing to elevat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b0449000aa819a5f510cfd3f4e4f36
https://doi.org/10.1093/jn/nxaa066
https://doi.org/10.1093/jn/nxaa066
Publikováno v:
Archives of Toxicology, 95, 3417–3424
Archives of Toxicology
Archives of Toxicology
The identification of genotoxic agents and their potential for genotoxic alterations in an organism is crucial for risk assessment and approval procedures of the chemical and pharmaceutical industry. Classically, testing strategies for DNA or chromos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2a61cc76bb60341f2250a621a1e1f5
Autor:
Julia Bornhorst, Michael Aschner, Catherine Neumann, Gereon Steffen, Tanja Schwerdtle, Aswin Mangerich, Tabea Zubel, Jessica Baesler, Alexander Bürkle, Merle M. Nicolai
Publikováno v:
J Trace Elem Med Biol
Background and AimWhen exceeding the homeostatic range, manganese (Mn) might cause neurotoxicity, characteristic of the pathophysiology of several neurological diseases. Although the underlying mechanism of its neurotoxicity remains unclear, Mn-induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff84fe163a466984e1d2a62a195ff905
Autor:
Merle M. Nicolai, Gabriele Pohl, Viktoria K. Wandt, Johannes F. Kopp, Maria Luiza Schwarz, Luise Simon, Franziska Ebert, Anna P. Kipp, Kristina Lossow, Hajo Haase, Caroline Dietzel, Tanja Schwerdtle, Lutz Schomburg, Nicola Winkelbeiner, Julia Bornhorst, Wiebke Alker, Barbara Hertel
Publikováno v:
Redox Biology, Vol 46, Iss, Pp 102083-(2021)
Redox Biology
Redox Biology
Trace elements (TEs) are essential for diverse processes maintaining body function and health status. The complex regulation of the TE homeostasis depends among others on age, sex, and nutritional status. If the TE homeostasis is disturbed, negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f68341f20e77fad94b60ff55da7c4b4
https://doi.org/10.1016/j.redox.2021.102083
https://doi.org/10.1016/j.redox.2021.102083
Publikováno v:
Journal of Chromatography A. 1655:462481
Sphingolipids exert important functions in cells, ranging from stabilising the cell membrane to bioactive signalling in signal transduction pathways. Changed concentrations of sphingolipids are associated with, among others, neurodegenerative and car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8aa95e08b55d9e2c2a3a644b3cb4df
https://doi.org/10.1016/j.chroma.2021.462481
https://doi.org/10.1016/j.chroma.2021.462481