Impulsive-compulsive behaviour in early Parkinson’s disease is determined by apathy and dopamine receptor D3 polymorphism

Autor: Hendrik Theis, Stéphane Prange, Gérard N. Bischof, Merle C. Hoenig, Marc Tittgemeyer, Lars Timmermann, Gereon R. Fink, Alexander Drzezga, Carsten Eggers, Thilo van Eimeren

Publikováno v: npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-7 (2023)

Abstract Impulsive-compulsive behaviour (ICB) is a frequently observed non-motor symptom in early Parkinson’s disease after initiating dopamine replacement therapy. At the opposite end of the motivated behaviour spectrum, apathy occurs in early Par

Externí odkaz: https://doaj.org/article/d8b9f2365bfd433eb5435de244ce6a9f

Clear-headed into old age: Resilience and resistance against brain aging-A PET imaging perspective

Autor: Merle C. Hoenig, Alexander Drzezga

Publikováno v: Journal of neurochemistry 164(3), 325-345 (2023). doi:10.1111/jnc.15598

With the advances in modern medicine and the adaptation towards healthier lifestyles, the average life expectancy has doubled since the 1930s, with individuals born in the millennium years now carrying an estimated life expectancy of around 100 years

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440a86534022881daee153a5777d423e
https://pubmed.ncbi.nlm.nih.gov/35226362

Dopamine metabolism of the nucleus accumbens and fronto-striatal connectivity modulate impulse control

Autor: Marc Tittgemeyer, Carsten Eggers, Hendrik Theis, Lars Timmermann, Gereon R. Fink, Merle C Hoenig, Kathrin Giehl, Jochen Hammes, Thilo van Eimeren, Andrea Greuel, Alexander Drzezga

Publikováno v: Brain 142(3), 733-743 (2019). doi:10.1093/brain/awz007

Impulsive-compulsive behaviours like pathological gambling or hypersexuality are a frequent side effect of dopamine replacement therapy in patients with Parkinson's disease. Multiple imaging studies suggest a significant reduction of presynaptic dopa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf05f3010b88b65142759f07f8a39a5
https://doi.org/10.1093/brain/awz007

Level of education mitigates the impact of tau pathology on neuronal function

Autor: Gereon R. Fink, Merle C Hoenig, Gérard N. Bischof, Alzheimer’s Disease Neuroimaging Initiative, Juraj Kukolja, Thilo van Eimeren, Klaus Fliessbach, Elke Kalbe, Özgür A. Onur, Alexander Drzezga, Bernd Neumaier, Frank Jessen

Publikováno v: European journal of nuclear medicine and molecular imaging 46(9), 1787-1795 (2019). doi:10.1007/s00259-019-04342-3
European journal of nuclear medicine and molecular imaging 46(9), 1787–1795 (2019). doi:10.1007/s00259-019-04342-3

PurposeUsing PET imaging in a group of patients with Alzheimer’s disease (AD), we investigated whether level of education, a proxy for resilience, mitigates the harmful impact of tau pathology on neuronal function.MethodsWe included 38 patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b1e95f4414c734f90bcfe921259835
https://pub.dzne.de/record/140809

[18F]-PI-2620 pour le diagnostic de la paralysie supranucléaire progressive : à propos d’un cas

Autor: Alexander Drzezga, Laurent Guillon, Pierre Payoux, J Hammes, Gérard Bischof, T van Eimeren, Merle C Hoenig, B. Neumaie

Publikováno v: Médecine Nucléaire. 44:87

Introduction La paralysie supranucleaire progressive (PSP) est une maladie neurodegenerative rare, avec une accumulation d’isoforme de la proteine tau a quatre motifs repetes (4R). Cette tauopathie est caracterisee par un syndrome parkinsonien atyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0524cfdce4d300fede674857c2c7b21d
https://doi.org/10.1016/j.mednuc.2020.01.089