Pharmacokinetics and pharmacodynamics of a new highly concentrated intranasal midazolam formulation for conscious sedation.

Autor: Schrier L; Centre for Human Drug Research (CHDR), Leiden, The Netherlands., Zuiker R; Centre for Human Drug Research (CHDR), Leiden, The Netherlands., Merkus FW; MEDIR B.V., Doorn, The Netherlands., Klaassen ES; Centre for Human Drug Research (CHDR), Leiden, The Netherlands., Guan Z; Centre for Human Drug Research (CHDR), Leiden, The Netherlands., Tuk B; TCIM B.V., Willemstad, The Netherlands., van Gerven JM; Centre for Human Drug Research (CHDR), Leiden, The Netherlands., van der Geest R; 3D-PharmXchange B.V., Tilburg, The Netherlands., Groeneveld GJ; Centre for Human Drug Research (CHDR), Leiden, The Netherlands.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2017 Apr; Vol. 83 (4), pp. 721-731. Date of Electronic Publication: 2016 Dec 20.

Uptake of fluorescein isothiocyanate-labelled dextran into the CSF after intranasal and intravenous administration to rats.

Autor: in 't Veen JP; Division of Pharmaceutical Technology and Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands., van den Berg MP, Romeijn SG, Verhoef JC, Merkus FW

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2005 Sep; Vol. 61 (1-2), pp. 27-31.

Uptake of melatonin into the cerebrospinal fluid after nasal and intravenous delivery: studies in rats and comparison with a human study.

Autor: van den Berg MP; Division of Pharmaceutical Technology and Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands., Merkus P, Romeijn SG, Verhoef JC, Merkus FW

Publikováno v: Pharmaceutical research [Pharm Res] 2004 May; Vol. 21 (5), pp. 799-802.

Direct access of drugs to the human brain after intranasal drug administration?

Autor: Merkus P; Department of Otorhinolaryngology and Head and Neck Surgery, Academic Medical Center, University of Amsterdam, The Netherlands. P.Merkus@VUmc.nl, Guchelaar HJ, Bosch DA, Merkus FW

Publikováno v: Neurology [Neurology] 2003 May 27; Vol. 60 (10), pp. 1669-71.

Serial cerebrospinal fluid sampling in a rat model to study drug uptake from the nasal cavity.

Autor: van den Berg MP; Department of Pharmaceutical Technology and Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands., Romeijn SG, Verhoef JC, Merkus FW

Publikováno v: Journal of neuroscience methods [J Neurosci Methods] 2002 Apr 30; Vol. 116 (1), pp. 99-107.