Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Merks, Roeland M. H."'
Autor:
van Steijn, Leonie, Wondergem, Joeri A. J., Schakenraad, Koen, Heinrich, Doris, Merks, Roeland M. H.
In vivo, cells navigate through complex environments filled with obstacles. Recently, the term 'topotaxis' has been introduced for navigation along topographic cues such as obstacle density gradients. Experimental and mathematical efforts have analyz
Externí odkaz:
http://arxiv.org/abs/2306.08957
We analyze an 'up-the-gradient' model for the formation of transport channels of the phytohormone auxin, through auxin-mediated polarization of the PIN1 auxin transporter. We show that this model admits a family of travelling wave solutions that is p
Externí odkaz:
http://arxiv.org/abs/2203.02031
Recent experiments on monolayers of spindle-like cells plated on adhesive stripe-shaped domains have provided a convincing demonstration that certain types of collective phenomena in epithelia are well described by active nematic hydrodynamics. While
Externí odkaz:
http://arxiv.org/abs/1909.05856
Autor:
Schakenraad, Koen, Ravazzano, Linda, Sarkar, Niladri, Wondergem, Joeri A. J., Merks, Roeland M. H., Giomi, Luca
Publikováno v:
Phys. Rev. E 101, 032602 (2020)
Recent experimental studies have demonstrated that cellular motion can be directed by topographical gradients, such as those resulting from spatial variations in the features of a micropatterned substrate. This phenomenon, known as topotaxis, is espe
Externí odkaz:
http://arxiv.org/abs/1908.06078
Many animal cells change their shape depending on the stiffness of the substrate on which they are cultured: they assume small, rounded shapes in soft ECMs, they elongate within stiffer ECMs, and flatten out on hard substrates. Cells tend to prefer s
Externí odkaz:
http://arxiv.org/abs/1906.08962
Autor:
Schakenraad, Koen, Ernst, Jeremy, Pomp, Wim, Danen, Erik H. J., Merks, Roeland M. H., Schmidt, Thomas, Giomi, Luca
We investigate the mechanical interplay between the spatial organization of the actin cytoskeleton and the shape of animal cells adhering on micropillar arrays. Using a combination of analytical work, computer simulations and in vitro experiments, we
Externí odkaz:
http://arxiv.org/abs/1905.09805
Cell-based, mathematical modeling of collective cell behavior has become a prominent tool in developmental biology. Cell-based models represent individual cells as single particles or as sets of interconnected particles, and predict the collective ce
Externí odkaz:
http://arxiv.org/abs/1810.12212
Autor:
Szabó, András, Merks, Roeland M. H.
Publikováno v:
PLoS Computational Biology 2017, 13(7): e1005635
Cancer is a disease of cellular regulation, often initiated by genetic mutation within cells, and leading to a heterogeneous cell population within tissues. In the competition for nutrients and growth space within the tumors the phenotype of each cel
Externí odkaz:
http://arxiv.org/abs/1702.06508
Autor:
Pomp, Wim, Schakenraad, Koen, Balcioğlu, Hayri E., van Hoorn, Hedde, Danen, Erik H. J., Merks, Roeland M. H., Schmidt, Thomas, Giomi, Luca
Publikováno v:
Phys. Rev. Lett. 121, 178101 (2018)
We investigate the geometrical and mechanical properties of adherent cells characterized by a highly anisotropic actin cytoskeleton. Using a combination of theoretical work and experiments on micropillar arrays, we demonstrate that the shape of the c
Externí odkaz:
http://arxiv.org/abs/1702.03916
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