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Immune escape of colorectal tumours via local LRH ‐1/Cyp11b1‐mediated synthesis of immunosuppressive glucocorticoids

Autor: Ahmed, Asma, Reinhold, Cindy, Breunig, Eileen, Phan, Truong San, Dietrich, Lea, Kostadinova, Feodora, Urwyler, Corinne, Merk, Verena M, Noti, Mario, Toja da Silva, Israel, Bode, Konstantin, Nahle, Fatima, Plazzo, Anna Pia, Koerner, Julia, Stuber, Regula, Menche, Constantin, Karamitopoulou, Evanthia, Farin, Henner F, Gollob, Kenneth J, Brunner, Thomas

Publikováno v: Molecular Oncology
Ahmed, Asma; Reinhold, Cindy; Breunig, Eileen; Phan, Truong San; Dietrich, Lea; Kostadinova, Feodora; Urwyler, Corinne; Merk, Verena M; Noti, Mario; Toja da Silva, Israel; Bode, Konstantin; Nahle, Fatima; Plazzo, Anna Pia; Koerner, Julia; Stuber, Regula; Menche, Constantin; Karamitopoulou, Evanthia; Farin, Henner F; Gollob, Kenneth J and Brunner, Thomas (2023). Immune escape of colorectal tumors via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids. (In Press). Molecular oncology FEBS Press 10.1002/1878-0261.13414

Control of tumour development and growth by the immune system critically defines patient fate and survival. What regulates the escape of colorectal tumours from destruction by the immune system remains currently unclear. Here, we investigated the rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f71b6752da83e90fc0607f209efb6f
https://doi.org/10.1002/1878-0261.13414

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Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids.

Autor: Phan TS; Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany., Schink L; Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany., Mann J; Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany., Merk VM; Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany., Zwicky P; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Mundt S; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Simon D; Department of Dermatology, Inselspital University Hospital, Bern, Switzerland., Kulms D; Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden, Germany., Abraham S; Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden, Germany., Legler DF; Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland.; Theodor Kocher Institute, University of Bern, Bern, Switzerland., Noti M; Institute of Pathology, University of Bern, Bern, Switzerland., Brunner T; Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany. thomas.brunner@uni-konstanz.de.

Publikováno v: Science advances [Sci Adv] 2021 Jan 29; Vol. 7 (5). Date of Electronic Publication: 2021 Jan 29 (Print Publication: 2021).