Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Merja Niemi"'
Autor:
Juha Rouvinen, Janne Jänis, Marja-Leena Laukkanen, Sirpa Jylhä, Merja Niemi, Tero Päivinen, Soili Mäkinen-Kiljunen, Tari Haahtela, Hans Söderlund, Kristiina Takkinen
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9037 (2010)
BACKGROUND: Allergen-mediated cross-linking of IgE antibodies bound to the FcepsilonRI receptors on the mast cell surface is the key feature of the type I allergy. If an allergen is a homodimer, its allergenicity is enhanced because it would only nee
Externí odkaz:
https://doaj.org/article/bf361d98e4f645daaf31a70b18ba8588
Publikováno v:
Scientific Reports
Haka, J, Niemi, M H, Mattila, P, Jänis, J, Takkinen, K & Rouvinen, J 2019, ' Development of hypoallergenic variants of the major horse allergen Equ c 1 for immunotherapy by rational structure based engineering ', Scientific Reports, vol. 9, no. 1, 20148 . https://doi.org/10.1038/s41598-019-56812-1
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Haka, J, Niemi, M H, Mattila, P, Jänis, J, Takkinen, K & Rouvinen, J 2019, ' Development of hypoallergenic variants of the major horse allergen Equ c 1 for immunotherapy by rational structure based engineering ', Scientific Reports, vol. 9, no. 1, 20148 . https://doi.org/10.1038/s41598-019-56812-1
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
The use of recombinant allergens is a promising approach in allergen-specific immunotherapy (AIT). Considerable limitation, however, has been the ability of recombinant allergens to activate effector cells leading to allergic reactions. Recombinant h
Publikováno v:
Molecular Immunology. 61:7-15
Four out of six officially recognized dog allergens are members of the lipocalin protein family. So far, a three-dimensional structure has been determined for only one dog allergen, Can f 2, which is a lipocalin protein. We present here the crystal s
Autor:
Timo Pulli, Laura Turunen, Matti Höyhtyä, Kristiina Takkinen, Juha Rouvinen, Merja Niemi, Tarja K. Nevanen, Hans Söderlund
Publikováno v:
Niemi, M H, Turunen, L, Pulli, T, Nevanen, T, Höyhtyä, M, Söderlund, H, Rouvinen, J & Takkinen, K 2010, ' A structural insight into the molecular recognition of a (−)-Δ 9-tetrahydrocannabinol and the development of a sensitive, one-step, homogeneous immunocomplex-based assay for its detection ', Journal of Molecular Biology, vol. 400, no. 4, pp. 803-814 . https://doi.org/10.1016/j.jmb.2010.05.048
(−)-Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound found in cannabis. In this study, an anti-THC Fab fragment, designed T3, was isolated from a display library cloned from the spleen cells of a mouse immunized with a THC–bovine
Autor:
Marja-Leena Laukkanen, Johanna Kallio, Nina Hakulinen, Janne Jänis, Kristiina Takkinen, Juha Rouvinen, Merja Niemi, Sirpa Jylhä
Publikováno v:
Niemi, M, Jänis, J, Jylhä, S, Kallio, J M, Hakulinen, N, Laukkanen, M-L, Takkinen, K & Rouvinen, J 2008, ' Characterization and crystallization of a recombinant IgE Fab fragment in complex with the bovine [beta]-lactoglobulin allergen ', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, vol. 64, no. 1, pp. 25-28 . https://doi.org/10.1107/S174430910706160X
A D1 Fab fragment containing the allergen-binding variable domains of the IgE antibody was characterized by ESI FT-ICR mass spectrometry and crystallized with bovine beta-lactoglobulin (BLG) using the hanging-drop vapour-diffusion method at 293 K. X-
Autor:
Nina Hakulinen, Kristiina Takkinen, Hans Söderlund, Johanna Kallio, Soili Mäkinen-Kiljunen, Marja-Leena Laukkanen, Sirpa Jylhä, Merja Niemi, Juha Rouvinen, Tari Haahtela
Publikováno v:
Niemi, M, Jylhä, S, Laukkanen, M-L, Söderlund, H, Mäkinen-Kiljunen, S, Kallio, J M, Hakulinen, N, Haahtela, T, Takkinen, K & Rouvinen, J 2007, ' Molecular interactions between a recombinant IgE antibody and the beta-lactoglobulin allergen ', Structure, vol. 15, no. 11, pp. 1413-1421 . https://doi.org/10.1016/j.str.2007.09.012
Allergies are caused by the immune reaction to commonly harmless proteins, allergens. This reaction is typified by immunoglobulin E (IgE) antibodies. We report the crystal structure of an IgE Fab fragment in complex with β-lactoglobulin (BLG), one o
Autor:
Marja Rytkönen-Nissinen, Janne Jänis, Merja Niemi, Ilja Miettinen, Tuomas Virtanen, Juha Rouvinen
Publikováno v:
Scientific Reports
'Scientific Reports ', vol: 5, pages: 13841-1-13841-13 (2015)
'Scientific Reports ', vol: 5, pages: 13841-1-13841-13 (2015)
Lipocalins are one of the most important groups of inhalant animal allergens. The analysis of structural features of these proteins is important to get insights into their allergenicity. We have determined two different dimeric crystal structures for
Autor:
Kristiina Iljin, Vanga Siva Reddy, Kristiina Takkinen, Merja Niemi, Marja-Leena Laukkanen, Jaana Haka
Publikováno v:
Haka, J, Niemi, M H, Iljin, K, Reddy, V S, Takkinen, K & Laukkanen, M-L 2015, ' Isolation of Mal d 1 and Api g 1-specific recombinant antibodies from mouse IgG Fab fragment libraries : Mal d 1-specific antibody exhibits cross-reactivity against Bet v 1 ', BMC Biotechnology, vol. 15, 34 . https://doi.org/10.1186/s12896-015-0157-5
BMC Biotechnology
BMC Biotechnology
Background: Around 3-5% of the population suffer from IgE-mediated food allergies in Western countries and the number of food-allergenic people is increasing. Individuals with certain pollen allergies may also suffer from a sensitisation to proteins
Autor:
Janne Jänis, Tero Päivinen, Tari Haahtela, Sirpa Jylhä, Juha Rouvinen, Marja-Leena Laukkanen, Kristiina Takkinen, Hans Söderlund, Soili Mäkinen-Kiljunen, Merja Niemi
Publikováno v:
Rouvinen, J, Jänis, J, Laukkanen, M-L, Jylhä, S, Niemi, M, Päivinen, T, Mäkinen-Kiljunen, S, Haahtela, T, Söderlund, H & Takkinen, K 2010, ' Transient dimers of allergens ', PLoS ONE, vol. 5, no. 2, e9037 . https://doi.org/10.1371/journal.pone.0009037
PLoS ONE
PLoS ONE, Vol 5, Iss 2, p e9037 (2010)
PLoS ONE
PLoS ONE, Vol 5, Iss 2, p e9037 (2010)
BackgroundAllergen-mediated cross-linking of IgE antibodies bound to the FcεRI receptors on the mast cell surface is the key feature of the type I allergy. If an allergen is a homodimer, its allergenicity is enhanced because it would only need one t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b8d20822604a866e50a60d97620d1d
https://cris.vtt.fi/en/publications/ba87dfd2-e887-4b57-9175-5e30be4db2f7
https://cris.vtt.fi/en/publications/ba87dfd2-e887-4b57-9175-5e30be4db2f7
Autor:
Martina Andberg, Juha Rouvinen, Janne Jänis, Merja Niemi, Helena Taberman, Anu Koivula, Nina Hakulinen, Tarja Parkkinen
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 69:s306-s307