Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Meritxell Oliva"'
Autor:
Niyati Jain, James L. Li, Lin Tong, Farzana Jasmine, Muhammad G. Kibriya, Kathryn Demanelis, Meritxell Oliva, Lin S. Chen, Brandon L. Pierce
Publikováno v:
Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Background While the association of chronological age with DNA methylation (DNAm) in whole blood has been extensively studied, the tissue-specificity of age-related DNAm changes remains an active area of research. Studies investigating the a
Externí odkaz:
https://doaj.org/article/3769ff580e254d24bd05ac83d2daf568
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Genetic effects on functionally related ‘omic’ traits often co-occur in relevant cellular contexts, such as tissues. Motivated by the multi-tissue methylation quantitative trait loci (mQTLs) and expression QTLs (eQTLs) analysis, we propo
Externí odkaz:
https://doaj.org/article/41e2b8339a3045c7ba98d487b26cd84f
Autor:
Meytal Batya Chernoff, Dayana Delgado, Lin Tong, Lin Chen, Meritxell Oliva, Lizeth I Tamayo, Lyle G Best, Shelley Cole, Farzana Jasmine, Muhammad G Kibriya, Heather Nelson, Lei Huang, Karin Haack, Jack Kent, Jason G Umans, Joseph Graziano, Ana Navas-Acien, Margaret R Karagas, Habib Ahsan, Brandon L Pierce
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010588 (2023)
Inorganic arsenic is highly toxic and carcinogenic to humans. Exposed individuals vary in their ability to metabolize arsenic, and variability in arsenic metabolism efficiency (AME) is associated with risks of arsenic-related toxicities. Inherited ge
Externí odkaz:
https://doaj.org/article/f1d264f7294348ab818c10910f42e6f0
Autor:
Carla Giner-Delgado, Sergi Villatoro, Jon Lerga-Jaso, Magdalena Gayà-Vidal, Meritxell Oliva, David Castellano, Lorena Pantano, Bárbara D. Bitarello, David Izquierdo, Isaac Noguera, Iñigo Olalde, Alejandra Delprat, Antoine Blancher, Carles Lalueza-Fox, Tõnu Esko, Paul F. O’Reilly, Aida M. Andrés, Luca Ferretti, Marta Puig, Mario Cáceres
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Inversions are a little-studied type of genomic variation that could contribute to phenotypic traits. Here the authors characterize 45 common polymorphic inversions in human populations and investigate their evolutionary and functional impact.
Externí odkaz:
https://doaj.org/article/e87af4a6016b4aa1a4674b4e363f305d
Autor:
Miranda D Stobbe, Gian A Thun, Andrea Diéguez-Docampo, Meritxell Oliva, Justin P Whalley, Emanuele Raineri, Ivo G Gut
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 11, p e1007496 (2019)
The sheer size of the human genome makes it improbable that identical somatic mutations at the exact same position are observed in multiple tumours solely by chance. The scarcity of cancer driver mutations also precludes positive selection as the sol
Externí odkaz:
https://doaj.org/article/6eed99736a684118816fba2838116440
Autor:
Cristina Aguado, Magdalena Gayà-Vidal, Sergi Villatoro, Meritxell Oliva, David Izquierdo, Carla Giner-Delgado, Víctor Montalvo, Judit García-González, Alexander Martínez-Fundichely, Laia Capilla, Aurora Ruiz-Herrera, Xavier Estivill, Marta Puig, Mario Cáceres
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004208 (2014)
In recent years different types of structural variants (SVs) have been discovered in the human genome and their functional impact has become increasingly clear. Inversions, however, are poorly characterized and more difficult to study, especially tho
Externí odkaz:
https://doaj.org/article/c063a70f211f473097dde4cbc2d26590
Autor:
Meritxell Oliva, Kathryn Demanelis, Yihao Lu, Meytal Chernoff, Farzana Jasmine, Habibul Ahsan, Muhammad G. Kibriya, Lin S. Chen, Brandon L. Pierce
Publikováno v:
Nat Genet
Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-specific characterization of DNAm is needed to understand its role in gene regulation and its relevance to complex traits. We generated array-based DNAm profiles f
The proliferation of association results from large-scale genetic and genomic studies provides opportunities and challenges to elucidate the disease/trait mechanisms and their operating cellular contexts. Motivated by a multi-tissue multi-omics analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ce8e20ab796dbbfdb3ed90d78fa0f8a
https://doi.org/10.21203/rs.3.rs-2137179/v1
https://doi.org/10.21203/rs.3.rs-2137179/v1
Autor:
Jason Karpus, Sheng Zhang, Chuan He, Marija Dobratic, Mark A. Applebaum, Wei Zhang, Alexandre Chlenski, Erin K. Barr, Emma Wilkinson, Lucy A. Godley, Susan L. Cohn, Barbara E. Stranger, Elizabeth A. Sokol, Robert L. Grossman, Meritxell Oliva, Diana C. West-Szymanski, Helen R. Salwen, Zhou Zhang
Publikováno v:
Clin Cancer Res
Purpose: 5-Hydroxymethylcytosine (5-hmC) is an epigenetic marker of open chromatin and active gene expression. We profiled 5-hmC with Nano-hmC-Seal technology using 10 ng of plasma-derived cell-free DNA (cfDNA) in blood samples from patients with neu
Autor:
Alice Mouton, Matteo Pellegrini, Feiyang Ma, Meritxell Oliva, Keith Mitchell, Benjamin L. Shou, Serghei Mangul, Barbara E. Stranger, Sarah Kim-Hellmuth, Brian B. Nadel, Dennis Montoya
Publikováno v:
Briefings in bioinformatics, vol 22, iss 6
Brief Bioinform
Brief Bioinform
Estimating cell type composition of blood and tissue samples is a biological challenge relevant in both laboratory studies and clinical care. In recent years, a number of computational tools have been developed to estimate cell type abundance using g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be88c8136ab43d5695734bade7dfa0b
https://escholarship.org/uc/item/10s151m1
https://escholarship.org/uc/item/10s151m1