Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Meritxell López-Canet"'
Publikováno v:
The Journal of Organic Chemistry. 67:4945-4950
The first total synthesis of aquatic peptide microcin SF608 is described. Coupling of L-Hpla with the dipeptide L-Phe-L-Choi followed by coupling with agmatine and a deprotection step gave microcin SF608. In addition, the levorotatory character of L-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac757c88342f5f925e96a446c516ad9
https://doi.org/10.1021/jo025709y
https://doi.org/10.1021/jo025709y
Autor:
Silvia Cerezo-Galvez, Meinolf Thiemann, Meritxell López-Canet, Holger Deppe, Sonja Nordhoff, Victor G. Matassa, Oliver Hill, Achim Feurer, Christian Rummey, Paul J. Edwards
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4201-4203
Modifications of DPP-4 inhibitor 5, that was discovered by structure based design, are described and structure–activity relationships discussed. With analogue 7k one of the most potent non-covalent inhibitors of DPP-4 reported to date (IC50 = 0.38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503db82633cf0b4a63302b0983499e80
https://doi.org/10.1016/j.bmcl.2009.05.109
https://doi.org/10.1016/j.bmcl.2009.05.109
Autor:
Meritxell López-Canet, Joan-Carles Fernàndez, Josep Bonjoch, Nativitat Valls, Juanlo Catena, D. Terricabras
Publikováno v:
Tetrahedron: Asymmetry. 8:3143-3151
A diastereoselective synthesis of (−)-2-ethyloctahydroindol-6-one 12 starting from O- methyl- L -tyrosine 1 is described. The process first involves the synthesis of enantiopure (−)-1-(4-methoxyphenyl)-2-butylamine 8 , which, after Birch reductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e78983e0872bf221e399e40a211ac834
https://doi.org/10.1016/s0957-4166(97)00379-0
https://doi.org/10.1016/s0957-4166(97)00379-0
Publikováno v:
Tetrahedron: Asymmetry. 7:1899-1902
The first synthesis of 6-hydroxyoctahydroindole-2-carboxylic acid derivatives with a cis fusion in the azabicyclic nucleus is described. The synthesis involves a Birch reduction of O -methyl-L-tyrosine followed by an aminocyclization in acid medium t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1508938577ca3d9ac78754cd707b9b71
https://doi.org/10.1016/0957-4166(96)00225-x
https://doi.org/10.1016/0957-4166(96)00225-x
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c05e96a2934ad12b53443a131cff8ff3
https://doi.org/10.1002/chin.199647113
https://doi.org/10.1002/chin.199647113
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19a76dfa96b3eea8a81276f1ec8961bc
https://doi.org/10.1002/chin.200107174
https://doi.org/10.1002/chin.200107174
Publikováno v:
ChemInform. 33
The first total syntheses of aeruginosin 298-A (1) and aeruginosin 298-B (3) are described. The syntheses of the alternative putative structures 2 and 4 were also accomplished. The key common strategic element is the stereo-controlled synthesis of (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7279c42edd16197d19019c52a4b2cf3
https://doi.org/10.1002/chin.200210166
https://doi.org/10.1002/chin.200210166
Publikováno v:
ChemInform. 33
The first total synthesis of aquatic peptide microcin SF608 is described. Coupling of L-Hpla with the dipeptide L-Phe-L-Choi followed by coupling with agmatine and a deprotection step gave microcin SF608. In addition, the levorotatory character of L-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::add12e6158602a3a0e2d7d7d693b1134
https://doi.org/10.1002/chin.200245175
https://doi.org/10.1002/chin.200245175
Autor:
Stephan Bulat, Paul J. Edwards, Victor G. Matassa, Meinolf Thiemann, Oliver Hill, Claudia Rosenbaum, Meritxell López-Canet, Silvia Cerezo-Galvez, Sonja Nordhoff, Barbara Hoffmann-Enger, Christian Rummey, Achim Feurer
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(22)
For a series of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV ADME properties were improved by the incorporation of amide replacements. These efforts led to a novel series of potent and selective inhibitors of DPP-4 that exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6abb4d0aee80af1a24e0ac93b2016d
https://pubmed.ncbi.nlm.nih.gov/19833514
https://pubmed.ncbi.nlm.nih.gov/19833514
Autor:
Christian Rummey, Oliver Hill, Meinolf Thiemann, Stephan Bulat, Meritxell López-Canet, Sonja Nordhoff, Achim Feurer, Claudia Rosenbaum, Barbara Hoffmann-Enger, Victor G. Matassa, Paul J. Edwards, Silvia Cerezo-Galvez
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(16)
A series of highly potent and selective inhibitors of DPP-4 was optimized for ADMET properties. The effort resulted in the discovery of inhibitor 1g, that exhibits excellent efficacy in an oral glucose tolerance test and an attractive pharmacokinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bf27d088b23217795d0772f5062efa
https://pubmed.ncbi.nlm.nih.gov/19576767
https://pubmed.ncbi.nlm.nih.gov/19576767