Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Meritxell Huch"'
Autor:
Cristina Cacho-Navas, Carmen López-Pujante, Natalia Reglero-Real, Natalia Colás-Algora, Ana Cuervo, Jose Javier Conesa, Susana Barroso, Gema de Rivas, Sergio Ciordia, Alberto Paradela, Gianluca D'Agostino, Carlo Manzo, Jorge Feito, Germán Andrés, Francisca Molina-Jiménez, Pedro Majano, Isabel Correas, José-Maria Carazo, Sussan Nourshargh, Meritxell Huch, Jaime Millán
Publikováno v:
eLife, Vol 12 (2024)
Epithelial intercellular adhesion molecule (ICAM)-1 is apically polarized, interacts with, and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, which are n
Externí odkaz:
https://doaj.org/article/773515c15a6d4f4ebbf37f60f7041ad5
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102333- (2023)
Summary: Within the peri-portal region of the adult liver, portal fibroblasts exist in close proximity to epithelial ductal/cholangiocyte cells. However, the cellular interactions between them are poorly understood. Here, we provide two co-culture te
Externí odkaz:
https://doaj.org/article/b18dbcef0c454e0f98bc0ad952eeeecc
Autor:
Germán Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The E3 ubiquitin ligases RNF43/ZNRF3 are often mutated in cancer but their precise contribution to liver disease is unknown. Here, the authors show that RNF43/ZNRF3 alterations predispose to liver cancer by controlling the differentiation and lipid m
Externí odkaz:
https://doaj.org/article/b340f59562d343c38a3ffe78a2def2d3
Autor:
Lotta Hof, Till Moreth, Michael Koch, Tim Liebisch, Marina Kurtz, Julia Tarnick, Susanna M. Lissek, Monique M. A. Verstegen, Luc J. W. van der Laan, Meritxell Huch, Franziska Matthäus, Ernst H. K. Stelzer, Francesco Pampaloni
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-22 (2021)
Abstract Background Organoids are morphologically heterogeneous three-dimensional cell culture systems and serve as an ideal model for understanding the principles of collective cell behaviour in mammalian organs during development, homeostasis, rege
Externí odkaz:
https://doaj.org/article/985f7b88103b4a6eb9b07b3469ea7f06
Autor:
Angela L. Caipa Garcia, Jill E. Kucab, Halh Al-Serori, Rebekah S. S. Beck, Franziska Fischer, Matthias Hufnagel, Andrea Hartwig, Andrew Floeder, Silvia Balbo, Hayley Francies, Mathew Garnett, Meritxell Huch, Jarno Drost, Matthias Zilbauer, Volker M. Arlt, David H. Phillips
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 606 (2022)
Organoids are 3D cultures that to some extent reproduce the structure, composition and function of the mammalian tissues from which they derive, thereby creating in vitro systems with more in vivo-like characteristics than 2D monocultures. Here, the
Externí odkaz:
https://doaj.org/article/7d5e97cc34e2406ea181265f7f8c061b
Autor:
Elisa De Crignis, Tanvir Hossain, Shahla Romal, Fabrizia Carofiglio, Panagiotis Moulos, Mir Mubashir Khalid, Shringar Rao, Ameneh Bazrafshan, Monique MA Verstegen, Farzin Pourfarzad, Christina Koutsothanassis, Helmuth Gehart, Tsung Wai Kan, Robert-Jan Palstra, Charles Boucher, Jan NM IJzermans, Meritxell Huch, Sylvia F Boj, Robert Vries, Hans Clevers, Luc JW van der Laan, Pantelis Hatzis, Tokameh Mahmoudi
Publikováno v:
eLife, Vol 10 (2021)
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system. Here we propose the use of human liver organoids as a platform for
Externí odkaz:
https://doaj.org/article/14b4dd868a334facbdb13052dadd9b22
Autor:
Cindy J.M. Loomans, Nerys Williams Giuliani, Jeetindra Balak, Femke Ringnalda, Léon van Gurp, Meritxell Huch, Sylvia F. Boj, Toshiro Sato, Lennart Kester, Susana M. Chuva de Sousa Lopes, Matthias S. Roost, Susan Bonner-Weir, Marten A. Engelse, Ton J. Rabelink, Harry Heimberg, Robert G.J. Vries, Alexander van Oudenaarden, Françoise Carlotti, Hans Clevers, Eelco J.P. de Koning
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 712-724 (2018)
Summary: Generating an unlimited source of human insulin-producing cells is a prerequisite to advance β cell replacement therapy for diabetes. Here, we describe a 3D culture system that supports the expansion of adult human pancreatic tissue and the
Externí odkaz:
https://doaj.org/article/26dfd9d03dab480b970ce0861845e50f
Autor:
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Ingrid G.W.H. Vernooij, Ingrid M. Schrall, Monique E. van Wolferen, Farah Bannink, Camille Roesch, Lisa van Uden, Martijn R. Molenaar, J. Bernd Helms, Guy C.M. Grinwis, Monique M.A. Verstegen, Luc J.W. van der Laan, Meritxell Huch, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee
Publikováno v:
Stem Cell Reports, Vol 8, Iss 4, Pp 822-830 (2017)
Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure. Previous studies demonstrate the p
Externí odkaz:
https://doaj.org/article/1b75311bbf3843328b88a26d9590e37a
Autor:
Madeline A. Lancaster, Meritxell Huch
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
The past decade has seen an explosion in the field of in vitro disease modelling, in particular the development of organoids. These self-organizing tissues derived from stem cells provide a unique system to examine mechanisms ranging from organ devel
Externí odkaz:
https://doaj.org/article/74570215f6924f2f87fdfe07e91c8691
Autor:
Sathidpak Nantasanti, Bart Spee, Hedwig S. Kruitwagen, Chen Chen, Niels Geijsen, Loes A. Oosterhoff, Monique E. van Wolferen, Nicolas Pelaez, Hille Fieten, Richard W. Wubbolts, Guy C. Grinwis, Jefferson Chan, Meritxell Huch, Robert R.G. Vries, Hans Clevers, Alain de Bruin, Jan Rothuizen, Louis C. Penning, Baukje A. Schotanus
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 895-907 (2015)
The recent development of 3D-liver stem cell cultures (hepatic organoids) opens up new avenues for gene and/or stem cell therapy to treat liver disease. To test safety and efficacy, a relevant large animal model is essential but not yet established.
Externí odkaz:
https://doaj.org/article/1abf448ce02c4f37b5e21cdc6b0ded40