Zobrazeno 1 - 10 of 44 pro vyhledávání: '"Merit E, Cudkowicz"'
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Akademický článek
A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS
Autor: Jonathan S. Katz, Jeffrey D. Rothstein, Merit E. Cudkowicz, Angela Genge, Björn Oskarsson, Avis B. Hains, Chen Chen, Joshua Galanter, Braydon L. Burgess, William Cho, Geoffrey A. Kerchner, Felix L. Yeh, Arundhati Sengupta Ghosh, Sravanthi Cheeti, Logan Brooks, Lee Honigberg, Jessica A. Couch, Michael E. Rothenberg, Flavia Brunstein, Khema R. Sharma, Leonard van denBerg, James D. Berry, Jonathan D. Glass
Publikováno v: Annals of Clinical and Translational Neurology, Vol 9, Iss 1, Pp 50-66 (2022)
Abstract Objective Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (AL
Externí odkaz: https://doaj.org/article/fe4980573fc74660b0489437b3effc6d
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2
Akademický článek
Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform
Autor: Frank W. Pun, Bonnie Hei Man Liu, Xi Long, Hoi Wing Leung, Geoffrey Ho Duen Leung, Quinlan T. Mewborne, Junli Gao, Anastasia Shneyderman, Ivan V. Ozerov, Ju Wang, Feng Ren, Alexander Aliper, Evelyne Bischof, Evgeny Izumchenko, Xiaoming Guan, Ke Zhang, Bai Lu, Jeffrey D. Rothstein, Merit E. Cudkowicz, Alex Zhavoronkov
Publikováno v: Frontiers in Aging Neuroscience, Vol 14 (2022)
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with ill-defined pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we applied PandaOmics, an AI-driven target discovery platform, to analyze th
Externí odkaz: https://doaj.org/article/d12999749a99465fb2c046587d7bb7ef
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5
Akademický článek
Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial
Autor: Suma Babu, Baileigh G. Hightower, James Chan, Nicole R. Zürcher, Pia Kivisäkk, Chieh-En J. Tseng, Danica L. Sanders, Ashley Robichaud, Haruhiko Banno, Armineuza Evora, Akshata Ashokkumar, Lindsay Pothier, Sabrina Paganoni, Sheena Chew, Joanna Dojillo, Kazuko Matsuda, Mark Gudesblatt, James D. Berry, Merit E. Cudkowicz, Jacob M Hooker, Nazem Atassi
Publikováno v: NeuroImage: Clinical, Vol 30, Iss , Pp 102672- (2021)
Ibudilast (MN-166) is an inhibitor of macrophage migration inhibitory factor (MIF) and phosphodiesterases 3,4,10 and 11 (Gibson et al., 2006; Cho et al., 2010). Ibudilast attenuates CNS microglial activation and secretion of pro-inflammatory cytokine
Externí odkaz: https://doaj.org/article/6307ae02502a42e6a2a3542ec44d074d
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6
Akademický článek
Recruitment & retention program for the NeuroNEXT SMA Biomarker Study: Super Babies for SMA!
Autor: Amy Bartlett, Stephen J. Kolb, Allison Kingsley, Kathryn J. Swoboda, Sandra P. Reyna, Ai Sakonju, Basil T. Darras, Richard Shell, Nancy Kuntz, Diana Castro, Susan T. Iannaccone, Julie Parsons, Anne M. Connolly, Claudia A. Chiriboga, Craig McDonald, W. Bryan Burnette, Klaus Werner, Mathula Thangarajh, Perry B. Shieh, Erika Finanger, Christopher S. Coffey, Jon W. Yankey, Merit E. Cudkowicz, Michelle M. McGovern, D. Elizabeth McNeil, W. David Arnold, John T. Kissel
Publikováno v: Contemporary Clinical Trials Communications, Vol 11, Iss , Pp 113-119 (2018)
Background/Aims: Recruitment and retention of research participants are challenging and critical components of successful clinical trials and natural history studies. Infants with spinal muscular atrophy (SMA) have been a particularly challenging pop
Externí odkaz: https://doaj.org/article/c20105f5211a4c60a677082f4b5666d9
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7
Akademický článek
Imaging of glia activation in people with primary lateral sclerosis
Autor: Sabrina Paganoni, Mohamad J. Alshikho, Nicole R. Zürcher, Paul Cernasov, Suma Babu, Marco L. Loggia, James Chan, Daniel B. Chonde, David Izquierdo Garcia, Ciprian Catana, Caterina Mainero, Bruce R. Rosen, Merit E. Cudkowicz, Jacob M. Hooker, Nazem Atassi
Publikováno v: NeuroImage: Clinical, Vol 17, Iss , Pp 347-353 (2018)
Background: Glia activation is thought to contribute to neuronal damage in several neurodegenerative diseases based on preclinical and human post-mortem studies, but its role in primary lateral sclerosis (PLS) is unknown. Objectives: To localize and
Externí odkaz: https://doaj.org/article/d94e9b8ad59c4b3aa96865694e1ff0d6
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8
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines
Autor: Emily G. Baxi, Terri Thompson, Jonathan Li, Julia A. Kaye, Ryan G. Lim, Jie Wu, Divya Ramamoorthy, Leandro Lima, Vineet Vaibhav, Andrea Matlock, Aaron Frank, Alyssa N. Coyne, Barry Landin, Loren Ornelas, Elizabeth Mosmiller, Sara Thrower, S. Michelle Farr, Lindsey Panther, Emilda Gomez, Erick Galvez, Daniel Perez, Imara Meepe, Susan Lei, Berhan Mandefro, Hannah Trost, Louis Pinedo, Maria G. Banuelos, Chunyan Liu, Ruby Moran, Veronica Garcia, Michael Workman, Richie Ho, Stacia Wyman, Jennifer Roggenbuck, Matthew B. Harms, Jennifer Stocksdale, Ricardo Miramontes, Keona Wang, Vidya Venkatraman, Ronald Holewenski, Niveda Sundararaman, Rakhi Pandey, Danica-Mae Manalo, Aneesh Donde, Nhan Huynh, Miriam Adam, Brook T. Wassie, Edward Vertudes, Naufa Amirani, Krishna Raja, Reuben Thomas, Lindsey Hayes, Alex Lenail, Aianna Cerezo, Sarah Luppino, Alanna Farrar, Lindsay Pothier, Carolyn Prina, Todd Morgan, Arish Jamil, Sarah Heintzman, Jennifer Jockel-Balsarotti, Elizabeth Karanja, Jesse Markway, Molly McCallum, Ben Joslin, Deniz Alibazoglu, Stephen Kolb, Senda Ajroud-Driss, Robert Baloh, Daragh Heitzman, Tim Miller, Jonathan D. Glass, Natasha Leanna Patel-Murray, Hong Yu, Ervin Sinani, Prasha Vigneswaran, Alexander V. Sherman, Omar Ahmad, Promit Roy, Jay C. Beavers, Steven Zeiler, John W. Krakauer, Carla Agurto, Guillermo Cecchi, Mary Bellard, Yogindra Raghav, Karen Sachs, Tobias Ehrenberger, Elizabeth Bruce, Merit E. Cudkowicz, Nicholas Maragakis, Raquel Norel, Jennifer E. Van Eyk, Steven Finkbeiner, James Berry, Dhruv Sareen, Leslie M. Thompson, Ernest Fraenkel, Clive N. Svendsen, Jeffrey D. Rothstein
Publikováno v: Nature Neuroscience. 25:226-237
Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and smartphone data from over 1,000 patients with ALS. This resource pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcf0bf833d3caf459c35b182e837fc5
https://doi.org/10.1038/s41593-021-01006-0
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9
Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development
Autor: Sabrina, Paganoni, James D, Berry, Melanie, Quintana, Eric, Macklin, Benjamin R, Saville, Michelle A, Detry, Marianne, Chase, Alexander V, Sherman, Hong, Yu, Kristin, Drake, Jinsy, Andrews, Jeremy, Shefner, Lori B, Chibnik, Matteo, Vestrucci, Merit E, Cudkowicz, Margherita, Torti
Publikováno v: Annals of Neurology. 91:165-175
Current therapeutic development in amyotrophic lateral sclerosis (ALS) relies on individual randomized clinical trials to test a specific investigational product in a single patient population. This approach has intrinsic limitations, including cost,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53991fcbeb0b07905e37fb08161b3a4e
https://doi.org/10.1002/ana.26285
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