Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Merissa Baxter"'
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Data from Targeting Subcellular Localization through the Polo-Box Domain: Non-ATP Competitive Inhibitors Recapitulate a PLK1 Phenotype
Autor: Michael D. Wyatt, Jianjun Wang, John S. Lazo, Paul Johnston, Doaa Boshra Farag, Zhengguan Yang, Merissa Baxter, Kara Estes, Campbell McInnes
The polo-box domain (PBD) has critical roles in the mitotic functions of polo-like kinase 1 (PLK1). The replacement with partial ligand alternative through computational enrichment (REPLACE) strategy to develop inhibitors of protein–protein interac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349c955cb675e9f7eb198ac9cb4aa9b5
https://doi.org/10.1158/1535-7163.c.6535941
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7
Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE
Autor: Merissa Baxter, Elmar Nurmemmedov, Diego Altomare, Jessy M. Stafford, Danda Chapagai, Campbell McInnes, Sandra Craig, Michael D. Wyatt
Publikováno v: Eur J Med Chem
Polo-like kinase 1 (PLK1) is a serine/threonine-protein kinase involved in cell cycle regulation and mitotic progression. Studies have shown that PLK1 is upregulated in many tumors and high levels are adversely related to a poor prognosis. Knocking d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969aa721b201d9bdb16662138b80e111
https://europepmc.org/articles/PMC9137042/
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8
Abstract 2572: A novel strategy for PLK1 kinase inhibition by allosterically targeting the Polo Box Domain
Autor: Danda Chapagai, Merissa Baxter, Sandra Craig, Guru Ramamoorthy, Jessy Stafford, Sikirzhytski Vitali, Elmar Nurmemmedov, Campbell McInnes, Michael D. Wyatt
Publikováno v: Cancer Research. 82:2572-2572
Polo Like Kinase 1 (PLK1) is only expressed in dividing cells and plays a critical role in several stages of mitosis. PLK1 is overexpressed in many tumor types. PLK1 inhibition selectively kills cancer cells because they are dependent on the mitotic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::819a92c8aff3c9b63b0ee0197c56f064
https://doi.org/10.1158/1538-7445.am2022-2572
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9
Peptidomimetic Polo-Box targeted inhibitors that engage PLK1 in tumor cells and are selective against the PLK3 tumor suppressor
Autor: Michael D. Wyatt, Sandra Craig, Merissa Baxter, Jessy Varghese, Danda Chapagai, Campbell McInnes, Cecilia Hurtado, Elmar Nurmemmedov
Publikováno v: ChemMedChem
The polo-box domain (PBD) of PLK1 determines mitotic substrate recognition and subcellular localization. Compounds that target PLK1 selectively are required due to the tumor-suppressor roles of PLK3. A structure-activity analysis of the PBD phosphope
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645740c0fb010eb5bbde88b4927e93d9
https://europepmc.org/articles/PMC7703809/
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10
Abstract 1241: Converting high affinity peptides to non-peptidic inhibitors via REPLACE: Novel and new strategies in targeting PLK1 Polo Box Domain (PBD) for anti-cancer therapy
Autor: Michael D. Wyatt, Sandra Craig, Elmar Nurmemmedov, McInnes Campbell, Danda Chapagai, Merissa Baxter, Guru Ramamoorthy
Publikováno v: Cancer Research. 81:1241-1241
Polo Like Kinase 1 (PLK1) is only expressed in dividing cells and plays a critical role in several stages of mitosis. PLK1 is highly expressed in tumors of various origins while its expression is largely absent in normal tissues. PLK1 inhibition sele
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14e5be833e71e108181b7a18994d63b2
https://doi.org/10.1158/1538-7445.am2021-1241
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