Zobrazeno 1 - 10
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pro vyhledávání: '"Merimepodib"'
Akademický článek
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Publikováno v:
Molecular Immunology. 114:226-232
Foot and mouth disease virus (FMDV), a member of family Picornaviridae, belongs to the genus Aphthovirus, which causes foot and mouth disease (FMD), a highly transmissible disease that affects cloven-hoof animals. In spite of the fact that efficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8ce0149648e5f6950382cf6357bce9
https://doi.org/10.1016/j.molimm.2019.07.021
https://doi.org/10.1016/j.molimm.2019.07.021
Autor:
Slobodan Paessler, Cheng Huang, Jerry Zeldis, Natalya Bukreyeva, Emily K. Mantlo, Rachel A. Sattler
The ongoing COVID-19 pandemic continues to pose a major public health burden around the world. The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over one million people worldwide as of April, 2020, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded4181aaeaf40a7aea1b231f3a75cae
https://doi.org/10.1101/2020.04.07.028589
https://doi.org/10.1101/2020.04.07.028589
Autor:
Emily K. Mantlo, Rachel A. Sattler, Natalya Bukreyeva, John T. Manning, Timothy G. Wanninger, Cheng Huang, Jerome B. Zeldis, Slobodan Paessler
Publikováno v:
F1000Research. 9:361
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel coronavirus responsible for the ongoing COVID-19 pandemic, which has resulted in over 2.5 million confirmed cases and 170,000 deaths worldwide as of late April 2020. The pandem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67678671e6521df09961059371889ea2
https://doi.org/10.12688/f1000research.23639.1
https://doi.org/10.12688/f1000research.23639.1
Autor:
Xiao Tong, Ann D. Kwong, John T. Manning, Slobodan Paessler, Jeanon N. Smith, Takaaki Koma, Natalya Bukreyeva, Raj Kalkeri
Publikováno v:
Antiviral research. 149
Zika virus (ZIKV), a member of the Flaviviridae family, has recently been linked to abnormal pregnancies, fetal death, microcephaly, and Guillain-Barre syndrome in humans. Merimepodib (MMPD, VX-497), a potent inhibitor of inosine-5′-monophosphate d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18967c598d82d6ef18d81a85f526c52
https://pubmed.ncbi.nlm.nih.gov/29126899
https://pubmed.ncbi.nlm.nih.gov/29126899
Akademický článek
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Development and Manufacture of the Inosine Monophosphate Dehydrogenase Inhibitor Merimepodib, VX-497
Autor:
Ansell Graham, Todd A. Blythe, Benjamin J. Littler, Minzhang Chen, John R. Snoonian, Looker Adam, Bobbianna J. Neubert, Phil Nyce, Jones Andrew D
Publikováno v:
Organic Process Research & Development. 12:666-673
A process for the manufacture of merimepodib (VX-497), an inosine monophosphate dehydrogenase (IMPDH) inhibitor, has been developed and efficiently scaled to produce clinical supply. The process comprises five steps, incorporating simple and robust c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec229f58119b23eb07b20edfe89f7cfe
https://doi.org/10.1021/op800060h
https://doi.org/10.1021/op800060h
Autor:
Robert Gish
Publikováno v:
Journal of Antimicrobial Chemotherapy. 57:8-13
Nucleos(t)ide analogues have proven useful in the treatment of viral infections. Ribavirin is a nucleoside, guanosine analogue, whose mechanisms of action include inhibition of inosine monophosphate dehydrogenase (IMPDH), which is the key step in de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa398162a796a1ef5171b2532ebc1af
https://doi.org/10.1093/jac/dki405
https://doi.org/10.1093/jac/dki405
Autor:
Teresa L. Wright, Stuart C. Gordon, John C. Pottage, Scott Moseley, Mitchell L. Shiffman, John Alam, John G. McHutchison, Lindsay McNair, Ramsey Cheung, Ene I. Ette
Publikováno v:
Antiviral Therapy. 10:635-643
Inhibition of inosine monophosphate dehydrogenase (IMPDH) is one of several proposed mechanisms of action for ribavirin (RBV), a critical component of the current treatment for chronic hepatitis C (CHC). This study was a double-blind, placebo-control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::423912413cc4f8436cb5b13e1c252f32
https://doi.org/10.1177/135965350501000503
https://doi.org/10.1177/135965350501000503
Akademický článek
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