Výsledky vyhledávání - "Merilyne Waldo"

Developmental and genetic influences on the p50 sensory gating phenotype

Autor: Merilyne Waldo, William Byerley, Robert Freedman, Marina Myles-Worsley, David L. Young, Hilary Coon

Publikováno v: Biological Psychiatry. 39:289-295

Evoked potentials to pairs of click stimuli were recorded from 127 subjects ranging in age from 10 to 39 years to examine the developmental course of auditory sensory gating. The ratio of the amplitude of the second response to that of the first prov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6375b456a9d18fa179377bf0622148c0
https://doi.org/10.1016/0006-3223(95)00134-4

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Nicotinic Receptor Function in Schizophrenia

Autor: Karen E. Stevens, Marina Myles-Worsley, Lawrence E. Adler, Charles R. Breese, Robert Freedman, Jay M. Griffith, Sherry Leonard, Hilary Coon, Christine L. Miller, William Byerley, Yvonne Rollins, Merilyne Waldo, Herbert T. Nagamoto, Catherine E. Adams, Paula C. Bickford

Publikováno v: Scopus-Elsevier
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Schizophrenia can be partially characterized by deficits in sensory processing. Biochemical, molecular, and genetic studies of one such endophenotype, the P50 auditory-evoked potential gating deficit, suggest that one of the neuronal nicotinic recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113232b4cbc5a0b16325f01eae6b3456
https://doi.org/10.1093/schbul/22.3.431

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Search for a schizophrenia susceptibility gene on chromosome 18

Autor: William Byerley, Frederick W. Reimherr, John Holik, Paul H. Wender, D. Hadley, Robert Freedman, Merilyne Waldo, Marina Myles-Worsley, Mark Hoff, N. Fang, Hilary Coon

Publikováno v: Psychiatric Genetics. 5:31-36

Nine multiplex schizophrenia families were genotyped with 15 microsatellite markers mapping to the short and long arm of chromosome 18. Assuming either autosomal dominant or recessive inheritance evidence of linkage was not found. In addition, the no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b92f230fdf89edf48d3ef4861cdc9c4
https://doi.org/10.1097/00041444-199521000-00005

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Linkage Analysis between Schizophrenia and Index Simple-Sequence Repeat Loci for Chromosome 21

Autor: Mark Hoff, Marina Myles-Worsley, Robert Freedman, John Holik, William Byerley, Hilary Coon, Merilyne Waldo

Publikováno v: Human Heredity. 45:49-52

Nine multiplex schizophrenia families were genotyped with seven highly polymorphic microsatellite loci used in the construction of an index map of chromosome 21. Assuming either autosomal dominant or recessive transmission, evidence of linkage was no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822a561b2a193abcb98f2d7cd1727355
https://doi.org/10.1159/000154254

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Schizophrenia and Nicotinic Receptors

Autor: Sherry Leonard, Greg M. Rose, Paula C. Bickford, Marina Myles-Worsley, Christine L. Miller, Jay M. Griffith, William Byerley, Lawrence E. Adler, C. Munro Cullum, Josette G. Harris, Robert Freedman, Herbert T. Nagamoto, Merilyne Waldo, Hilary Coon

Publikováno v: Harvard Review of Psychiatry. 2:179-192

Patients with schizophrenia often cannot respond to important features of their environment and filter out irrelevant stimuli. This dysfunction could be related to an underlying defect in inhibition--i.e., the brain's ability to alter its sensitivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a54d6f3e9da340da1fe3641f59a103
https://doi.org/10.3109/10673229409017136

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Genomic scan for genes predisposing to schizophrenia

Autor: Merilyne Waldo, Robert Freedman, Hilary Coon, John Holik, Mark Leppert, Frederick W. Reimherr, Mark Hoff, Paul H. Wender, M. Myles-Worsley, Steven Jensen, William Byerley

Publikováno v: American Journal of Medical Genetics. 54:59-71

We initiated a genome-wide search for genes predisposing to schizophrenia by ascertaining 9 families, each containing three to five cases of schizophrenia. The 9 pedigrees were initially genotyped with 329 polymorphic DNA loci distributed throughout

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9327d6edc57b6d1623e467622a202b
https://doi.org/10.1002/ajmg.1320540111

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Schizophrenia and glutamate receptor genes

Autor: Robert Freedman, Marina Myles-Worsley, Merilyne Waldo, Hilary Coon, C. Pariseau, P. Gregor, Mark Hoff, William Byerley, John Holik

Publikováno v: Psychiatric Genetics. 4:161-166

Nine multiplex schizophrenia families were genotyped with polymorphisms for the GLUR5 and NMDAR1 glutamate receptor subunit genes. Using the lod score technique, evidence of linkage was not found assuming either dominant or recessive transmission. Si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c192da7072ed38dc9b6bf4749428d32
https://doi.org/10.1097/00041444-199400430-00006

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Human Dopamine Transporter Gene Not Linked to Schizophrenia in Multigenerational Pedigrees

Autor: Marc G. Caron, William Byerley, Mark Hoff, Bruno Giros, Robert Freedman, John Holik, Hilary Coon, Merilyne Waldo

Publikováno v: Human Heredity. 43:319-322

A large body of data suggests that perturbations in brain dopaminergic transmission play a role in the pathogenesis of schizophrenia. Recently, the gene for the human dopamine transporter has been cloned and polymorphisms have been identified. Becaus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf738afb6faf8330d6346e7b3686e287
https://doi.org/10.1159/000154151

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