Výsledky vyhledávání - "Merilyne C. Waldo"

The genetics of sensory gating deficits in schizophrenia

Autor: Sherry Leonard, Karen E. Stevens, Merilyne C. Waldo, Ann Olincy, Robert Freedman, Lawrence E. Adler, R.G. Ross

Publikováno v: Current Psychiatry Reports. 5:155-161

Sensory gating abnormalities are an early clinical symptom of schizophrenia, and are characterized by a decrease in the brain's normal ability to inhibit the response to unimportant stimuli. Patients appear hypervigilant and have difficulty focusing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca421afd2ea136e10903d41d8b0af0f1
https://doi.org/10.1007/s11920-003-0032-2

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Input dysfunction, schizotypy, and genetic models of schizophrenia

Autor: Karen E. Stevens, Randal G. Ross, Merilyne C. Waldo, Ann Olincy, Sherry Leonard, Robert Freedman, Lawrence E. Adler

Publikováno v: Schizophrenia Research. 54:25-32

Peter Venables proposed that an input dysfunction, which causes the brain to lose its ability to control the flood of sensory information into its higher level processing areas, might be an important pathophysiological mechanism in schizophrenia. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a07494f11e6de996b7b463c3bb57c29
https://doi.org/10.1016/s0920-9964(01)00348-6

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Smoking and mental illness

Autor: Judith Gault, Judith Logel, D.E. Virnich, Bernadette Sullivan, Ann Olincy, Karen E. Stevens, Charles R. Breese, Ralph Berger, Robert Freedman, Randal G. Ross, Lawrence E. Adler, Carla Drebing, Michael J. Lee, K. Walton, R. Vianzon, Sherry Leonard, Khalid Benhammou, Merilyne C. Waldo

Publikováno v: Pharmacology Biochemistry and Behavior. 70:561-570

Patients with mental illness have a higher incidence of smoking than the general population and are the major consumers of tobacco products. This population includes subjects with schizophrenia, manic depression, depression, posttraumatic stress diso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0575fa7554fc2f9422008d01c931cdeb
https://doi.org/10.1016/s0091-3057(01)00677-3

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Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia

Autor: Judith Gault, Paula C. Bickford, Sherry Leonard, Clive E Adams, Randal G. Ross, Lawrence E. Adler, Ann Olincy, Josette G. Harris, Robert Freedman, Karen E. Stevens, Herbert T. Nagamoto, Merilyne C. Waldo

Publikováno v: American Journal of Medical Genetics. 97:58-64

SUMMARY Initial neurobiological and genetic evi-dence of inheritance of a physiologicalabnormality related to schizophreniahas been obtained, that implicates thea7 nicotinic receptor gene. Bilineal in-heritance may be associated with moresevere, earl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a23e051dce8d13fc89dcc47c198912e9
https://doi.org/10.1002/(sici)1096-8628(200021)97:1<58::aid-ajmg8>3.0.co

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Co-distribution of sensory gating and impaired niacin flush response in the parents of schizophrenics

Autor: Merilyne C. Waldo

Publikováno v: Schizophrenia Research. 40:49-53

Complex illnesses may result from the interaction or addition of multiple factors. We examined the familial co-distribution of two abnormalities common in schizophrenia: impaired auditory sensory gating and impaired flush response to niacin. In ten f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714d97a73b1ba7665f459341e325d484
https://doi.org/10.1016/s0920-9964(99)00031-6

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Heritability of Inhibitory Gating of the P50 Auditory-Evoked Potential in Monozygotic and Dizygotic Twins

Autor: Robert Freedman, Merilyne C. Waldo, James H. Rutledge, David A. Young

Publikováno v: Neuropsychobiology. 33:113-117

Most normal subjects suppress the P50 evoked response to repeated auditory stimulus when paired stimuli are presented, 500 ms apart. The ratio of the amplitude of the response to the second stimulus to that of the first forms a quantitative measure o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9975f243b6397b95113b74a714e480
https://doi.org/10.1159/000119260

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Auditory sensory gating and catecholamine metabolism in schizophrenic and normal subjects

Autor: Lawrence E. Adler, Greg A. Gerhardt, Neil Baker, Merilyne C. Waldo, Robert Freedman, Carla Drebing

Publikováno v: Psychiatry Research. 44:21-32

Diminished neuronal response to repeated sensory input is a sensory- gating phenomenon that has been found to be deficient in schizophrenic patients. For example, schizophrenic patients fail to decrease the amplitude of the P50 wave of the auditory e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a295e20bb746a46b2a7be318c40fa77
https://doi.org/10.1016/0165-1781(92)90066-c

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Varenicline and P50 Auditory Gating in Medicated Schizophrenic Patients: A Pilot Study

Autor: Lawrence E. Adler, Laurie Woodward, Merilyne C. Waldo

Most schizophrenic patients have a deficit in auditory sensory gating that appears to be mediated by the alpha-7 nicotinic receptor. This pilot study examines the effects of varenicline, an alpha-7 agonist, on the P50 auditory evoked potential in six

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744885a3f0de21aff7c8c27925529fd8
https://europepmc.org/articles/PMC2815213/

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