Výsledky vyhledávání - "Meriem El Ghachi"

Akademický článek

Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis

Autor: Meriem El Ghachi, Nicole Howe, Chia-Ying Huang, Vincent Olieric, Rangana Warshamanage, Thierry Touzé, Dietmar Weichert, Phillip J. Stansfeld, Meitian Wang, Fred Kerff, Martin Caffrey

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Bacterial cell wall components are assembled in a transmembrane cycle that involves the membrane integral pyrophosphorylase, BacA. Here the authors solve the crystal structure of BacA which shows an interdigitated inverted topology repeat that hints

Externí odkaz: https://doaj.org/article/987e6a420d7e43b5beb6875d278ef2d9

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Akademický článek

Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex

Autor: Carlos Contreras-Martel, Alexandre Martins, Chantal Ecobichon, Daniel Maragno Trindade, Pierre-Jean Matteï, Samia Hicham, Pierre Hardouin, Meriem El Ghachi, Ivo G. Boneca, Andréa Dessen

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Bacterial wall biosynthesis is a complex process that requires the coordination of multiple enzymes. Here, the authors structurally characterize the PBP2:MreC complex involved in peptidoglycan elongation and cross-linking, and demonstrate that its di

Externí odkaz: https://doaj.org/article/deb2c2d026dc4bb99411c94e9bd2ad5a

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Akademický článek

Membrane Topology and Biochemical Characterization of the Escherichia coli BacA Undecaprenyl-Pyrophosphate Phosphatase.

Autor: Guillaume Manat, Meriem El Ghachi, Rodolphe Auger, Karima Baouche, Samir Olatunji, Frédéric Kerff, Thierry Touzé, Dominique Mengin-Lecreulx, Ahmed Bouhss

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142870 (2015)

Several integral membrane proteins exhibiting undecaprenyl-pyrophosphate (C55-PP) phosphatase activity were previously identified in Escherichia coli that belonged to two distinct protein families: the BacA protein, which accounts for 75% of the C55-

Externí odkaz: https://doaj.org/article/1701164c9a5a47f2961811ce12dcb10e

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Akademický článek

Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid.

Autor: Marta Correia, Valérie Michel, Hugo Osório, Meriem El Ghachi, Mathilde Bonis, Ivo G Boneca, Hilde De Reuse, António A Matos, Pascal Lenormand, Raquel Seruca, Ceu Figueiredo, Jose Carlos Machado, Eliette Touati

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e60657 (2013)

H. pylori colonizes half of the world's population leading to gastritis, ulcers and gastric cancer. H. pylori strains resistant to antibiotics are increasing which raises the need for alternative therapeutic approaches. Docosahexaenoic acid (DHA) has

Externí odkaz: https://doaj.org/article/390620e051e24262a8e32b28a9a7426d

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Akademický článek

Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor 4.

Autor: Marcelo Hill, Ala-Eddine Deghmane, Mercedes Segovia, Maria Leticia Zarantonelli, Gaëlle Tilly, Philippe Blancou, Gaëlle Bériou, Régis Josien, Ignacio Anegon, Eva Hong, Corinne Ruckly, Aude Antignac, Meriem El Ghachi, Ivo Gomperts Boneca, Muhamed-Kheir Taha, Maria Cristina Cuturi

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e23995 (2011)

Neisseria meningitidis is a human pathogen responsible for life-threatening inflammatory diseases. Meningococcal penicillin-binding proteins (PBPs) and particularly PBP2 are involved in bacterial resistance to β-lactams. Here we describe a novel fun

Externí odkaz: https://doaj.org/article/61e725d987f74644a96064e4514e5ca7

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Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis

Autor: Martin Caffrey, Frédéric Kerff, Chia-Ying Huang, R. Warshamanage, Vincent Olieric, Nicole Howe, Meitian Wang, Meriem El Ghachi, Phillip J. Stansfeld, Dietmar Weichert, Thierry Touzé

Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, Nature Publishing Group, 2018, 9, pp.1078. ⟨10.1038/s41467-018-03477-5⟩
Nature Communications, 2018, 9, pp.1078. ⟨10.1038/s41467-018-03477-5⟩

As a protective envelope surrounding the bacterial cell, the peptidoglycan sacculus is a site of vulnerability and an antibiotic target. Peptidoglycan components, assembled in the cytoplasm, are shuttled across the membrane in a cycle that uses undec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0661b1b254c938fdf4b7c43f99f884e5
http://wrap.warwick.ac.uk/126682/1/WRAP-crystal-structure-undecaprenyl-pyrophosphate-biosynsthesis-Stansfeld-2018.pdf

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Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis

Autor: Alexandre Lambion, L. Vogeley, Dominique Mengin-Lecreulx, Sophie Roure, Juan-Carlos Rengifo-Gonzalez, Eric Sauvage, Sabine Peslier, Thierry Touzé, Paulette Charlier, Meriem El Ghachi, Frédéric Kerff, Maryline Foglino, Nicole Howe, Annick Guiseppi, Martin Caffrey, Guillaume Manat, François Delbrassine, Rodolphe Auger

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2017, 74 (12), pp.2319--2332. ⟨10.1007/s00018-017-2464-6⟩
Cellular and Molecular Life Sciences, Springer Verlag, 2017, 74 (12), pp.2319--2332. 〈10.1007/s00018-017-2464-6〉
Cellular and Molecular Life Sciences, 2017, 74 (12), pp.2319--2332. ⟨10.1007/s00018-017-2464-6⟩

International audience; Type 2 phosphatidic acid phosphatases (PAP2s) can be either soluble or integral membrane enzymes. In bacteria, integral membrane PAP2s play major roles in the metabolisms of glycerophospholipids, undecaprenyl-phosphate (C-55-P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36694a3235d12ba5550b68dc81ebdfb
https://hal.archives-ouvertes.fr/hal-01640041

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Penicillin Resistance Compromises Nod1-Dependent Proinflammatory Activity and Virulence Fitness of Neisseria meningitidis

Publikováno v: Cell Host and Microbe
Cell Host and Microbe, Elsevier, 2013, 13 (6), pp.735-745. ⟨10.1016/j.chom.2013.04.016⟩
Cell Host & Microbe
Cell Host and Microbe, 2013, 13 (6), pp.735-745. ⟨10.1016/j.chom.2013.04.016⟩

International audience; Neisseria meningitidis is a life-threatening human bacterial pathogen responsible for pneumonia, sepsis, and meningitis. Meningococcal strains with reduced susceptibility to penicillin G (Pen(I)) carry a mutated penicillin-bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12a449579d58418bf8d2ce171e9c5b2

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Catalytic mechanism of MraY and WecA, two paralogues of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily

Autor: Didier Blanot, Samir Olatunji, Meriem El Ghachi, Bayan Al-Dabbagh, Ahmed Bouhss, Muriel Crouvoisier, Dominique Mengin-Lecreulx

Publikováno v: Biochimie
Biochimie, Elsevier, 2016, 127, pp.249-57. ⟨10.1016/j.biochi.2016.06.005⟩
Biochimie, 2016, 127, pp.249-57. ⟨10.1016/j.biochi.2016.06.005⟩
Biochimie, Elsevier, 2016, 127, pp.249-57. 〈10.1016/j.biochi.2016.06.005〉

International audience; The MraY transferase catalyzes the first membrane step of bacterial cell wall peptidoglycan biosynthesis, namely the transfer of the N-acetylmuramoyl-pentapeptide moiety of the cytoplasmic precursor UDP-MurNAc-pentapeptide to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee6b838223edf983e44dc5ca9431d68
https://hal.archives-ouvertes.fr/hal-01441817

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