Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Meric Koksal"'
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 7, Pp 8071-8085 (2012)
A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a–g was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental anal
Externí odkaz:
https://doaj.org/article/15532b28aad04842a2358c63b1d7fbab
Publikováno v:
Turkish Journal of Chemistry
The reaction of 3,4-dichlorophenyl-1,3,4-oxadiazole-2( 3H )-thione with piperidine derivatives via Mannich reaction was used to generate eleven novel compounds in moderate to good yields. Synthesized molecules were characterized according to their st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f2d798a26d0e320be2fa1e4de5777e
https://doi.org/10.3906/kim-2008-44
https://doi.org/10.3906/kim-2008-44
Autor:
Wolfgang Sippl, Rengin Reis, Enise Ece Gurdal, Melda Özgürbüz, Ayca Dedeoglu-Erdogan, Turgay Celik, Meric Koksal, Hande Sipahi, Marwa Bader
Publikováno v:
Archiv der Pharmazie.
To obtain new anti-inflammatory agents, recent studies have aimed to replace the carboxylate functionality of nonsteroidal anti-inflammatory drugs with less acidic heterocyclic bioisosteres like 1,3,4-oxadiazole to protect the gastric mucosa from fre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2890a5decab9456e0ed10673e69118d4
https://doi.org/10.1002/ardp.202000469
https://doi.org/10.1002/ardp.202000469
Autor:
Enise Ece Gurdal, Hayrettin Ozan Gulcan, Tugce Ozyazici, Hande Sipahi, Tuba Ercetin, Meric Koksal, Duygu Orak
Publikováno v:
Archiv der PharmazieREFERENCES. 353(7)
A series of novel ibuprofen and salicylic acid-based 3,5-disubstituted-1,3,4-oxadiazole-2(3H)-thione derivatives was synthesized, and they were evaluated as potential anti-inflammatory agents. Following the structure identification studies employing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbfe0accc6680db0f5b47e7dcf8804c
https://pubmed.ncbi.nlm.nih.gov/32319141
https://pubmed.ncbi.nlm.nih.gov/32319141
Publikováno v:
European Journal of Chemistry. 8:1-7
The crystal and molecular structure of 1-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}-1 H -indole (I) has been determined by single-crystal X-ray diffraction. Molecular geometry of compound I in the ground state has been calculated using the density
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::097fbeacb0967e904fb721684617aad3
https://doi.org/10.5155/eurjchem.8.1.1-7.1512
https://doi.org/10.5155/eurjchem.8.1.1-7.1512
Autor:
Gulcin Tugcu, Meric Koksal
Publikováno v:
Molecular informaticsReferences. 38(8-9)
In this publication, QSAR models were developed to predict analgesic and anti-inflammatory activities of some 2-benzoxazolinone derivatives using multiple linear regression method. The models were validated internally and externally according to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f25337c3e21cf81b7fa144d440fd257
https://pubmed.ncbi.nlm.nih.gov/30478892
https://pubmed.ncbi.nlm.nih.gov/30478892
Autor:
Meric, Koksal, Irem, Ozkan-Dagliyan, Tugce, Ozyazici, Beril, Kadioglu, Hande, Sipahi, Ayhan, Bozkurt, Suleyman S, Bilge
Publikováno v:
Archiv der Pharmazie. 350(9)
Non-steroidal anti-inflammatory drugs (NSAIDs), which are widely used for the treatment of rheumatic arthritis, pain, and many different types of inflammatory disorders, cause serious gastrointestinal (GI) side effects. The free carboxylic acid group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::552336aa6c0f0e1aa9fe232b895d259d
https://pubmed.ncbi.nlm.nih.gov/28776720
https://pubmed.ncbi.nlm.nih.gov/28776720
Publikováno v:
Arzneimittelforschung. 58:510-514
Several 5-(3,4-dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiazoles were synthesized and characterized by elemental analyses, IR and nuclear magnetic resonance spectra. All compounds were evaluated for anti-inflammatory activity by determining their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b66d00985583edb0fbfc40fb4213d0
https://doi.org/10.1055/s-0031-1296550
https://doi.org/10.1055/s-0031-1296550
Publikováno v:
Chemical Biology & Drug Design. 78:869-875
To investigate the molecular features involved in sigma (σ) receptors binding, a series of compounds based on indole scaffolds were synthesized and their chemical structures were confirmed by (1) H-NMR, IR, and elemental analysis. Their affinity tow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e25794a0fc40aee672664a22908f791
https://doi.org/10.1111/j.1747-0285.2011.01215.x
https://doi.org/10.1111/j.1747-0285.2011.01215.x
Publikováno v:
Scopus-Elsevier
In this study, the synthesis of a novel series Mannich bases of 5-nitro-3-substituted piperazinomethyl-2-benzoxazolinones are described. The structures attributed to compounds 3a-3k were elucidated using IR, 1H-NMR spectroscopic techniques besides el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9bb90001af7347efe2e17fb30ded3e
https://doi.org/10.1007/bf02980214
https://doi.org/10.1007/bf02980214