Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Meric A. Ovacik"'
Autor:
Rajbharan Yadav, Siddharth Sukumaran, Tanja S. Zabka, Jinze Li, Amy Oldendorp, Gary Morrow, Arthur Reyes, Melissa Cheu, Jessica Li, Jeffrey J. Wallin, Siao Tsai, Laura Sun, Peiyin Wang, Diego Ellerman, Christoph Spiess, Andy Polson, Eric G. Stefanich, Amrita V. Kamath, Meric A. Ovacik
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 970 (2022)
The T cell-dependent bispecific (TDB) antibody, anti-CD79b/CD3, targets CD79b and CD3 cell-surface receptors expressed on B cells and T cells, respectively. Since the anti-CD79b arm of this TDB binds only to human CD79b, a surrogate TDB that binds to
Externí odkaz:
https://doaj.org/article/c576a9c94d774c0bbfd8b9f7d710cb3d
Autor:
Hao Cai, Satoko Kakiuchi-Kiyota, Robert Hendricks, Shelly Zhong, Luna Liu, Adeyemi O. Adedeji, Pamela Chan, Melissa M. Schutten, Amrita V. Kamath, Meric A. Ovacik
Publikováno v:
The AAPS journal. 24(6)
RO7297089, an anti-B-cell maturation antigen (BCMA)/CD16A bispecific tetravalent antibody, is being developed as a multiple myeloma (MM) therapeutic. This study characterized nonclinical pharmacokinetics (PK), pharmacodynamics (PD), soluble BCMA (sBC
Autor:
Thorsten Lehr, Christian Klein, Sylvia Herter, Tanja Fauti, Meric A. Ovacik, Miro J. Eigenmann, Marina Bacac, Tina Weinzierl, Arthur J Van De Vyver, Christian Pohl, Antje-Christine Walz
Publikováno v:
The AAPS journal. 24(1)
CD3-bispecific antibodies are a new class of immunotherapeutic drugs against cancer. The pharmacological activity of CD3-bispecifics is typically assessed through in vitro assays of cancer cell lines co-cultured with human peripheral blood mononuclea
Autor:
Amy C. Y. Lo, C. Andrew Boswell, Teemu T. Junttila, Thinh Pham, Genee Lee, Jian Payandeh, Danielle Mandikian, Maria Hristopoulos, James Ziai, Elaine Mai, Klara Totpal, Wei-Ching Liang, Yan Wu, Dionysos Slaga, Kathy Hötzel, Hao Cai, Ji Li, Meric A. Ovacik, Dorothee Nickles, Jennifer Johnston, Diego Ellerman, Daniel Bravo-Perez, Robyn Clark, Debra Dunlap
Publikováno v:
Molecular cancer therapeutics. 20(4)
Ovarian cancer is a diverse class of tumors with very few effective treatment options and suboptimal response rates in early clinical studies using immunotherapies. Here we describe LY6/PLAUR domain containing 1 (LYPD1) as a novel target for therapeu
Autor:
Meric A. Ovacik, Kedan Lin
Publikováno v:
Clinical and Translational Science. 11:540-552
The tutorial introduces the readers to the fundamentals of antibody pharmacokinetics (PK) in the context of drug development. Topics covered include an overview of antibody development, PK characteristics, and the application of antibody PK/pharmacod
Autor:
Jianhui Zhou, Jacob E. Corn, Zhilan Hu, Christoph Spiess, Yiyuan Yin, Teemu T. Junttila, Dionysos Slaga, Kedan Lin, Paul Carter, Michael Dillon, Luke McCarty, Meric A. Ovacik, Wendy Sandoval, Amy Shen, Guanghui Han, Diego Ellerman
Publikováno v:
mAbs
Bispecific IgG production in single host cells has been a much sought-after goal to support the clinical development of these complex molecules. Current routes to single cell production of bispecific IgG include engineering heavy chains for heterodim
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 354:448-458
Systems models of biological networks show promise for informing drug target selection/qualification, identifying lead compounds and factors regulating disease progression, rationalizing combinatorial regimens, and explaining sources of intersubject
Pharmacokinetic (PK) and pharmacodynamic (PD) models seek to describe the temporal pattern of drug exposures and their associated pharmacological effects produced at micro- and macro-scales of organization. Antibody-based drugs have been developed fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6b05eec571760f5fff8bf69ec8c0a0
https://europepmc.org/articles/PMC5240652/
https://europepmc.org/articles/PMC5240652/
Autor:
Vidya V. Iyer, Meric A. Ovacik, Marianthi G. Ierapetritou, Ioannis P. Androulakis, Charles M. Roth
Publikováno v:
Toxicology and Applied Pharmacology. 248:165-177
Conazoles are a class of azole fungicides used to prevent fungal growth in agriculture, for treatment of fungal infections, and are found to be tumorigenic in rats and/or mice. In this study, cultured primary rat hepatocytes were treated to two diffe
Publikováno v:
Current Bioinformatics. 3:142-148
Computational strategies, that integrate genomic-level information and metabolic flux data, have improved both prediction of metabolic fluxes and metabolic network identification. Due to the tight interplay between hierarchical (transcriptional) and