Glycan-specific IgM is critical for human immunity to Staphylococcus aureus

Autor: Astrid Hendriks, Priscilla F. Kerkman, Meri R.J. Varkila, Jelle L.G. Haitsma Mulier, Sara Ali, Thijs ten Doesschate, Thomas W. van der Vaart, Carla J.C. de Haas, Piet C. Aerts, Olaf L. Cremer, Marc J.M. Bonten, Victor Nizet, George Y. Liu, Jeroen D.C. Codée, Suzan H.M. Rooijakkers, Jos A.G. van Strijp, Nina M. van Sorge

Publikováno v: Cell Reports Medicine, Vol 5, Iss 9, Pp 101734- (2024)

Summary: Staphylococcus aureus is a major human pathogen, yet the immune factors that protect against infection remain elusive. High titers of opsonic IgG antibodies, achieved in preclinical animal immunization studies, have consistently failed to pr

Externí odkaz: https://doaj.org/article/87dd9b0611164e17939fce56791b0b44

Human Plasma IgG1 Repertoires are Simple, Unique, and Dynamic

Autor: Douwe Schulte, Marc J.M. Bonten, Albert J. R. Heck, Max Hoek, Olaf L. Cremer, Sem Tamara, Jean-François Greisch, Weiwei Peng, Joost Snijder, Maurits A. den Boer, Bastiaan de Graaf, Albert Bondt, Meri R.J. Varkila

Publikováno v: SSRN Electronic Journal.

The human body produces a vast variety of circulating immunoglobulins (Igs) to recognize and combat pathogens and other non-self molecular components. In human plasma the most abundant class of Igs is the immunoglobulin G subclass I (IgG1) 1. Through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8f78c4b97feebb59aa3c40fdabcc53e
https://doi.org/10.2139/ssrn.3749694

The association between HIV infection and pulmonary function in a rural African population

Autor: Alinda G. Vos, Hugo A. Tempelman, Kerstin Klipstein-Grobusch, Diederick E. Grobbee, Roos E. Barth, Roel A. Coutinho, Walter Devillé, Meri R.J. Varkila

Publikováno v: PLoS ONE, 14(1):e0210573. Public Library of Science
PLoS ONE, Vol 14, Iss 1, p e0210573 (2019)
PLoS ONE
PLoS ONE, 14(1). Public Library of Science

ObjectivesHIV infection has been associated with an impaired lung function in high-income countries, but the association between HIV infection and pulmonary function in Sub-Saharan Africa remains unclear. This study aims to investigate the relation b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59987221cf26bc9dc4565e304dbdf5ee
https://dare.uva.nl/personal/pure/en/publications/the-association-between-hiv-infection-and-pulmonary-function-in-a-rural-african-population(ecbf426f-c129-40a5-a9ef-2168b08dbe18).html