Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Meri Najdovska"'
Autor:
Brendan J. Jenkins, Tracy Putoczki, Cem Gabay, Masanobu Oshima, Matthias Ernst, Meri Najdovska, Hazel Tye, Ka Yee Fung, Hiroko Oshima, Adele Preaudet, Charlotte Girard, Thaleia Livis, Jesse Balic, Saleela M. Ruwanpura, Liang Yu, Alison F. Browning, Alison West, Paul Nguyen, Virginie Deswaerte
The content of this file containing Supplementary Figures (and a Supplementary Table) provides additional (and essential) data supporting our conclusions that the ASC inflammasome/caspase-1/IL-18 axis promotes gastric tumorigenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f645c44a30e642b4a7137f788bfaeca
https://doi.org/10.1158/0008-5472.22412141.v1
https://doi.org/10.1158/0008-5472.22412141.v1
Autor:
Brendan J. Jenkins, Tracy Putoczki, Cem Gabay, Masanobu Oshima, Matthias Ernst, Meri Najdovska, Hazel Tye, Ka Yee Fung, Hiroko Oshima, Adele Preaudet, Charlotte Girard, Thaleia Livis, Jesse Balic, Saleela M. Ruwanpura, Liang Yu, Alison F. Browning, Alison West, Paul Nguyen, Virginie Deswaerte
Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and autoimmune diseases, but their role in inflammation-associated tumorigenesis remains ill-defined. Here we reveal a protumorigenic role in gastric cancer for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::801933ca152887dfe221ae1ba60ea2a9
https://doi.org/10.1158/0008-5472.c.6508370.v1
https://doi.org/10.1158/0008-5472.c.6508370.v1
Autor:
Liang Yu, Adele Preaudet, Hazel Tye, Virginie Deswaerte, Masanobu Oshima, Hiroko Oshima, Jesse J. Balic, Alison C. West, Alison F. Browning, Matthias Ernst, Brendan J. Jenkins, Thaleia Livis, Saleela Ruwanpura, Paul M Nguyen, Meri Najdovska, Ka Yee Fung, Charlotte Girard, Tracy L Putoczki, Cem Gabay
Publikováno v:
Cancer Research, Vol. 78, No 5 (2018) pp. 1293-1307
Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and autoimmune diseases, but their role in inflammation-associated tumorigenesis remains ill-defined. Here we reveal a protumorigenic role in gastric cancer for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b177b2ddbe78247d8afdf955be72280d
https://pubmed.ncbi.nlm.nih.gov/29282220
https://pubmed.ncbi.nlm.nih.gov/29282220
Autor:
Meri Najdovska, Catherine Kennedy, Chia Huey Ooi, Patrick Tan, Cody C. Allison, Norman R. Hughes, Brendan J. Jenkins, Richard L. Ferrero, Prithi S. Bhathal, Anouk Dev, Gareth W. Jones, William Sievert, Louise McLeod, Simon Arnett Jones
Publikováno v:
The Journal of Pathology. 225:255-264
Chronic activation of the gastric mucosal adaptive immune response is a characteristic trait of gastric cancer. It has recently emerged that a new class of T helper (Th) cells, defined by their ability to produce interleukin (IL)-17A (Th17), is assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8601173a054f7fc6203d5da8ba31f8a
https://doi.org/10.1002/path.2933
https://doi.org/10.1002/path.2933
Autor:
Sara K. Lindén, C de Bolós, Raquel Mejías-Luque, Mar Iglesias, Meri Najdovska, Matthias Ernst, Brendan J. Jenkins, Marta Garrido, Hazel Tye
Publikováno v:
Oncogene. 29:1753-1762
Infection of gastric mucosa by Helicobacter pylori induces an inflammatory response with increased levels of proinflammatory cytokines. Among them, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 induce the activation of signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbba398c6bf0004395bcd2ca28f849b8
https://doi.org/10.1038/onc.2009.467
https://doi.org/10.1038/onc.2009.467
Autor:
Brendan J. Jenkins, L. Robb, Claire J. Greenhill, Dianne Grail, Matthias Ernst, Meri Najdovska, Therese Lundgren-May, Andrew W. Roberts
Publikováno v:
Blood. 109:2380-2388
We have previously demonstrated that STAT3 hyperactivation via the interleukin 6 (IL-6) cytokine family receptor gp130 in gp130 (Y757F/Y757F) mice leads to numerous hematopoietic and lymphoid pathologies, including neutrophilia, thrombocytosis, splen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877867617f61c14272f37e0cca17501e
https://doi.org/10.1182/blood-2006-08-040352
https://doi.org/10.1182/blood-2006-08-040352
Autor:
Nathan E. Hall, Meri Najdovska, T. T. I Stacey, Peter Lock, Hong S. He, Zhongzhen Nie, Ashley Stewart, Paul A. Randazzo
Publikováno v:
Journal of Cell Science. 117:6071-6084
ARAP3 is a GTPase activating protein (GAP) for Rho and Arf GTPases that is implicated in phosphoinositide 3-kinase (PI 3-kinase) signalling pathways controlling lamellipodia formation and actin stress fibre assembly. We have identified ARAP3 as a pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88ce99538ad368f2d9ea2230698889e
https://doi.org/10.1242/jcs.01526
https://doi.org/10.1242/jcs.01526
Autor:
Gareth W. Jones, Louise McLeod, Brendan J. Jenkins, Steven Bozinovski, Catherine Kennedy, Meri Najdovska
Publikováno v:
Jones, G W, McLeod, L, Kennedy, C L, Bozinovski, S, Najdovska, M & Jenkins, B J 2015, ' Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis ', Atherosclerosis, vol. 238, no. 2, pp. 321-328 . https://doi.org/10.1016/j.atherosclerosis.2014.12.037
Objective Interleukin (IL)-6 is a key modulator of the acute phase response (APR), and while both are implicated in atherosclerosis, the pathological role of specific IL-6 signalling cascades is ill-defined. Since IL-6 employs the cytokine receptor g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611d95a33c62814b411d2b1ee881d886
https://pubmed.ncbi.nlm.nih.gov/25545330
https://pubmed.ncbi.nlm.nih.gov/25545330
Autor:
Paul J. Hertzog, Daphne Dubach, Niamh E. Mangan, Matthew Hardy, Shamith A. Samarajiwa, Susie-Jane Braniff, Catherine M Owczarek, Meri Najdovska
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 192(9)
Circulating levels of a soluble type I IFNR are elevated in diseases, such as chronic inflammation, infections, and cancer, but whether it functions as an antagonist, agonist, or transporter is unknown. In this study, we elucidate the in vivo importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95523f631dfcbdfde75ad321d152462c
https://pubmed.ncbi.nlm.nih.gov/24696235
https://pubmed.ncbi.nlm.nih.gov/24696235
Autor:
Catherine Kennedy, Brendan J. Jenkins, Meri Najdovska, Tracy L Putoczki, Andrew G. Jarnicki, Louise McLeod, Hazel Tye, Matthias Ernst, Prithi S. Bhathal, Liang Yu
Publikováno v:
Oncogene. 33(19)
Signalling by the toll-like receptor (TLR) family of pathogen recognition receptors has emerged as a key molecular component in the pathogenesis of an increasing number of inflammatory-related cancers, among which gastric cancer rates as the second m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01031eef40c8d91cb3d5708ee289a348
https://pubmed.ncbi.nlm.nih.gov/23728346
https://pubmed.ncbi.nlm.nih.gov/23728346