Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho.

Autor: Abboud M; The Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. abboudmarana@gmail.com.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. abboudmarana@gmail.com., Merenbakh-Lamin K; The Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Volkov H; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Edmond J. Safra Center for Bioinformatics at Tel-Aviv University, Tel Aviv, Israel., Ben-Neriah S; The Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Ligumsky H; The Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Bronfeld S; The Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Keren-Khadmy N; The Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Giladi M; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Internal Medicine Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Shomron N; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Edmond J. Safra Center for Bioinformatics at Tel-Aviv University, Tel Aviv, Israel., Wolf I; The Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Rubinek T; The Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. tamarru@tlvmc.gov.il.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. tamarru@tlvmc.gov.il.

Publikováno v: Oncogene [Oncogene] 2024 Jan; Vol. 43 (5), pp. 354-362. Date of Electronic Publication: 2023 Dec 01.

Klotho rewires cellular metabolism of breast cancer cells through alteration of calcium shuttling and mitochondrial activity.

Autor: Shmulevich R; Institute of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Nissim TB; The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Wolf I; Institute of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Merenbakh-Lamin K; Institute of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Fishman D; The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Sekler I; The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. sekler@bgu.ac.il., Rubinek T; Institute of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. rubinekt@gmail.com.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. rubinekt@gmail.com.

Publikováno v: Oncogene [Oncogene] 2020 Jun; Vol. 39 (24), pp. 4636-4649. Date of Electronic Publication: 2020 May 12.

α-Klotho prevents diabetic retinopathy by reversing the senescence of macrophages.

Autor: Li, Qingbo^1,2,3 (AUTHOR), Wang, Peiyu^1,2,3 (AUTHOR), Gong, Yi^1,2,3 (AUTHOR), Xu, Manhong^1,2,3 (AUTHOR), Wang, Manqiao^1,2,3 (AUTHOR), Luan, Rong^1,2,3 (AUTHOR), Liu, Juping^1,2,3 (AUTHOR) tydljp@126.com, Li, Xiaorong^1,2,3 (AUTHOR) lixiaorong@tmu.edu.cn, Shao, Yan^1,2,3,4 (AUTHOR) sytmueh@163.com

Publikováno v: Cell Communication & Signaling. 9/26/2024, Vol. 22 Issue 1, p1-19. 19p.

R269C variant of ESR1: high prevalence and differential function in a subset of pancreatic cancers.

Autor: Boldes T; Institute of Oncology, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel., Merenbakh-Lamin K; Institute of Oncology, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel., Journo S; Institute of Oncology, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel., Shachar E; Institute of Oncology, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel., Lipson D; Foundation Medicine, Inc., Cambridge, MA, 02141, USA., Yeheskel A; The Bioinformatics Unit, George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel., Pasmanik-Chor M; The Bioinformatics Unit, George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel., Rubinek T; Institute of Oncology, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel., Wolf I; Institute of Oncology, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel. idow@tlvmc.gov.il.; Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel. idow@tlvmc.gov.il.

Publikováno v: BMC cancer [BMC Cancer] 2020 Jun 08; Vol. 20 (1), pp. 531. Date of Electronic Publication: 2020 Jun 08.

Promising reduction of de novo resistance to endocrine therapies in breast cancer by small molecules from natural origin: A structural approach.

Autor: Etti, Imaobong C.¹ imaobongetti@uniuyo.edu.ng, Kadir, Arifah A.², Uweh, Esther J.¹, Okuku, Cecilia³, Abdullah, Rasedee⁴

Publikováno v: Tropical Journal of Pharmaceutical Research. Jun2024, Vol. 23 Issue 6, p923-932. 10p.