Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Merel Derksen"'
Autor:
Merel Derksen, Vicky Mertens, Eline A. Visser, Janine Arts, Wilma Vree Egberts, Ger J. M. Pruijn
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 305-312 (2022)
RNase MRP is a ribonucleoprotein complex involved in the endoribonucleolytic cleavage of different RNAs. Mutations in the RNA component of the RNP are the cause of cartilage hair hypoplasia. Patients with cartilage hair hypoplasia are characterized b
Externí odkaz:
https://doaj.org/article/1ef8102a5f35469ebbed264ceedfbd6a
Publikováno v:
Bio-Protocol, Vol 13, Iss 4 (2023)
Interactions between RNA-binding proteins and RNA molecules are at the center of multiple biological processes. Therefore, accurate characterization of the composition of ribonucleoprotein complexes (RNPs) is crucial. Ribonuclease (RNase) for mitocho
Externí odkaz:
https://doaj.org/article/e2c09eb80764439bbf60996208e7e9f0
Publikováno v:
Biomolecules, Vol 5, Iss 4, Pp 3029-3050 (2015)
The RNA cleavage activity of RNase P can be employed to decrease the levels of specific RNAs and to study their function or even to eradicate pathogens. Two different technologies have been developed to use RNase P as a tool for RNA knockdown. In one
Externí odkaz:
https://doaj.org/article/43e44b12f27547d08cf2fabc5ed45fea
Autor:
Scott A Jelinsky, Merel Derksen, Eric Bauman, Carla S Verissimo, Wies T M van Dooremalen, Jamie Lee Roos, Celia Higuera Barón, Celia Caballero-Franco, Bryce G Johnson, Michelle G Rooks, Johanna Pott, Bas Oldenburg, Robert G J Vries, Sylvia F Boj, Marion T Kasaian, Farzin Pourfarzad, Charles V Rosadini
Publikováno v:
Inflammatory bowel diseases.
Background Patient-derived organoid (PDO) models offer potential to transform drug discovery for inflammatory bowel disease (IBD) but are limited by inconsistencies with differentiation and functional characterization. We profiled molecular and cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f32b4dc5502df57f0facfdee5d71ce9
https://pubmed.ncbi.nlm.nih.gov/36356046
https://pubmed.ncbi.nlm.nih.gov/36356046
Autor:
Stephanie Kourula, Merel Derksen, Ferran Jardi, Sophie Jonkers, Marjolein van Heerden, Peter Verboven, Veronique Theuns, Stijn Van Asten, Tinne Huybrechts, Annett Kunze, Ewa Frazer-Mendelewska, Ka Wai Lai, René Overmeer, Jamie Lee Roos, Robert G.J. Vries, Sylvia F. Boj, Mario Monshouwer, Farzin Pourfarzad, Jan Snoeys
Publikováno v:
European Journal of Pharmaceutical Sciences. :106481
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff41ba60f7d0e6a9dd68fb5df1bd0f7
https://doi.org/10.1016/j.ejps.2023.106481
https://doi.org/10.1016/j.ejps.2023.106481
Autor:
Lars-Eric Fielmich, Annemarie Buijs, Daniele Mori, Bas Viergever, Nihed Draoui, Anna Schepers, Mariana M. Costa e Silva, Mathijs Scholtus, Tokameh Mahmoudi, Tahlita Zuiverloon, Merel Derksen, Paul Gavine, Sylvia F. Boj, Richard Meijer, Onno Kranenburg, Janine Arts, Robert Vries
Publikováno v:
Cancer Research. 83:189-189
Conventional models for preclinical drug screening offer poor predictive value for patient response, causing high attrition rates of new agents in the clinic. HUB’s proprietary Patient-Derived Organoid (PDO) Technology enables long-term expansion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd5683fc0e56775cb6a8a0358fa38a9b
https://doi.org/10.1158/1538-7445.am2023-189
https://doi.org/10.1158/1538-7445.am2023-189
Publikováno v:
Molecular Neurobiology, 1-8
STARTPAGE=1;ENDPAGE=8;ISSN=0893-7648;TITLE=Molecular Neurobiology
Molecular Neurobiology, pp. 1-8
Molecular Neurobiology
STARTPAGE=1;ENDPAGE=8;ISSN=0893-7648;TITLE=Molecular Neurobiology
Molecular Neurobiology, pp. 1-8
Molecular Neurobiology
Concentrations of cell-free DNA (cfDNA) circulating in blood and its epigenetic variation, such as DNA methylation, may provide useful diagnostic or prognostic information. Long interspersed nuclear element-1 (LINE-1) constitutes approximately 20% of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97c173f36c9b0234531bf0f193a651c
https://doi.org/10.1007/s12035-017-0679-z
https://doi.org/10.1007/s12035-017-0679-z
Publikováno v:
Biomolecules, 5, 4, pp. 3029-3050
Biomolecules, 5, 3029-3050
Biomolecules, Vol 5, Iss 4, Pp 3029-3050 (2015)
Biomolecules
Biomolecules, 5, 3029-3050
Biomolecules, Vol 5, Iss 4, Pp 3029-3050 (2015)
Biomolecules
The RNA cleavage activity of RNase P can be employed to decrease the levels of specific RNAs and to study their function or even to eradicate pathogens. Two different technologies have been developed to use RNase P as a tool for RNA knockdown. In one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2290b7e81c19019d05f297aa17adb30
https://hdl.handle.net/2066/150327
https://hdl.handle.net/2066/150327
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1184
B cell epitope mapping is widely applied to determine antibody-binding sites. Several methods exist to map B cell epitopes and here we describe three methods that are characterized by the simultaneous analysis of multiple peptides. In the first appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33cbd86df8e3274a8f1845e505d4cb18
https://pubmed.ncbi.nlm.nih.gov/25048131
https://pubmed.ncbi.nlm.nih.gov/25048131
Publikováno v:
Methods in Molecular Biology ISBN: 9781493911141
B cell epitope mapping is widely applied to determine antibody-binding sites. Several methods exist to map B cell epitopes and here we describe three methods that are characterized by the simultaneous analysis of multiple peptides. In the first appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6a7af9c4099c77269d206bebfaf0f5f
https://doi.org/10.1007/978-1-4939-1115-8_16
https://doi.org/10.1007/978-1-4939-1115-8_16